Green Synthesis of Metal Nanoparticles and its Reaction Mechanisms

Chokkareddy, Rajasekhar

doi:10.1002/9781119418900.ch4

Cited by 56 publications

(33 citation statements)

References 49 publications

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“…However, it has been suggested that various biomolecules are involved in this process [24,[38][39][40][41][42][43][44][45][46][47][48]. Capping and stabilizing agents (polysaccharides, polypeptides and other bioorganic compounds) prevent the gNPs from further growth and agglomeration in resulted colloidal solution [45][46][47][48][49][50][51]. Extracellular synthesis of gNPs usually occurs when microbial cells secrete reductive enzymes on the surface of cell wall or outside the cell [43,[45][46][47][48].…”

Section: Introductionmentioning

confidence: 99%

“…Capping and stabilizing agents (polysaccharides, polypeptides and other bioorganic compounds) prevent the gNPs from further growth and agglomeration in resulted colloidal solution [45][46][47][48][49][50][51]. Extracellular synthesis of gNPs usually occurs when microbial cells secrete reductive enzymes on the surface of cell wall or outside the cell [43,[45][46][47][48]. This process mediated through different enzymes, including hydrogenases [40], nitrate reductase [48], phenol-oxidizing enzymes (laccases, tyrosinases, and Mn-peroxidases) [43], as well as adhesins [49], has been described.…”

Section: Introductionmentioning

confidence: 99%

“…This process mediated through different enzymes, including hydrogenases [40], nitrate reductase [48], phenol-oxidizing enzymes (laccases, tyrosinases, and Mn-peroxidases) [43], as well as adhesins [49], has been described. In addition to the reducing extracellular metabolites, the cell wall of microorganisms seems to play an important role in the intracellular synthesis of NPs [8,27,[44][45][46][47]. It interacts electrostatically with metal ions and traps them in the process.…”

Section: Introductionmentioning

confidence: 99%

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Metallic Nanoparticles Obtained via “Green” Synthesis as a Platform for Biosensor Construction

et al. 2019

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Novel nanomaterials, including metallic nanoparticles obtained via green synthesis (gNPs), have a great potential for application in biotechnology, industry and medicine. The special role of gNPs is related to antibacterial agents, fluorescent markers and carriers for drug delivery. However, application of gNPs for construction of amperometric biosensors (ABSs) is not well documented. The aim of the current research was to study potential advantages of using gNPs in biosensorics. The extracellular metabolites of the yeast Ogataea polymorpha were used as reducing agents for obtaining gNPs from the corresponding inorganic ions. Several gNPs were synthesized, characterized and tested as enzyme carriers on the surface of graphite electrodes (GEs). The most effective were Pd-based gNPs (gPdNPs), and these were studied further and applied for construction of laccase- and alcohol oxidase (AO)-based ABSs. AO/GE, AO-gPdNPs/GE, laccase/GE and laccase-gPdNPs/GE were obtained, and their analytical characteristics were studied. Both gPdNPs-modified ABSs were found to have broader linear ranges and higher storage stabilities than control electrodes, although they are less sensitive toward corresponding substrates. We thus conclude that gPdNPs may be promising for construction of ABSs for enzymes with very high affinities to their substrates.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Metallic Nanoparticles Obtained via “Green” Synthesis as a Platform for Biosensor Construction

et al. 2019

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“…Afterward, the nanoparticles joint to form different morphology shapes such as, spheres, hexagons, triangles, cubes, ovale, etc. [43].…”

Section: Mechanisms Of Nanoparticle Biosynthesis By Microorganismsmentioning

confidence: 99%

Biological Synthesis of Nanoparticles Using Endophytic Microorganisms: Current Development

Messaoudi¹,

Bendahou²

2020

Nanotechnology and the Environment

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Nanotechnology is a new emerging interdisciplinary approach created by pairing of engineering, chemical, and biological approaches. This technology produces nanoparticles using different methods of traditional physical and chemical processes; however, the outlook in this field of research is to use ecofriendly, nontoxic, and clean methods for the synthesis of nanoparticles. Biological entities, such as plants, bacteria, fungi, algae, yeast, and actinomycetes, are the best candidate to achieve this goal. Among the biological route, those involve endophtic microorganisms to reduce metallic ions into nanoparticles. This method is considered as an attractive option and can open a new horizon on the interface of biology and nanotechnology. The present chapter highlights the latest research about endophytic microorganisms and their application in the synthesis of nanoparticles, as well as the mechanisms involved in the formation of nanoparticles.

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“…There are various kinds of bio‐platforms applying in green synthesis of nanomaterials including fungi, algae, bacteria, and plants. They could be able to produce highly pure values of nanoparticles such as zinc oxide nanoparticles (ZnO NPs) . Regarding the ZnONPs particle size, they significantly exhibit antioxidant, antitumor, and cytotoxic activity in the various types of tumors including hepatocytes, prostate, human alveolar, and breast cancer …”

Section: Introductionmentioning

confidence: 99%

Green‐synthesized Zinc oxide nanoparticle, an efficient safe anticancer compound for human breast MCF7 cancer cells

Salari

Neamati

Tabrizi

et al. 2019

Applied Organom Chemis

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There are many types of researches investigating anticancer therapeutics for breast cancer therapy. Zinc oxide nanoparticles (ZnONPs) as an efficient drug delivery system, has been widely being used in various biomedical applications. In the current study, we synthesized ZnONP applying Rheum rhaponticum Waste (RRW) as a novel bio‐platform to investigate its anticancer impacts on MCF7 breast cancer cells compared with normal Human HFF and HDF cells. In this regard, RRW was triggered to synthesize the ZnONPs. Then, they were characterized by XRD, FTIR, TEM, and SEM analysis. Next, the MCF‐7, HFF, and HDF cell lines were cultured and treated as the following plane: Incubation of all cell lines for 72, 48, and 24 hours at the presence of different ZnONPs doses. Finally, the cell morphology, BCL2‐ BAX genes expression profile and AO/PI‐fluorescent cell staining on the 48‐hour incubated cells were analyzed to check the ZnONP apoptotic activity. Moreover, the ZnONP antioxidant activity was analyzed by a DPPH antioxidant test. We produced the 30 nm ZnONPs which significantly increased the BAX and decreased the BCL‐2 gene expression. According to the results including the Sub G1 enhancement peaks, apoptotic hallmarks, MTT assay, and the AO/PI‐fluorescent stained cells, ZnONPs can specifically induce apoptotic death in MCF7 breast cancer cells compared with normal HFF and HDF cells. The IC50 values of MCF‐7 in 72, 48, and 24 hr were measured at 8, 11, and 12 μg/ml in 72, 48, and 24 hr, respectively. This is while the mentioned values in the normal cells (HFF, HDF) were estimated at higher treatment doses. In conclusion, we suggest that the ZnONPs have the potential to be applied as a safe cell‐specific apoptosis inducer in breast cancer treatment. However, there are many challenges that need to be clarified for applying them as an efficient anticancer agent.

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Green Synthesis of Metal Nanoparticles and its Reaction Mechanisms

Cited by 56 publications

References 49 publications

Metallic Nanoparticles Obtained via “Green” Synthesis as a Platform for Biosensor Construction

Metallic Nanoparticles Obtained via “Green” Synthesis as a Platform for Biosensor Construction

Biological Synthesis of Nanoparticles Using Endophytic Microorganisms: Current Development

Green‐synthesized Zinc oxide nanoparticle, an efficient safe anticancer compound for human breast MCF7 cancer cells

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