Green synthesis of lignin-based nanoparticles as a bio-carrier for targeted delivery in cancer therapy

Pathania, Khushboo; Sah, Sangeeta Pilkhwal; Salunke, Deepak B.; Jain, Manish; Yadav, Ashok Kumar; Yadav, Vikramaditya G.; Pawar, Sandip V.

doi:10.1016/j.ijbiomac.2022.12.323

Cited by 17 publications

(5 citation statements)

References 37 publications

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“…Ecological approaches, which are simple and safe, have been developed for the synthesis of LNPs [175]. Green approaches to preparing LNPs include non-solvent nanoprecipitation and ultrasonication [176]. A very simple approach for producing LNPs with wide suitability and high efficiency consists of their processing in aqueous sodium p-toluenesulfonate (pTsONa) solution (APS-LNPs) at different pHs, at room temperature, without any other modifications.…”

Section: Green Approaches To Preparing Lnps and Their Propertiesmentioning

confidence: 99%

Lignins as Promising Renewable Biopolymers and Bioactive Compounds for High-Performance Materials

Vasile

Baican

2023

Polymers

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The recycling of biomass into high-value-added materials requires important developments in research and technology to create a sustainable circular economy. Lignin, as a component of biomass, is a multipurpose aromatic polymer with a significant potential to be used as a renewable bioresource in many fields in which it acts both as promising biopolymer and bioactive compound. This comprehensive review gives brief insights into the recent research and technological trends on the potential of lignin development and utilization. It is divided into ten main sections, starting with an outlook on its diversity; main properties and possibilities to be used as a raw material for fuels, aromatic chemicals, plastics, or thermoset substitutes; and new developments in the use of lignin as a bioactive compound and in nanoparticles, hydrogels, 3D-printing-based lignin biomaterials, new sustainable biomaterials, and energy production and storage. In each section are presented recent developments in the preparation of lignin-based biomaterials, especially the green approaches to obtaining nanoparticles, hydrogels, and multifunctional materials as blends and bio(nano)composites; most suitable lignin type for each category of the envisaged products; main properties of the obtained lignin-based materials, etc. Different application categories of lignin within various sectors, which could provide completely sustainable energy conversion, such as in agriculture and environment protection, food packaging, biomedicine, and cosmetics, are also described. The medical and therapeutic potential of lignin-derived materials is evidenced in applications such as antimicrobial, antiviral, and antitumor agents; carriers for drug delivery systems with controlled/targeting drug release; tissue engineering and wound healing; and coatings, natural sunscreen, and surfactants. Lignin is mainly used for fuel, and, recently, studies highlighted more sustainable bioenergy production technologies, such as the supercapacitor electrode, photocatalysts, and photovoltaics.

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Section: Green Approaches To Preparing Lnps and Their Propertiesmentioning

confidence: 99%

Lignins as Promising Renewable Biopolymers and Bioactive Compounds for High-Performance Materials

Vasile

Baican

2023

Polymers

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“…26 Pathania et al synthesized LNPs and iron oxide nanoparticles using methotrexate and discussed the therapeutic effect of polymer magnetic nanoparticles on cancer diagnosis and treatment. 27 In common biorefinery technologies, lignin is left in the form of solid residues with poor reactivity. For example, the processing of sulfate LNPs requires tedious pretreatment and purification steps.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Due to being nontoxic and having thermal stability, biocompatibility, and biodegradability, lignin can be used as stabilizers, surfactants, additives, adsorbents, and drug delivery carriers. ,, In a previous study, Zhou et al reported a method of amino-functionalized enzymatic lignin self-assembly to produce LNPs and found that it had a good sustained-release effect on doxorubicin hydrochloride . Pathania et al synthesized LNPs and iron oxide nanoparticles using methotrexate and discussed the therapeutic effect of polymer magnetic nanoparticles on cancer diagnosis and treatment . In common biorefinery technologies, lignin is left in the form of solid residues with poor reactivity.…”

Section: Introductionmentioning

confidence: 99%

Integrated Preparation of Hollow Lignin Nanoparticles as a Drug Carrier and Levulinic Acid from the Poplar Wood Prehydrolysis Liquor

