Green synthesis, formulation and biological evaluation of a novel ZnO nanocarrier loaded with paclitaxel as drug delivery system on MCF-7 cell line

Akbarian, Maedeh; Mahjoub, S.; Elahi, Seyed Mohammad; Zabihi, Ebrahim; Tashakkorian, Hamed

doi:10.1016/j.colsurfb.2019.110686

Cited by 63 publications

(28 citation statements)

References 32 publications

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“…The broadband in the range of 3400-3600 cm −1 was mainly due to the stretching vibration of the phenolic hydroxyl group (Darvishi et al 2019;Soto-Robles et al 2021;Lu et al 2019). The band at 2359 cm −1 was due to the C-H stretching vibrations of aromatic aldehyde (Akbarian et al 2020). A weak band at 1541 cm −1 corresponded to C=C stretching bonds of aromatic compounds in the extract (Vinayagam et al 2020b;Hu et al 2019).…”

Section: Ftir Studiesmentioning

confidence: 97%

Synthesis of photocatalytic zinc oxide nanoflowers using Peltophorum pterocarpum pod extract and their characterization

et al. 2021

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Zinc oxide nanoflowers (ZnONFs) were prepared by employing the pod extract of Peltophorum pterocarpum as a green resource and characterized by various methods. UV–vis spectrum displayed a peak at 361 nm which confirmed the formation of ZnO nanoparticles. The optical band gap was calculated as 3.43 eV. FE-SEM images exposed the flower-like morphology and EDX portrayed strong signals for Zn and O. XRD studies substantiated signature peaks for the wurtzite phase of ZnONFs and the lattice parameters matched well with the literature. Mesoporous nature was confirmed by BET analysis which yielded a high specific surface area of 19.61 m2/g. FTIR bands at 420.48 and 462.92 cm−1affirmed the Zn and O bonding vibrations. The photocatalytic potential of the ZnONFs was successfully examined for the removal of methylene blue dye under natural solar light. The experimental data were fitted to Langmuir–Hinshelwood’s first-order equation and the kinetic constant was calculated as 0.0114 min–1.

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Section: Ftir Studiesmentioning

confidence: 97%

Synthesis of photocatalytic zinc oxide nanoflowers using Peltophorum pterocarpum pod extract and their characterization

et al. 2021

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“…As a result, nanoparticles are commonly used in drug delivery systems, where they are loaded with drugs that reach their targets in appropriate quantities and then guide the drug release from the nanoparticles [ 51 ]. The effect of zinc oxide nanoparticles on drug delivery revealed that these nanoparticles aid in the rapid release of the drug at first and then transition to regulate the release over the treatment period [ 95 ]. The mechanisms underlying the enhanced cytotoxic potential of anticancer drug-loaded zinc oxide nanoparticles involve the pH-dependent release of targeted drug and zinc oxide nanoparticles in the cytoplasm once the drug-loaded zinc oxide nanoparticles enter through receptor-mediated endocytosis.…”

Section: Biomedical Applications Of Plant-mediated Zinc Oxide Nanoparticlesmentioning

confidence: 99%

“…The low toxicity and high anticancer therapy efficacy of DOX–zinc oxide nanoparticles were found to provide strong evidence for plant-mediated green synthesized zinc oxide nanoparticles as promising candidates in drug delivery systems. Akbarian et al [ 95 ] successfully loaded an important anticancer drug (Paclitaxel, PTX) on chitosan-coated zinc oxide nanoparticles, which were synthesized from the ethanolic leaf extract of Camellia sinensis and evaluated their biological activity as a drug delivery system on breast cancer cell lines (MCF-7). The PTX loaded on the chitosan-coated zinc oxide nanoparticles were found to show acytotoxic (anticancer) effect on cancerous MCF-7 cell lines and reduced the cytotoxic effect on normal fibroblast cell lines.…”

