Green Synthesis of Curcumin Derivatives with Expected Biological Activities as Potential Antitumor, Radical Scavenging Agents and Their Applications Antibacterial Wound Dressings

Abstract

The active methylenic carbon in curcumin can act as nucleophillic centre for the electrophillic attack of the diazonium salts of different aromatic and hetero aromatic amines to give the corresponding (1E,6E)-4-(aryl)hydrazono)-1-(2-hydroxy-3-methoxyphenyl)-7-(3-hydroxy-4methoxyphenyl)hepta-1,6-ene-3,5-dionederivatives (3a-g). Seven compounds were examined in vitro for their cytotoxicity activities against RPE-1 and MCF-7 human cell lines using MTT assay. The antimicrobial activities of the selected prepared compounds against the tested microorganisms indicated that all the prepared compounds have potential activity against the different Green Synthesis … Abu-Bakr Sh. M et al.