Bioremediation, employing microorganisms to degrade or immobilize environmental contaminants, is a promising approach for mitigating agricultural pollution. Recent advancements have highlighted the potential of nanomaterials to enhance microbial remediation strategies in agroecosystems. This chapter synthesizes current knowledge on the synergistic application of nanomaterials and microbial intervention for bioremediation purposes in agricultural settings. We discuss the mechanisms underlying the enhanced bioremediation efficacy facilitated by nanomaterials, encompassing improved microbial activity, pollutant adsorption, and targeted delivery systems. Furthermore, we assess the environmental implications, challenges, and future prospects associated with this innovative approach. Understanding the interplay between nanomaterials and microbial communities is crucial for optimizing bioremediation strategies and fostering sustainable agricultural practices.