Green Synthesis of Gold Nanoparticles Using Pomegranate Peel Extract and Its Antioxidant and Anticancer Activity against Liver Cancer Cell Line

Rajeshkumar, S.; Lakshmi, T; Tharani, M; Sivaperumal, P.

doi:10.47059/alinteri/v35i2/ajas20089

Cited by 15 publications

(10 citation statements)

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“…For instance, Elumalai and Velmurugan [98] indicated that the antimicrobial activity of ZnONPs against S. aureus, B. subtilis, P. aeruginosa, P. mirabilis, E. coli, C. albicans and C. tropicalis increased with increasing ZnONPs concentrations. Also, Rajeshkumar et al [99] reported that ZnONPs exhibited substantial antibacterial, antifungal and antioxidant activities opon increasing their concentrations. In addition, Sumanth et al [100] confirmed that ZnONPs produced by Xylaria acuta could proficiently exhibited antimicrobial and anticancer activities in a dose dependent manner.…”

Section: Concentration Of Znonpsmentioning

confidence: 99%

Microbial Mediated Synthesis of Zinc Oxide Nanoparticles, Characterization and Multifaceted Applications

Gomaa

2022

J Inorg Organomet Polym

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Nanoparticles have gained considerable importance compared to bulk counterparts due to their unique properties. Due to their high surface to volume ratio and high reactivity, metallic and metal-oxide nanostructures have shown great potential applications. Among them, zinc oxide nanoparticles (ZnONPs) have gained tremendous attention attributed to their unique properties such as low toxicity, biocompatibility, simplicity, easy fabrication, and environmental friendly. Remarkably, ZnONPs exhibit optical, physical, antimicrobial, anticancer, anti-inflammatory and wound healing properties. These nanoparticles have been applied in various fields such as in biomedicine, biosensors, electronics, food, cosmetic industries, textile, agriculture and environment. The synthesis of ZnONPs can be performed by chemical, physical and biological methods. Although the chemical and physical methods suffer from some disadvantages such as the involvement of high temperature and pressure conditions, high cost and not environmentally friendly, the green synthesis of ZnONPs offers a promising substitute to these conventional methods. On that account, the microbial mediated synthesis of ZnONPs is clean, eco-friendly, nontoxic and biocompatible method. This paper reviews the microbial synthesis of ZnONPs, parameters used for the optimization process and their physicochemical properties. The potential applications of ZnONPs in biomedical, agricultural and environmental fields as well as their toxic aspects on human beings and animals have been reviewed.

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Section: Concentration Of Znonpsmentioning

confidence: 99%

Microbial Mediated Synthesis of Zinc Oxide Nanoparticles, Characterization and Multifaceted Applications

Gomaa

2022

J Inorg Organomet Polym

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“…Thus, they possess anticancer. Because other types have been reported to contain anticancer bioactive compounds, more research should be conducted to determine the potential of E. indica as a source of anticancer bioactive compounds [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53].…”

Section: Resultsmentioning

confidence: 99%

Anti-proliferative Potential of Erythrina indica Leaf Aqueous Extract against Human Breast Cancer Cells

Kumaran

Subramanian

Ezhilarasan

et al. 2021

JPRI

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Introduction: Breast cancer is a type of cancer that arises in the cells of the breast. Breast cancer can develop in either the lobules or the ducts. Breast cancer might develop in the fatty tissue or fibrous connective tissue. Materials and Methods: The effect of Erythrina indica (E.indica) on cell viability was measured by MTT assay. Briefly, the cells (1 × 105 cells/ml) were seeded in a 96 well microtiter plate with replications. Treatment was carried out for 24 with different concentrations (50-300 μg) of E.indica. The percentage of cell viability was calculated and plotted in graph. The cell morphological changes of E. indica leaf aqueous extract treated cells were observed under inverted phase contrast microscopy. Results: The crude extract obtained from E.indica leaf greatly inhibits the cancer cell proliferation in dose dependent manner. We observed IC50 at 100 μg/ml of E. indica leaf aqueous extract treated for 24 hrs in breast cancer cells and also it induces apoptosis, which was confirmed by cell morphological changes evaluated using phase contrast microscope. Conclusion: The results suggest that the E. indica leaf aqueous extract shows the potent anti-proliferative activity against breast cancer cells, and it might be a novel new anticancer drug for cancer therapy.

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“…In vitro cytotoxic effects of copper nanoparticles synthesized from avocado seed extract [12], Green synthesis of copper oxide nanoparticles using tamarind extract and its alpha-amylase inhibitory activity [13], cytotoxic activity study of copper oxide nanoparticle mediated through tamarind extract [14]. Our team has extensive knowledge and research experience that has been translated into high quality publications [15 -20].…”

Section: Manymentioning

confidence: 99%

Green Synthesis of Copper Nanoparticles Using Ginger Oleoresin and Evaluation of its Anticancer Activity against Liver Cancer Cell Line

Kumar

Anitha

Rajeshkumar

et al. 2021

JPRI

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Introduction: Nanotechnology is getting used in developing countries to assist, treat disease, and stop health issues. Nanotechnology in addition to nanomedicine is being applied to or developed for application to a spread of commercial and purification processes. Ginger, scientifically known as Zingiber officinale, belongs to the family Zingiberaceae. Aim: The aim of the study was to green synthesis copper nanoparticles using ginger oleoresin and to evaluate its cytotoxic activity against liver cancer cells. Materials and Methods: The Ginger oleoresin was obtained from Synthite Industries Private Limited, Kerala with a product code: 4010000370 was used for the study. Copper nanoparticles were prepared from oleoresin and confirmed using UV-Visible spectroscopy. The prepared copper nanoparticles were then evaluated for the anticancer effect on liver cancer cells using the method of Mosmann. The cells (1 × 105 cells per ml) were seeded in a 96 well microtiter plate (100 μl per well) with replications. Different concentration (control, 10, 20, 30, 40, and 60 μg/ml) of ginger oleoresins mediated copper nanoparticles were tested for the anticancer activity. The percentage of cell viability was calculated. Results: Dose-dependent anticancer activity was observed with ginger oleoresins mediated copper Nanoparticles. The IC 50 value was 30 mg / ml Conclusion: In the present study, ginger oleoresin showed a good activity cytotoxic effect on liver cancer cell lines. However, more research is needed to understand the underlying mechanisms of the cytotoxic property of the ginger plant.

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Green Synthesis of Gold Nanoparticles Using Pomegranate Peel Extract and Its Antioxidant and Anticancer Activity against Liver Cancer Cell Line

Cited by 15 publications

References 0 publications

Microbial Mediated Synthesis of Zinc Oxide Nanoparticles, Characterization and Multifaceted Applications

Microbial Mediated Synthesis of Zinc Oxide Nanoparticles, Characterization and Multifaceted Applications

Anti-proliferative Potential of Erythrina indica Leaf Aqueous Extract against Human Breast Cancer Cells

Green Synthesis of Copper Nanoparticles Using Ginger Oleoresin and Evaluation of its Anticancer Activity against Liver Cancer Cell Line

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