Green Synthesis of Anisotropic Gold Nanoparticles for Photothermal Therapy of Cancer

Fazal, Sajid; Jayasree, Aswathy; Sasidharan, Sisini; Koyakutty, Manzoor; Nair, Shantikumar V.; Menon, Deepthy

doi:10.1021/am500302t

Cited by 178 publications

(109 citation statements)

References 41 publications

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“…As shown in Figures and , the morphology of biosynthesized AuNPs was nearly spherical in shape with small size, which was obtained by TEM and SEM analysis. A similar observation was found that spherical size is smaller than other morphologies . Some large images of biosynthesized AuNPs with triangle, pentagon and hexagon shapes were also observed.…”

Section: Discussionmentioning

confidence: 99%

Biological applications of phytosynthesized gold nanoparticles using leaf extract of Dracocephalum kotschyi

Chahardoli

Karimi

Fattahi

et al. 2018

J Biomedical Materials Res

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In this work, biosynthesis potentials of Dracocephalum kotschyi leaf extract for the production of gold nanoparticle (AuNPs) were studied, and the biological (catalytic, antibacterial, antioxidant, and anticancer) activities of studied AuNPs were evaluated. Different analytical techniques including UV–visible spectroscopy, X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), energy dispersive X‐ray analysis, and transmission electron microscopy (TEM) were used for the characterization of AuNPs. Moreover, Different testing methods were used for evaluating biological activities of biosynthesized AuNPs. The formation of AuNPs was confirmed by color change and UV–visible spectroscopic analysis. Field emission (FE)‐SEM and TEM images were used to characterize phytosynthesized AuNPs which were predominantly spherical in shape with size in the range of 5–21 nm. These spherical NPs were found to be 39.79 ± 5 nm in size as determined by dynamic light scattering particle size analyzer. XRD pattern confirms the crystalline nature of the biosynthesized nanoparticles. The phytoconstituents involved in the reduction and stabilization of nanoparticles have been identified using FTIR spectra. The phytosynthesized AuNPs showed effective antioxidant, antibacterial and catalytic reduction activities. Furthermore, they have inhibited H1229 and MCF‐7 cancer cell lines proliferation in a dose‐dependent manner. These results have supported that D. kotschyi leaf extract was very efficient for the synthesis of AuNPs, and synthesized NPs showed enhanced biological activities which make them suitable for biomedical applications. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 621–630, 2019.

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Section: Discussionmentioning

confidence: 99%

Biological applications of phytosynthesized gold nanoparticles using leaf extract of Dracocephalum kotschyi

Chahardoli

Karimi

Fattahi

et al. 2018

J Biomedical Materials Res

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“…AuNPs synthesized by green chemistry route using cocoa extract have shown NIR absorbance. The cell death was induced through the photo-thermal ablation of epidermoid carcinoma cells by these AuNPs, facilitating their use as photo-thermal therapeutic agents (Fazal et al 2014).…”

Section: Protein Denaturationmentioning

confidence: 99%

Metallic Nanoparticles, Toxicity Issues and Applications in Medicine

Singla

Guliani

Kumari

et al. 2016

Nanoscale Materials in Targeted Drug Delivery, Theragnosis and Tissue Regeneration

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The metallic nanoparticles (NPs) and their synthetic biology are an active area fascinating both the academics as well as scientific research applications in the field of nanotechnology. These nanostructures are a versatile class of materials such as metal NPs, metal oxide NPs, magnetic NPs and quantum dots for biomedical sciences and engineering due to their huge potential. A handful number of methods are adopted for the synthesis of one or the other kind of metal NPs which includes physical and chemical approaches. Each of the chemical and physical synthesis procedures deals with some limitations such as cost ineffectiveness, use of hazardous chemicals, formation of toxic end products and involvement of high-energy processes. To overcome these drawbacks, an alternative approach of environmentally benign and inexpensive biological synthesis mediated by plants or microbes has been essentially adopted. The variations in size, shape and surface chemistry of NPs affect the properties of metal NPs to a greater extent which in turn have an influence on their biological behaviour. Few metal NPs offer unique optical properties while others possess paramagnetic behaviour and quantum size effect which make them suitable in bio-imaging diagnostic techniques. Some metallic NPs play a role in tissue engineering and other therapeutic applications due to their ease of surface modifications, large surface area to volume ratio, unique electrical and anti-microbial activities. Instead of multi-disciplinary applications of metallic NPs, there is a great concern regarding the toxicity issues associated with the use of these NPs which need to be sorted out by looking out certain ways for favourable architecture involving the synthesis methods and parameters for designing the non-toxic NPs for improving the quality of life.

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“…Though in the wet chemical methods yielding of nanoparticles is very large but because of cytotoxity of synthetic reagents used like sodium borohydrate,cetrymethyle ammonium bromide (CTAB) it may not bea suitable one for bio analyticalapplication [4].Green synthesis of nano particle has overcome these problems by reducing hazardous and toxic bi-products and become an alternate of syntheticchemicals techniques. Asin greentechnique comprises of different plant parts, biomass and microorganisms etc that is all natural components so very less possibility of formation of toxic bi-products [5]. Among all the bio techniques plant leaf extract is wieldy explored as it is simple, one step, cost effective and ecofriendly and more over phythochemicals present in leaf extract act both as stabilising as well as capping agent [6,7].…”

Section: Introductionmentioning

confidence: 99%