Green Synthesis of Metallic Silver Nanoparticles Using Curculigo orchioides Rhizome Extracts and Evaluation of Its Antibacterial, Larvicidal, and Anticancer Activity

Thamilchelvan, Kayalvizhi; Ravikumar, S.; Venkatachalam, P.

doi:10.1061/(asce)ee.1943-7870.0001098

Cited by 42 publications

(14 citation statements)

References 34 publications

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“…Earlier studies have suggested that intervention with curcumin loaded nanoparticulate systems presents several benefits, including improved solubility, enhanced drug uptake, and site-specific delivery.10 In recent years, plant-mediated biosynthesis of silver nanoparticles (AgNPs) has received considerable attention owing to its simple, non-toxic and eco-friendly way of synthesis. The method of green synthesis of AgNPs, using plant extracts not only make them more sustainable and biocompatible11–13 but it may also result in functionalization of the nanoparticles, which could further enhance their anti-cancer activity.14…”

Section: Introductionmentioning

confidence: 99%

<p>Effects of green synthesised silver nanoparticles (ST06-AgNPs) using curcumin derivative (ST06) on human cervical cancer cells (HeLa) in vitro and EAC tumor bearing mice models</p>

Murugesan¹,

Koroth²,

Srinivasan³

et al. 2019

IJN

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Background In recent years, green synthesized silver nanoparticles have been increasingly investigated for their anti-cancer potential. In the present study, we aimed at the biosynthesis of silver nanoparticles (AgNPs) using a curcumin derivative, ST06. Although, the individual efficacies of silver nanoparticles or curcumin derivatives have been studied previously, the synergistic cytotoxic effects of curcumin derivative and silver nanoparticles in a single nanoparticulate formulation have not been studied earlier specifically on animal models. This makes this study novel compared to the earlier synthesized curcumin derivative or silver nanoparticles studies. The aim of the study was to synthesize ST06 coated silver nanoparticles (ST06-AgNPs) using ST06 as both reducing and coating agent. Methods The synthesized nanoparticles AgNPs and ST06-AgNPs were characterised for the particle size distribution, morphology, optical properties and surface charge by using UV-visible spectroscopy, dynamic light scattering (DLS) and transmission electron microscopy (TEM). Elemental composition and structural properties were studied by energy dispersive X-ray spectroscopy (EDX) and X-ray diffraction spectroscopy (XRD). The presence of ST06 as capping agent was demonstrated by Fourier transform infrared spectroscopy (FTIR). Results The synthesized nanoparticles (ST06-AgNPs) were spherical and had a size distribution in the range of 50–100 nm. UV-Vis spectroscopy displayed a specific silver plasmon peak at 410 nm. The in vitro cytotoxicity effects of ST06 and ST06-AgNPs, as assessed by MTT assay, showed significant growth inhibition of human cervical cancer cell line (HeLa). In addition, studies carried out in EAC tumor-induced mouse model (Ehrlich Ascites carcinoma) using ST06-AgNPs, revealed that treatment of the animals with these nanoparticles resulted in a significant reduction in the tumor growth, compared to the control group animals. Conclusion In conclusion, green synthesized ST06-AgNPs exhibited superior anti-tumor efficacy than the free ST06 or AgNPs with no acute toxicity under both in vitro and in vivo conditions. The tumor suppression is associated with the intrinsic apoptotic pathway. Together, the results of this study suggest that ST06-AgNPs could be considered as a potential option for the treatment of solid tumors.

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Section: Introductionmentioning

confidence: 99%

<p>Effects of green synthesised silver nanoparticles (ST06-AgNPs) using curcumin derivative (ST06) on human cervical cancer cells (HeLa) in vitro and EAC tumor bearing mice models</p>

Murugesan¹,

Koroth²,

Srinivasan³

et al. 2019

IJN

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“…9. Some other authors also stated that gram-positive bacteria were more sensitive to AgNPs compared to gram-negative bacteria [29,30] . Depending upon the concentration of AgNPs exposed to bacteria and the type of bacteria, different inhibition zones are formed and along with that the structural and molecular compositions of bacterial species [31] and inoculated concentration of bacteria and the size, shape, concentrations of AgNPs contribute to the varying results of inhibition zones [32] .…”

Section: Resultsmentioning

confidence: 99%

Seed Extract-mediated Synthesis of Silver Nanoparticles from Putranjiva roxburghii Wall., Phytochemical Characterization, Antibacterial Activity and Anticancer Activity Against MCF-7 Cell Line

Nayaka¹,

Bhat²,

Chakraborty³

et al. 2020

pharmaceutical-sciences

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“…Moreover, the polysaccharides significantly up-regulated the expression of caspase-3, caspase-9 and p53 protein in HeLa cells in vitro [ 27 ]. The silver nanoparticles (CoBAgNPs) prepared from C. orchioides rhizome extracts in vitro showed an inhibitory effect against human breast cancer cell lines (MDA-MB-231) and Vero cell lines with the IC 50 values as 18.86 μg/mL and 42.43 μg/mL, respectively [ 82 ]. In another study conducted by Selvaraj and Agastian (2017), the ethyl acetate extract and silver nanoparticles (80 μg/mL) synthesized from C. orchioides exhibited maximum growth inhibitory effects against human breast cancer cells (MCF-7) with a rate of 66.12% and 71.28% [ 83 ].…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Phytochemistry and Pharmacological Activity of Plants of Genus Curculigo: An Updated Review Since 2013

Wang

2021

Molecules

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The genus Curculigo, as a folk herbal medicine, has been used for many years in China, treating impotence, limb limpness, and arthritis of the lumbar and knee joints. The last systematic review of the genus Curculigo was written in 2013, scientifically categorizing the phytochemistry and biological activities. Hitherto, the original compounds and their pharmacological activities were presented as the development of this genus, but there is not an updated review. To conclude the progression of the genus Curculigo, we collected the new literature published from 2013 to 2021 in PubMed, Web of Science, Google Scholar databases, and the Chinese National Knowledge Infrastructure. The novel chlorophenolic glucosides, curculigine, phenolic glycosides, orcinosides and polysaccharides were isolated from Curculigo. The new analyzing methods were established to control the quality of Curculigo as a herbal medicine. In addition, the pharmacological effects of Curculigo focused on anti-diabetes, antibacterial, anti-inflammatory, osteoporosis, antioxidation, etc. The antitumor and neuroprotective activities were newly explored in recent years. The application of herbal medicine was gradually developed in scientific methods. The medicinal value of the genus Curculigo needs to further investigate its pharmacological mechanisms. This new review offers more insights into the exploitation of the pharmacological value of the genus Curculigo.

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Green Synthesis of Metallic Silver Nanoparticles Using Curculigo orchioides Rhizome Extracts and Evaluation of Its Antibacterial, Larvicidal, and Anticancer Activity

Cited by 42 publications

References 34 publications

<p>Effects of green synthesised silver nanoparticles (ST06-AgNPs) using curcumin derivative (ST06) on human cervical cancer cells (HeLa) in vitro and EAC tumor bearing mice models</p>

<p>Effects of green synthesised silver nanoparticles (ST06-AgNPs) using curcumin derivative (ST06) on human cervical cancer cells (HeLa) in vitro and EAC tumor bearing mice models</p>

Seed Extract-mediated Synthesis of Silver Nanoparticles from Putranjiva roxburghii Wall., Phytochemical Characterization, Antibacterial Activity and Anticancer Activity Against MCF-7 Cell Line

Phytochemistry and Pharmacological Activity of Plants of Genus Curculigo: An Updated Review Since 2013

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