Green synthesis of gold nanoparticles using a
            <i>Cordyceps militaris</i>
            extract and their antiproliferative effect in liver cancer cells (HepG2)

Ji, Yujiang; Yang, Cao; Song, Yong Jung

doi:10.1080/21691401.2019.1629952

Cited by 38 publications

(13 citation statements)

References 33 publications

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“…As an example, AuNPs synthesized with Trichosanthes kirilowii caused cell cycle arrest in G 0 /G 1 phase and induced apoptosis via activating several apoptotic pathways, involving bid, bax/bcl2 and caspases in colon cancer cells [121]. Similar activities were observed on A549 cells and on HepG2 hepatocellular carcinoma cells treated with green synthesized AuNPs prepared by using Marsdenia tenacissima plant extract [122] and AuNPs synthesized with Cordyceps militaris mushroom extract [11], respectively. AuNPs obtained with Nerium oleander extract also decreased the viability of MCF-7 cells.…”

Section: Toxicity and Anticancer Activity Of Green Synthesized Aunps mentioning

confidence: 57%

Green Silver and Gold Nanoparticles: Biological Synthesis Approaches and Potentials for Biomedical Applications

et al. 2021

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The nanomaterial industry generates gigantic quantities of metal-based nanomaterials for various technological and biomedical applications; however, concomitantly, it places a massive burden on the environment by utilizing toxic chemicals for the production process and leaving hazardous waste materials behind. Moreover, the employed, often unpleasant chemicals can affect the biocompatibility of the generated particles and severely restrict their application possibilities. On these grounds, green synthetic approaches have emerged, offering eco-friendly, sustainable, nature-derived alternative production methods, thus attenuating the ecological footprint of the nanomaterial industry. In the last decade, a plethora of biological materials has been tested to probe their suitability for nanomaterial synthesis. Although most of these approaches were successful, a large body of evidence indicates that the green material or entity used for the production would substantially define the physical and chemical properties and as a consequence, the biological activities of the obtained nanomaterials. The present review provides a comprehensive collection of the most recent green methodologies, surveys the major nanoparticle characterization techniques and screens the effects triggered by the obtained nanomaterials in various living systems to give an impression on the biomedical potential of green synthesized silver and gold nanoparticles.

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Section: Toxicity and Anticancer Activity Of Green Synthesized Aunps mentioning

confidence: 57%

Green Silver and Gold Nanoparticles: Biological Synthesis Approaches and Potentials for Biomedical Applications

et al. 2021

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“…Activation of Bax, Bid, and caspases and inhibition of bcl-2 activation was suggested as possible mechanisms of apoptosis. ROS is generated, which significantly damages the membrane potential of mitochondria in HepG2 cancer cells [ 163 ].…”

Section: Green Synthesis Of Aunps For Cancer Theranosticsmentioning

confidence: 99%

Application of Green Gold Nanoparticles in Cancer Therapy and Diagnosis

et al. 2022

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Nanoparticles are currently used for cancer theranostics in the clinical field. Among nanoparticles, gold nanoparticles (AuNPs) attract much attention due to their usability and high performance in imaging techniques. The wide availability of biological precursors used in plant-based synthesized AuNPs allows for the development of large-scale production in a greener manner. Conventional cancer therapies, such as surgery and chemotherapy, have significant limitations and frequently fail to produce satisfying results. AuNPs have a prolonged circulation time, allow easy modification with ligands detected via cancer cell surface receptors, and increase uptake through receptor-mediated endocytosis. To exploit these unique features, studies have been carried out on the use of AuNPs as contrast agents for X-ray-based imaging techniques (i.e., computed tomography). As nanocarriers, AuNPs synthesized by nontoxic and biocompatible plants to deliver therapeutic biomolecules could be a significant stride forward in the effective treatment of various cancers. Fluorescent-plant-based markers, including AuNPs, fabricated using Medicago sativa, Olax Scandens, H. ambavilla, and H. lanceolatum, have been used in detecting cancers. Moreover, green synthesized AuNPs using various extracts have been applied for the treatment of different types of solid tumors. However, the cytotoxicity of AuNPs primarily depends on their size, surface reactivity, and surface area. In this review, the benefits of plant-based materials in cancer therapy are firstly explained. Then, considering the valuable position of AuNPs in medicine, the application of AuNPs in cancer therapy and detection is highlighted with an emphasis on limitations faced by the application of such NPs in drug delivery platforms.

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“…The preparation of gold nanoparticles by a green route method using Cordyceps militaris extract have reported [49]. The formed gold nanoparticles have been assessed for their antiproliferative study against liver cancer cells (HepG2).…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

Biogenic Metal and Metal Oxides Nanoparticles as Anticancer Agent: A Review

Rani

Saini

2022

IOP Conf. Ser.: Mater. Sci. Eng.

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Herein this review we have summarized a number of cytotoxic studies which have been done using various biosynthesized metal nanoparticles (MNPs) and metal oxide nanoparticles (MONPs) on different cancer cell lines. Plants can serve as a good candidate to provide natural surfactants for the green approach in the preparation of nanoparticles. Numerous bio-molecules are present in the plants. Also, numerous plant extract-based MNPs and MONPs have been synthesized and used in several fields of applications particularly in biomedicine. This property can be attributed because of their low cost, biocompatibility and favourable to the environment. In the past few years, the utilisation of these biogenic nanoparticles has in-creased tremendously particularly in cancer therapy. These biogenic nanoparticles considered as an excellent tool for cancer diagnosis and drug delivery at the tumour site preferentially. By utilising the unique properties of nanoparticles and antioxidant and antitumor nature of plants, these biosynthesised nanoparticles selectively destroy the tumour cells and do not harm the normal healthy cells. In this review, we have compiled the most significant results obtained by the biosynthesized MNPs and MONPs like silver (Ag), gold (Au), Fe2O3/Fe3O4, ZnO, and CuO respectively.

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Green synthesis of gold nanoparticles using a Cordyceps militaris extract and their antiproliferative effect in liver cancer cells (HepG2)

Abstract: View related articlesView Crossmark data Citing articles: 8 View citing articlesGreen synthesis of gold nanoparticles using a Cordyceps militaris extract and their antiproliferative effect in liver cancer cells (HepG2)

Cited by 38 publications

References 33 publications

Green Silver and Gold Nanoparticles: Biological Synthesis Approaches and Potentials for Biomedical Applications

Green Silver and Gold Nanoparticles: Biological Synthesis Approaches and Potentials for Biomedical Applications

Application of Green Gold Nanoparticles in Cancer Therapy and Diagnosis

Biogenic Metal and Metal Oxides Nanoparticles as Anticancer Agent: A Review

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