Green synthesis of bioactive polysaccharide-capped gold nanoparticles for lymph node CT imaging

Uthaman, Saji; Kim, Hyeon Sik; Revuri, Vishnu; Min, Jung‐Joon; Lee, Yong-Kyu; Huh, Kang Moo; Park, Inkyu

doi:10.1016/j.carbpol.2017.10.042

Cited by 47 publications

(24 citation statements)

References 33 publications

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“…The diffraction peaks of 38.1° relates to (111), 44.5° relates to (200), 64.7° relates to (220), and 77.8° relates to (311) facets of the face center cubic (FCC) crystal lattice; these agree with reported values for similar gold nanostructures [ 69 ]. The reported peak values also matched the planes and face-centered cubic structures of AuNPs prepared by other green syntheses methods [ 22 , 70 , 71 , 72 ].…”

Section: Resultssupporting

confidence: 78%

Synthesis of Gold Nanoparticles Using Leaf Extract of Ziziphus zizyphus and their Antimicrobial Activity

et al. 2018

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(1) Background: There is a growing need for the development of new methods for the synthesis of nanoparticles. The interest in such particles has raised concerns about the environmental safety of their production methods; (2) Objectives: The current methods of nanoparticle production are often expensive and employ chemicals that are potentially harmful to the environment, which calls for the development of “greener” protocols. Herein we describe the synthesis of gold nanoparticles (AuNPs) using plant extracts, which offers an alternative, efficient, inexpensive, and environmentally friendly method to produce well-defined geometries of nanoparticles; (3) Methods: The phytochemicals present in the aqueous leaf extract acted as an effective reducing agent. The generated AuNPs were characterized by Transmission electron microscopy (TEM), Scanning electron microscope (SEM), and Atomic Force microscopy (AFM), X-ray diffraction (XRD), UV-visible spectroscopy, energy dispersive X-ray (EDX), and thermogravimetric analyses (TGA); (4) Results and Conclusions: The prepared nanoparticles were found to be biocompatible and exhibited no antimicrobial or antifungal effect, deeming the particles safe for various applications in nanomedicine. TGA analysis revealed that biomolecules, which were present in the plant extract, capped the nanoparticles and acted as stabilizing agents.

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Section: Resultssupporting

confidence: 78%

Synthesis of Gold Nanoparticles Using Leaf Extract of Ziziphus zizyphus and their Antimicrobial Activity

et al. 2018

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“…The peak of diffraction observed at 77.8°, 64.7°, 44.5°and 38.1°r elated to the facets 311, 220, 200 and 111, respectively, of the face-centered cubic (FCC) crystal lattice, which are compatible with the recorded values of different gold nanostructures [27]. The recorded peak values have matched Au NP's FCC cubic structures as well as planes that were developed by other approaches of green synthesis [28][29][30][31]. Figure 4 shows the FTIR spectrum of the prepared AuNPs, which showed a strong absorption band at 3,400 cm −1 corresponding to O-H stretching vibrations of polyphenolic groups.…”

Section: Resultssupporting

confidence: 82%

A novel biofabrication of gold nanoparticles using Erythrina senegalensis leaf extract and their ameliorative effect on mycoplasmal pneumonia for treating lung infection in nursing care

Hong

2020

Green Processing and Synthesis

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This study showed the fabrication of gold nanoparticles (AuNPs) utilizing Erythrina senegalensis leaf extract as an effective, low-cost and eco-friendly approach. The bioconstituents existing in the E. senegalensis leaf extract are accountable for reducing and stabilization of NPs. The produced AuNPs were studied by using transmission electron microscopy, X-ray diffraction, UV-visible (UV-Vis) spectroscopy, Fourier transform infrared spectroscopy and energy-dispersive X-ray spectroscopy. In addition, this study also showed that the prepared AuNPs exhibited very good antipneumonial activity against mycoplasmal pneumonia in the investigational animals, indicating their potential for the development of new therapeutic drugs for the lung injury treatments in in the future.

