Green Synthesis of Oxovanadium(IV)/chitosan Nanocomposites and Its Ameliorative Effect on Hyperglycemia, Insulin Resistance, and Oxidative Stress

Liu, Yanjun; Xu, Jie; Guo, Yongli; Zhang, Xin; Xue, Changhu

doi:10.1007/s12011-015-0420-6

Cited by 6 publications

(4 citation statements)

References 40 publications

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“…Several studies have shown that vanadium complexes with organic ligands are more active than inorganic salts and that they are not associated with adverse effects on the gastrointestinal tract [ 47 , 48 ]. Therefore, in our previous study, the influence of three organic vanadium complexes—sodium (2,2′-bipyridine)oxidobisperoxovanadate (V) octahydrate, bis(2,2′-bipyridine)oxidovanadium (IV) sulfate dehydrate, and bis(4,4′-dimethyl-2,2′-bipyridine)oxidovanadium (IV) sulfate dihydrate—on lipid metabolism under the condition of a high-fat diet in a non-diabetes animal model was analyzed [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…Liu et al [ 48 ], also researched the influence of IV oxidation state vanadium complexes (oxovanadium (IV)/chitosan nanocomposites and the vanadyl (IV)–ascorbate complex) combined with high-fat and high-sucrose diets on the oxidative stress in liver tissue. The vanadium complexes analyzed significantly increased the antioxidant status in the liver tissue [ 47 , 48 ]. Xie et al [ 60 ], also noted the influence of an organic vanadium complex (a vanadium-chlorodipicolinate compound) on changes in the activity of selected antioxidative parameters in the livers of streptozotocin-diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

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The Influence of Organic Vanadium Complexes on an Antioxidant Profile in Adipose Tissue in Wistar Rats

et al. 2022

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One of the aspects of biological activity of vanadium is its influence on carbohydrate metabolism. For more than 30 years, various vanadium complexes have been tested as antidiabetic agents. This study researched organic vanadium complexes with bipyridinium ligands and their influences on metabolic rate, as well as on the antioxidant activity of adipose tissue. The effects of sodium (2,2′-bipyridine) oxidobisperoxovanadate (V) octahydrate (known as the V complex), bis(2,2′-bipyridine) oxidovanadium (IV) sulfate dehydrate (known as the B complex), and bis(4.4′-dimethyl-2,2′-bipyridine) oxidovanadium (IV) sulfate dihydrate (labelled as the BM complex) were assessed. Solutions of the tested complexes were introduced intraperitoneally with a probe to animals fed with either a control diet or a high-fat diet. The BM complex had a significant influence on the increase in ferric reducing antioxidant power, as well as on the concentration of glutathione in the adipose tissue of rats fed with a high-fat diet. The V complex increased the concentration of glutathione in the adipose tissue of rats fed with control fodder, as well as significantly reduced the relative change in rat weight for the high-fat diet. Furthermore, the presence of each tested vanadium complex had an impact of statistically significant increase in basal metabolic rate, regardless of applied diet. Further research on these organic vanadium complexes is necessary to understand the mechanisms responsible for their ability to affect adipose tissue.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Influence of Organic Vanadium Complexes on an Antioxidant Profile in Adipose Tissue in Wistar Rats

et al. 2022

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“…One way to potentially overcome issues surrounding the off-target toxicity of ligands and oxidovanadium itself, is to package oxidovanadium compounds into nanoparticles or nanocomposites that can be passively or actively targeted to cells. For example, packaging of vanadate with chitosan into nanocomposite carriers has been demonstrated, and these have been used for diabetes studies [ 123 , 124 ], whereas Kremer and co-workers have successfully crosslinked oxidovanadium into complexes with anionic polysaccharides [ 125 ]. Chen et al were able to package vanadium disulphide nanodots into PEG lipid micelles, which displayed high tumour uptake in tumour-bearing mice [ 126 ].…”

