Green synthesis of metronidazole or clindamycin-loaded hexagonal zinc oxide nanoparticles from Ziziphus extracts and its antibacterial activity

Abstract

Green chemistry has become a fruitful approach for the synthesis of semiconductors and nanoparticles with various applications. Herein, we synthesized ZnO hexagonal nanoparticles (HNPs) by green precipitation method using fresh local Ziziphus leaf extract (Rhamnaceae) with a heating range of 60–80 in an alkaline medium. It was calcinated on a furnace at 500 °C for 2 h. to get a very fine and homogeneous pale-yellow powder which is then loaded with either metronidazole or clindamycin. The physical characterizations of the particles’ morphology, size, and purity were measured using the Scanning electron microscope, UV-spectroscopy, and the Fourier transform infrared spectroscope. The size of ZnO nanoparticles (44.63 nm) was measured using scanning electron microscopy (SEM), and the mean crystal size of the precursor (17.37 nm) was measured using X-ray diffraction methods (XRD). The antibacterial activity of these particles was measured against Staphylococcus aureus bacterial strains and analyzed using a “well-diffusion technique” which revealed that metronidazole or clindamycin-containing ZnO nanoparticles showed good bactericidal activity. Keywords

Visible Light Activated Fe-N-SiO2/TiO2 Photocatalyst: Providing an Opportunity for Enhanced Photocatalytic Degradation of Antibiotic Oxytetracycline in Aqueous Solution

“…As observed in Figure 5(a), the sizes of the nanoparticles were in the range of 22.14-50.87 nm. As an extra provision to calculate the size of the catalyst, Figure 5b presented the particle size distribution of Fe-N-SiO2/TiO2 nanoparticles in the range of 10 to 45 nm, in which the most common size range included the values from 26 to 30 nm [42]. The SEM results are the clear evidence that the uniformly distributed nanoparticles are spherical in shape.…”