Green Synthesis Design, Spectroscopic Characterizations, and Biological Activities of Novel Pyrrole Derivatives: An Application to Evaluate Their Toxic Effect on Cotton Aphids

Abstract

Green synthesis design and spectroscopic characterizations of novel pyrrole derivatives (1–6) with insecticidal bioefficacy have been achieved. The toxic effect using a leaf dip bioassay method was used to assess the insecticidal bioefficacy of six ecofriendly‐synthesized pyrrole derivatives. The results demonstrated the significant insecticide effect of the proposed compounds against cotton aphids, after 24 hours of application. All these compounds (1–6) showed promising results against cotton aphids especially compound 4 with an LC50 of 0.04 ppm which had a higher activity compared to a commercial reference of Chlorfenapyr deadly agent used for cotton aphids. The biological activity profile of these compounds, using Trolox equivalent antioxidant capacity (TEAC) assay, antimicrobial activities against four gram‐positive bacteria, and antifungal activities against a yeast‐like fungus, in comparison with well‐known antimicrobial and antifungal referenced standards were evaluated and confirmed. The results revealed that some of these compounds showed antibacterial activities against bacterial species known to plant pathogenic. Additional investigation of the newly obtained derivatives was performed and discussed in this research work through computational tools to give better insights into the possible protein targets of these new analogues.

Design, green synthesis, and quorum sensing quenching potential of novel 2-oxo-pyridines containing a thiophene/furan scaffold and targeting a LasR gene on P. aeruginosa

“…Broth microdilution is one of the most basic antimicrobial susceptibility testing methods. As illustrated by Clinical and Laboratory Standards Institute Guidelines, 75,76 two-fold dilutions of the antimicrobial agent were prepared (1000, 500, 250, 125, 62.5, 31.25, 15.6, 7.8, 3.9, 1.9, 0.9 μg mL −1 ) in a liquid growth medium. A volume of 100 μL of Muller–Hinton broth media for bacteria or tryptic soy broth for fungi was dispensed in 96-well microtitration plate.…”

Anticancer Activities of Tetrasubstituted Imidazole‐Pyrimidine‐Sulfonamide Hybrids as Inhibitors of EGFR Mutants

“…The co‐crystallized ligand was considered the centre of the docking site. The generated docking poses were ranked according to their docking scores, and the best energy pose was selected [56,57] …”

“…The generated docking poses were ranked according to their docking scores, and the best energy pose was selected. [56,57] Data availability. The data that support the results of this study are available in the Supporting Information.…”

Functionalized Pyridines: Synthesis and Toxicity Evaluation of Potential Insecticidal Agents against Aphis craccivora

“…The toxicological activities of target pyridine analogues were calculated using the leaf dipping technique under the same reported laboratory conditions. − Thus, we prepared five concentrations of all compounds dissolved in drops of dimethylformamide with the use of 0.1% Tween-80 as a surfactant. An identical size of 30 adults and also 30 nymphs of cowpea aphid insects were dipped for 10 s in each concentration of each compound “repeated three times”.…”