Green synthesis, antibacterial activity and computational study of pyrazoline and pyrimidine derivatives from 3-(3,4-dimethoxy-phenyl-1-(2,5-dimethyl-thiophen-3-yl)-propenone

Single X-ray crystal and spectroscopic investigation of novel biologically active donor–acceptor chalcones as specific application for opto-electronics and photonics

“…Chalcones are the condensation product of acetophenone with aromatic aldehydes in the presence of strong base [2]. They exhibit a wide range spectrum of biological activities such as anti-bacterial [3], anti-oxidant [4], anti-inflammatory [5], anti-cancer [6] and antiviral [7]. Cyclization of chalcones gives the various heterocyclic compounds such as pyrazole, pyrimidine and pyridine by a nucleophilic addition reaction which enhanced the biological activities [8][9][10][11].…”

Microwave Assisted Synthesis of Some Substituted 2-Pyrazoline - A Green Approach.

“…The usage of microwave energy to accelerate the organic reactions is of increasing interest and offers several advantages over conventional heating techniques. 1 Synthesis of the molecules which normally requires a long time can be achieved conveniently and rapidly in microwave oven. Solvent free condition is especially suitable for microwave activation.…”

“…Pyrazolines are nitrogen containing 5-membered heterocyclic compound. It has only one endo-cyclic double bond and is basic in nature 1 . The pyrazoline function is quite stable and has inspired chemists to utilize this stable fragment in bioactive moieties to synthesize new compounds possessing biological activities.…”

Synthesis and characterization of new 3,5-disubstituted-4,5-dihydro-1H-pyrazole and their carbothioamide derivatives

“…They have been reported to posses activities such as; EGFR-TK inhibitors [24], anticancer [24][25][26][27], MAO-B inhibitors [28,29], antimicrobial [30][31][32], anti-inflammatory [33], and antidepressant [34][35][36][37], along with other biological activities [38,39].…”