Green synthesis of novel pyrazole carbonitrile and aryl methylene-pyrazole derivatives using 2-aminopyridine-Functionalized Silica-Coated Fe3O4 Nanoparticles as a highly-efficient and magnetically Separable Catalyst (Fe3O4@SiO2/NH/CC/2APy/CuII)

Abstract

A novel catalyst namely, Fe3O4@SiO2/Si(OEt)(CH2)3NH/CC/2-aminopyridine/Cu(OAc)2, abbreviated (Fe3O4/SiO2/NH/CC/2APy/CuII) was designed and prepared. In this study, we show that Copper(II) acetate complex-based 2-amino pyridine coated on Fe3O4 magnetic nanoparticles as an effective and Magnetically Separable nanocatalyst by a low-cost and simple procedure. The morphology and structure of Fe3O4/SiO2/NH/CC/2APy/CuII were studied and characterized using several techniques. Nanocatalysts synthesized (Fe3O4/SiO2/NH/CC/2APy/CuII) in very simple ways are separated by an external magnet for five runs, according to the results, no significant reduction in reaction yields was observed. Catalytic studies revealed that the Fe3O4/SiO2/NH/CC/2APy/CuII catalyst is a highly efficient and green nanocatalyst for the synthesis of pyrazole carbonitrile and aryl methylene-pyrazol. The use of synthetic catalyst in this method has many advantages, including high efficiency, simple method, short reaction time, and easy recovery of the catalyst.

Magnetic Nanoparticles‐Supported Synthesis of Pyrazole Scaffolds: A Review

“…A new catalyst, denoted as Fe 3 O 4 @SiO 2 /Si(OEt)(CH 2 ) 3 NH/CC/ 2-aminopyridine/Cu(OAc) 2 and shortened as Fe 3 O 4 /SiO 2 /NH/CC/ 2APy/CuII, was developed and synthesized by Ghanbarpour et al [122] This study demonstrates the efficacy of a copper (II) acetate complex-based 2-amino pyridine coating on Fe 3 O 4 magnetic nanoparticles as a highly efficient and easily separable nanocatalyst. The nanocatalysts (Fe 3 O 4 /SiO 2 /NH/CC/2APy/CuII) were manufactured using a straightforward method and subsequently separated by means of an external magnet for five consecutive runs (Table 43).…”