Section: Biomedical Applications Of Plant-mediated Zinc Oxide Nanoparticlesmentioning

confidence: 99%

Plant-Mediated Zinc Oxide Nanoparticles: Advances in the New Millennium towards Understanding Their Therapeutic Role in Biomedical Applications

et al. 2021

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Zinc oxide nanoparticles have become one of the most popular metal oxide nanoparticles and recently emerged as a promising potential candidate in the fields of optical, electrical, food packaging, and biomedical applications due to their biocompatibility, low toxicity, and low cost. They have a role in cell apoptosis, as they trigger excessive reactive oxygen species (ROS) formation and release zinc ions (Zn2+) that induce cell death. The zinc oxide nanoparticles synthesized using the plant extracts appear to be simple, safer, sustainable, and more environmentally friendly compared to the physical and chemical routes. These biosynthesized nanoparticles possess strong biological activities and are in use for various biological applications in several industries. Initially, the present review discusses the synthesis and recent advances of zinc oxide nanoparticles from plant sources (such as leaves, stems, bark, roots, rhizomes, fruits, flowers, and seeds) and their biomedical applications (such as antimicrobial, antioxidant, antidiabetic, anticancer, anti-inflammatory, photocatalytic, wound healing, and drug delivery), followed by their mechanisms of action involved in detail. This review also covers the drug delivery application of plant-mediated zinc oxide nanoparticles, focusing on the drug-loading mechanism, stimuli-responsive controlled release, and therapeutic effect. Finally, the future direction of these synthesized zinc oxide nanoparticles’ research and applications are discussed.

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“…To avoid such problems, there is a necessity to explore cheap and eco-friendly methods for the synthesis of nanoparticles. Plant extracts are more efficient due to their accessibility and the possession of several metabolites in them, helping to reduce Zn 2+ to ZnONPs (Akbarian et al (2020)). Moreover, the plant extracts are enriched with wide ranges of phytocompounds like polyphenols and flavonoids, deemed to be bio-reducing agents with no negative effects on the environment (Shayegan Mehr et al 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Few recent reports on the synthesis of ZnONPs include the use of various plant extracts such as Azadirachta indica (Haque et al 2020), Ilex paraguariensis (Bandeira 2020), Camellia sinensis L (Akbarian et al 2020), Acacia caesia (Manjari et al 2019), Jatropha gossypifolia (Krishnan et al 2020), Lippia adoensis (Demissie et al 2020), Justicia spicigera (Soto-Robles 1225), and Averrhoa carambola (Chakraborty et al 2020). In addition, our research group also has published leaf extract-mediated ZnONPs using Calliandra haematocephala (Vinayagam et al 2019), Cynometra ramiflora (Varadavenkatesan et al 2019), and Peltophorum pterocarpum (Pai et al 2019a).…”

Section: Introductionmentioning

confidence: 99%

Characterization and photocatalytic activity of ZnO nanoflowers synthesized using Bridelia retusa leaf extract

et al. 2021

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In the current work, the leaf extract of Bridelia retusa was used for the first time to synthesize zinc oxide nanoparticles (ZnONPs). A zinc nanoparticle-specific 364-nm peak was discerned via UV–Vis studies with a typical bandgap energy of 3.41 eV. FE-SEM micrographs revealed flower-shaped structure of the ZnONPs. EDS analysis corroborated the presence of zinc and oxygen. XRD spectrum established the wurtzite structure, sized at 11.06 nm. The mesoporous texture (4.89 nm) of the nanoparticles was deduced from BET analysis, proving a higher specific surface area than commercial ZnONPs. FTIR spectroscopy resulted in absorption bands typical for ZnONPs. Within a span of 165 min, under solar irradiation, the ZnONPs facilitated the photocatalytic degradation of Rhodamine B dye upto 94.74%. Exhibiting pseudo-first-order kinetics, the process had a degradation constant of 0.0109 min−1. It was concluded that numerous factors led to the high degradation efficiency. High values of bandgap energy and specific surface area, along with the mesoporous and crystalline nature of the ZnONPs led to the observed effect. The ZnONPs were also stabilized by the phytochemicals in the B. retusa leaves. The study is thus able to successfully demonstrate the huge potential in the field of environmental nanoremediation. The viability of using ZnONPs as solar photocatalysts for treating dye-laden industrial wastewater was thus attested.

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Green synthesis, formulation and biological evaluation of a novel ZnO nanocarrier loaded with paclitaxel as drug delivery system on MCF-7 cell line

Cited by 63 publications

References 32 publications

Synthesis of photocatalytic zinc oxide nanoflowers using Peltophorum pterocarpum pod extract and their characterization

Synthesis of photocatalytic zinc oxide nanoflowers using Peltophorum pterocarpum pod extract and their characterization

Plant-Mediated Zinc Oxide Nanoparticles: Advances in the New Millennium towards Understanding Their Therapeutic Role in Biomedical Applications

Characterization and photocatalytic activity of ZnO nanoflowers synthesized using Bridelia retusa leaf extract

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