Li,

Wang,

Jiang

et al. 2024

Langmuir

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Prehydrolysis liquid (PHL) from dissolving pulp and biorefinery industries is rich in saccharides and lignin, being considered as a potential source of value-added materials and platform molecules. This study proposed an environmentally friendly and simple method to prepare morphologically controllable hollow lignin nanoparticles (LNPs) and levulinic acid (LA) from PHL. In the first step, after hydrothermal treatment of PHL with p-toluenesulfonic acid (p-TsOH), lignin with a uniform molecular weight was obtained to prepare LNPs. The prepared LNPs have an obvious hollow structure, with an average size of 490−660 nm, and exhibit good stability during 30 days of storage. When the as-obtained LNPs were used as a sustained-release agent for amikacin sulfate, the encapsulation efficiency reached over 70% and the release efficiency within 40 h reached 69.2% in a pH 5.5 buffer. Subsequently, the remaining PHL that contains saccharides was directly used for LA production under the catalysis of p-TsOH. At 150 °C for 1.5 h, the LA yield reached 58.4% and remained at 56% after 5 cycles of p-TsOH. It is worth noting that only p-TsOH was used as a reactive reagent throughout the entire preparation process. Overall, this study provided a novel pathway for the integrated utilization of PHL and showed the immense potential of the preparation and application of LNPs.

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“…Lignin-based silver nanoparticles offer several advantages over traditional AgNPs, including enhanced biocompatibility [ 27 ], reduced cytotoxicity [ 28 ], and improved stability [ 29 ]. Furthermore, the functional groups present in lignin can impart additional properties to the nanoparticles, such as improved dispersibility [ 30 ] and targeted delivery [ 31 ]. Despite the promise of lignin-based synthesis of silver nanoparticles, several challenges remain to be addressed.…”

Section: Introductionmentioning

confidence: 99%

Solvent-Induced Lignin Conformation Changes Affect Synthesis and Antibacterial Performance of Silver Nanoparticle

Li,

Chen

2024

Nanomaterials

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The emergence of antibiotic-resistant bacteria necessitates the development of novel, sustainable, and biocompatible antibacterial agents. This study addresses cytotoxicity and environmental concerns associated with traditional silver nanoparticles (AgNPs) by exploring lignin, a readily available and renewable biopolymer, as a platform for AgNPs. We present a novel one-pot synthesis method for lignin-based AgNPs (AgNPs@AL) nanocomposites, achieving rapid synthesis within 5 min. This method utilizes various organic solvents, demonstrating remarkable adaptability to a wide range of lignin-dissolving systems. Characterization reveals uniform AgNP size distribution and morphology influenced by the chosen solvent. This adaptability suggests the potential for incorporating lignin-loaded antibacterial drugs alongside AgNPs, enabling combined therapy in a single nanocomposite. Antibacterial assays demonstrate exceptional efficacy against both Gram-negative and Gram-positive bacteria, with gamma-valerolactone (GVL)-assisted synthesized AgNPs exhibiting the most potent effect. Mechanistic studies suggest a combination of factors contributes to the antibacterial activity, including direct membrane damage caused by AgNPs and sustained silver ion release, ultimately leading to bacterial cell death. This work presents a straightforward, adaptable, and rapid approach for synthesizing biocompatible AgNPs@AL nanocomposites with outstanding antibacterial activity. These findings offer a promising and sustainable alternative to traditional antibiotics, contributing to the fight against antibiotic resistance while minimizing environmental impact.

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Green synthesis of lignin-based nanoparticles as a bio-carrier for targeted delivery in cancer therapy

Cited by 17 publications

References 37 publications

Lignins as Promising Renewable Biopolymers and Bioactive Compounds for High-Performance Materials

Lignins as Promising Renewable Biopolymers and Bioactive Compounds for High-Performance Materials

Integrated Preparation of Hollow Lignin Nanoparticles as a Drug Carrier and Levulinic Acid from the Poplar Wood Prehydrolysis Liquor

Solvent-Induced Lignin Conformation Changes Affect Synthesis and Antibacterial Performance of Silver Nanoparticle

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