Green synthesis of copper nanoparticles using Eclipta�prostrata leaves extract and their antioxidant and cytotoxic activities

Abstract

The present study outlines the development of a method to synthesize copper nanoparticles (CuNPs) by mixing copper acetate solution with leaf extract of Eclipta prostrata without using any surfactant or external energy. E. prostrata leaf extract function as an excellent reducing agent of copper ions, and the biosynthesized CuNPs are safer for the environment. The powder X-ray diffraction (XRD) pattern provided evidence for the formation of face-centered cubic structure ranging from 23 to 57 nm, with an average size of 31±1.2 nm. Fourier transform infrared spectroscopy (FTIR) was used to identify the biomolecules and capping reagents in the E. prostrata leaf extract that may be responsible for the reduction of copper ions and the stability of the bioreduced nanoparticles. The biosynthesized CuNPs displayed considerable antioxidant capacity. Similarly, in vitro anticancer studies demonstrated the cytotoxicity value of synthesized CuNPs against tested HepG2 cells. The findings of the present study suggested that biosynthesized CuNPs that utilize extracts of E. prostrata may be used for therapeutic application, and thus are a promising nanomaterial.

A system for rapid and inexpensive treatment of sewage using the weed Eclipta prostrata in SHEFROL® bioreactor

“…; Chung et al . ). It is called bhringraj in the Ayurvedic system of medicine, which translates to ‘king of hair’.…”

“…These curative properties, especially against cancer and HIV, have led to extensive studies on nanoparticles synthesized biomimetically using aqueous extracts of E. prostrata (Chung et al . ; Rajakumar et al . ; Rajakumar & Rahuman ; Rajasekar et al .…”

“…E. prostrata has been a traditional medicine in the Chinese, Indian and other eastern Asian countries (Prajapati et al 2003;Liu et al 2012;Abhang et al 2015;Chung et al 2017). It is called bhringraj in the Ayurvedic system of medicine, which translates to 'king of hair'.…”

“…In addition it has been shown to have anti-HIV, antivenom, antidiabatic and antihelmintic attributes (Pithayanukul et al 2004;Tewtrakul et al 2007;Jahan et al 2014;Nathiya & Gayathri 2016;Kousalya et al 2017), and can protect against nurotoxicity (Jaisin et al 2016), infertility (Hung et al 2016), hepatotoxicity (Himaja and Neelufar Shama, 2015), and gastrointestinal disorders (Neamsuvan & Ruangrit 2017). These curative properties, especially against cancer and HIV, have led to extensive studies on nanoparticles synthesized biomimetically using aqueous extracts of E. prostrata (Chung et al , 2017Rajakumar et al 2012Rajakumar et al , 2015Rajakumar et al , 2016Rajakumar & Rahuman 2011;Rajasekar et al 2016) and assessment of their curative activity. Another manner in which E. prostrata has also been utilized is as a biosorbant (Chandra & Yadav 2017).…”

Studies on Adsorption of Congo red (Acid Red 28) Azodye by Nano Copperoxide

“…It contains eight enzymes [14]. These chemicals salicylic acid and anthraquinones (aloin, emodin, aloetic acid, anthranol, cinnamic acid, anthracene) are responsible for the reduction of copper [15,27].…”