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“…Green chemical synthesis of AuNPs involves the usage of water as a solvent along with biomolecules, such as amino acids, protein, carbohydrates, and phytochemicals as reducing and stabilizing agents. 2,3,5,19,20 Synthetic biocompatible polymers have also been used as stabilizing agents in the green synthesis of AuNPs. 21 Recently, multicarboxylate-PEG bifunctional copolymers, such as citrate-PEG (CPEG) copolymers were used as reducing and stabilizing agents, and the synthesized AuNPs were shown to be uniformly distributed on a CPEG copolymer matrix.…”

Section: Introductionmentioning

confidence: 99%

<p>Green synthesis of multifunctional PEG-carboxylate π back-bonded gold nanoconjugates for breast cancer treatment</p>

Gajendiran

Kim

et al. 2019

IJN

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BackgroundSurface functionalization of gold nanoparticles (AuNPs) has emerged as a promising field of research with enormous biomedical applications. The folate (FA)-attached polymer-gold nanoconjugates play vital role in targeting the cancer cells.MethodsAuNPs were synthesized by using di- or tri-carboxylate-polyethylene glycol (PEG) polymers, including citrate-PEG (CPEG), malate-PEG (MAP), and tartrate-PEG (TAP), as a reducing and stabilizing agent. After synthesis of polymer-AuNPs, the freely available hydroxyl and carboxylate groups of CPEG, MAP, and TAP were used to attach a cancer cell-targeting agent, FA, via a 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxy succinimide coupling reaction to obtain FA-CPEG-AuNP, FA-MAP-AuNP, and FA-TAP-AuNP nanocon-jugates, respectively. The 5-fluorouracil (5FU) was attached to π back-bonded carbonyl oxygens of the nanoconjugates, and the in vitro drug release profile was studied by high pressure liquid chromatography. Biocompatibility profiles of the FA-CPEG-AuNP, FA-MAP-AuNP, and FA-TAP-AuNP nanoconjugates were investigated using adult human dermal fibroblasts. Anti-breast cancer activity of 5FU-loaded nanoconjugates was investigated using MCF-7 breast cancer cells.ResultsX-ray photoelectron spectroscopy and Fourier-transform infrared spectroscopy analyses confirmed that AuNPs attached to CPEG, MAP, or TAP via the formation of π back bonding between AuNPs and the ester carbonyl group. The π back-bonded nanoconjugates exhibited sustained release of 5FU up to 27 days. FA-MAP-AuNPs exhibited an IC50 at 5 µg/mL, while FA-CPEG-AuNPs and FA-TAP-AuNPs showed the IC50 at 100 µg/mL toward MCF-7 cancer cells.ConclusionThe developed polymer π back-bonded multifunctional gold nanoconjugates could be used as a potential drug delivery system for targeting MCF-7 cancer cells.

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Green synthesis of bioactive polysaccharide-capped gold nanoparticles for lymph node CT imaging

Cited by 47 publications

References 33 publications

Synthesis of Gold Nanoparticles Using Leaf Extract of Ziziphus zizyphus and their Antimicrobial Activity

Synthesis of Gold Nanoparticles Using Leaf Extract of Ziziphus zizyphus and their Antimicrobial Activity

A novel biofabrication of gold nanoparticles using Erythrina senegalensis leaf extract and their ameliorative effect on mycoplasmal pneumonia for treating lung infection in nursing care

<p>Green synthesis of multifunctional PEG-carboxylate π back-bonded gold nanoconjugates for breast cancer treatment</p>

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Green synthesis of bioactive polysaccharide-capped gold nanoparticles for lymph node CT imaging

Cited by 47 publications

References 33 publications

Synthesis of Gold Nanoparticles Using Leaf Extract of Ziziphus zizyphus and their Antimicrobial Activity

Synthesis of Gold Nanoparticles Using Leaf Extract of Ziziphus zizyphus and their Antimicrobial Activity

A novel biofabrication of gold nanoparticles using Erythrina senegalensis leaf extract and their ameliorative effect on mycoplasmal pneumonia for treating lung infection in nursing care

<p>Green synthesis of multifunctional PEG-carboxylate &pi; back-bonded gold nanoconjugates for breast cancer treatment</p>

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<p>Green synthesis of multifunctional PEG-carboxylate π back-bonded gold nanoconjugates for breast cancer treatment</p>