Section: Future Of Vanadium Researchmentioning

confidence: 99%

Vanadium Compounds as PTP Inhibitors

Irving

Stoker

2017

Molecules

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Phosphotyrosine signaling is regulated by the opposing actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). Here we discuss the potential of vanadium derivatives as PTP enzyme inhibitors and metallotherapeutics. We describe how vanadate in the V oxidized state is thought to inhibit PTPs, thus acting as a pan-inhibitor of this enzyme superfamily. We discuss recent developments in the biological and biochemical actions of more complex vanadium derivatives, including decavanadate and in particular the growing number of oxidovanadium compounds with organic ligands. Pre-clinical studies involving these compounds are discussed in the anti-diabetic and anti-cancer contexts. Although in many cases PTP inhibition has been implicated, it is also clear that many such compounds have further biochemical effects in cells. There also remain concerns surrounding off-target toxicities and long-term use of vanadium compounds in vivo in humans, hindering their progress through clinical trials. Despite these current misgivings, interest in these chemicals continues and many believe they could still have therapeutic potential. If so, we argue that this field would benefit from greater focus on improving the delivery and tissue targeting of vanadium compounds in order to minimize off-target toxicities. This may then harness their full therapeutic potential.

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“…We further hypothesised that hydrophobicity would offer an alternative delivery route for such complexes using nanotechnology. Nanocomposite carriers containing metavanadate and chitosan have been used in mouse models of type 2 diabetes 30 , 31 , while polyethylene glycol (PEG) lipid micelles containing vanadium disulphide nanodots displayed tumour uptake in mice for image-guided photo thermal cancer therapy 30 – 32 . Although at the time of our study there were no examples of nanotechnology being used to deliver larger oxidovanadium complexes, we considered that liposomes would offer a good delivery vehicle due to the hydrophobicity of the complexes.…”

Section: Introductionmentioning

confidence: 99%

The liposomal delivery of hydrophobic oxidovanadium complexes imparts highly effective cytotoxicity and differentiating capacity in neuroblastoma tumour cells

Irving

Tagalakis

Maeshima

et al. 2020

Sci Rep

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Oxidovanadium complexes with organic ligands are well known to have cytotoxic or differentiating capabilities against a range of cancer cell types. Their limited use in clinical testing though has resulted largely from uncertainties about the long-term toxicities of such complexes, due in part to the speciation to vanadate ions in the circulation. We hypothesised that more highly stable complexes, delivered using liposomes, may provide improved opportunities for oxidovanadium applications against cancer. In this study we sourced specifically hydrophobic forms of oxidovanadium complexes with the explicit aim of demonstrating liposomal encapsulation, bioavailability in cultured neuroblastoma cells, and effective cytotoxic or differentiating activity. Our data show that four ethanol-solubilised complexes with amine bisphenol, aminoalcohol bisphenol or salan ligands are equally or more effective than a previously used complex bis(maltolato)oxovanadium(V) in neuroblastoma cell lines. Moreover, we show that one of these complexes can be stably incorporated into cationic liposomes where it retains very good bioavailability, apparently low speciation and enhanced efficacy compared to ethanol delivery. This study provides the first proof-of-concept that stable, hydrophobic oxidovanadium complexes retain excellent cellular activity when delivered effectively to cancer cells with nanotechnology. This offers the improved prospect of applying oxidovanadium-based drugs in vivo with increased stability and reduced off-target toxicity.

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Green Synthesis of Oxovanadium(IV)/chitosan Nanocomposites and Its Ameliorative Effect on Hyperglycemia, Insulin Resistance, and Oxidative Stress

Cited by 6 publications

References 40 publications

The Influence of Organic Vanadium Complexes on an Antioxidant Profile in Adipose Tissue in Wistar Rats

The Influence of Organic Vanadium Complexes on an Antioxidant Profile in Adipose Tissue in Wistar Rats

Vanadium Compounds as PTP Inhibitors

The liposomal delivery of hydrophobic oxidovanadium complexes imparts highly effective cytotoxicity and differentiating capacity in neuroblastoma tumour cells

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