Green synthesis of bimetallic ZnO–CuO nanoparticles and their cytotoxicity properties

Abstract

In this study, a simple and green strategy was reported to prepare bimetallic nanoparticles (NPs) by the combination of zinc oxide (ZnO) and copper oxide (CuO) using Sambucus nigra L. extract. The physicochemical properties of these NPs such as crystal structure, size, and morphology were studied by X-ray diffraction (XRD), field emission gun scanning electron microscopy (FEG-SEM), and transmission electron microscopy (TEM). The results suggested that these NPs contained polygonal ZnO NPs with hexagonal phase and spherical CuO NPs with monoclinic phase. The anticancer activity of the prepared bimetallic NPs was evaluated against lung and human melanoma cell lines based on MTT assay. As a result, the bimetallic ZnO/CuO NPs exhibited high toxicity on melanoma cancer cells while their toxicity on lung cancer cells was low.

Cytotoxicity evaluation of environmentally friendly synthesis Copper/Zinc bimetallic nanoparticles on MCF-7 cancer cells

“…In the XRD spectrum, distinct and sharp peaks are observed in the range of 31.9, 34.5, 35.5, 36.3, 38.8, 47.7, 56.7, 63.01, 66.5 and 68.1 degrees. Peaks of 35.5, 38.8, 66.5 and 68.4 degrees correspond to (002), (111), (311) and (220) Plane of pure CuO nanoparticles, respectively (Cao et al 2021b ). This single-phase with monoclinic structure confirms copper oxide nanoparticles.…”

“…Nanotechnology is a novel technology that has spread rapidly due to its transformative, miraculous and incredible effects (Cao et al 2021a ; Chu et al 2021 ). Nanotechnology has wide applications in various fields from food (Ningthoujam et al 2022 ; Parimaladevi et al 2018 ), medicine (Chu et al 2022 ), medical diagnostics (Nazari-Vanani et al 2019 ) and biotechnology (Kannan et al 2021 ; Rabiee et al 2021 ) to electronics (Song et al 2015 ), computers (Zhao et al 2021 ), communications (Zhao, Khan 2021 ), transportation (Mathew et al 2019 ), energy (Dey et al 2022 ), environment (Kannan et al 2020 ; Liu et al 2022 ), materials (Cao et al 2021b ; Wang et al 2022 ), aerospace (Haynes and Asmatulu 2013 ), and national security (Zha 2021 ). Currently, the special properties of these nanomaterials such as magnetic properties, quantum size, optical and biological properties have been considered by scientists (Luo et al 2021 ; Wang et al 2022 ; Rahdar et al 2021a ; Rahdar et al 2021b ).…”

Acacia nilotica Pods’ Extract Assisted-Hydrothermal Synthesis and Characterization of ZnO-CuO Nanocomposites

“…Various methods are applied to prepare metal oxide nanoparticles and nanocomposites as simple precipitation [ 23 ], electrochemical method [ 24 ], mechanical milling [ 1 ], sol-gel method [ 2 , 25 ], biocombustion [ 26 ], co-precipitation [ 27 ], green synthesis [ 28 , 29 ], sonochemical synthesis [ 30 ] and hydrothermal method [ 31 , 32 ]. The hydrothermal method has many advantages as being simple, low-cost, and low-temperature.…”

“…Moreover, the vapor deposition technique was used to prepare CuO-ZnO and applied in optoelectronics [ 37 ]. ZnO-CuO has been prepared by green synthesis using Sambucus nigra L. extract [ 28 ].…”

Drug delivery and anticancer activity of biosynthesised mesoporous Fe2O3nanoparticles

“…cancer cells, normal cells are targeted and destroyed [11]. Therefore, research and development of new cancer treatment methods are needed [12][13][14]. New developments in science and technology have significant impact on human health [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] and life [30][31][32][33][34][35][36].…”