Green Synthesis of Platinum Nanoparticles for Biomedical Applications

Михайлова, Е. О.

doi:10.3390/jfb13040260

Cited by 19 publications

(9 citation statements)

References 202 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The green synthesis of the Centella asiatica -mediated SeO-NPs showed a color change from black to brown, which can be compared with a similar study, wherein the synthesis of Se-NPs mediated by Ceropegia bulbosa Roxb extract showed a color change from yellow to ruby red [ 21 ]. Hence, various biomolecules found in plants, such as proteins, enzymes, flavonoids, terpenoids, phenolic compounds, and organic acids, among other compounds, are involved in the synthesis and packaging of nanoparticles [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antibacterial Efficacy of Centella asiatica-Mediated Selenium Oxide Nanoparticles Against Multidrug-Resistant Upper Respiratory Isolates

Nataraj,

Carmelin,

Geetha Sravanthy

et al. 2024

Cureus

View full text Add to dashboard Cite

Background The evolution of new respiratory diseases, especially upper respiratory tract infections and resistance of pathogens to various antibiotic treatments, needs an alternative way of medication. Chronic respiratory infections in both adults and infants are the major cause of morbidity and mortality, particularly in developing countries. The widespread application of nanomaterials in the field of medicine and the incorporation of nanoparticles in drugs are taken into account. These nanomaterials are involved along with the biosynthesis of plant extract. In this study, selenium oxide nanoparticles (SeO-NPs), known as a significant trace element for human health, were synthesized in an eco-friendly manner. Methodology Green synthesis of Centella asiatica -mediated SeO-NPs was proceeded by titration method and nanoparticles were synthesized. The color intensity, morphological characters, functional properties, and involvement of phytochemical compounds were studied by using UV-visible spectroscopy (UV-Vis), Fourier-transform infrared spectroscopy (FT-IR), X-ray powder diffraction (XRD), scanning electron microscope (SEM), and energy-dispersive X-ray spectroscopy (EDX) analysis. Results The synthesized extract showed a color change from brown to ruby red. Results obtained by characterization and biological assays depicted that the Centella asiatica-mediated SeO-NPs showed absorbance at the peak level 320 nm by UV-Vis spectroscopy, several phytochemical compounds, and O-H functional groups by FT-IR which may be involved in the reduction of the selenium oxide nanoparticles. The XRD showed 57.1% crystalline and 42.6% amorphous nature. The SEM images showed that agglomerated spherical shapes were involved in biological activities. The EDX analysis showed the presence of Se, C, and O compounds. Further, the antibacterial activity of the synthesized nanoparticles showed significant activity in the multidrug-resistant respiratory pathogens. Conclusions Based on the characterization studies and biomedical assays, it can be concluded that the incorporation of SeO-NPs along with the plant extract serves as the best remedy and organic treatment for upper respiratory tract infections. We plan to conduct further in-vivo, toxicity-level studies, and clinical trials.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of Antibacterial Efficacy of Centella asiatica-Mediated Selenium Oxide Nanoparticles Against Multidrug-Resistant Upper Respiratory Isolates

Nataraj,

Carmelin,

Geetha Sravanthy

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

“…After long‐term exposure of P. aeruginosa to platinum nanoparticles, it was found that oprD was upregulated while mexEF‐oprN was downregulated, facilitating the intracellular accumulation of antibiotics and reducing the resistance of P. aeruginosa to imipenem and ciprofloxacin (Zhou et al., 2023 ). Since platinum nanoparticles are widely utilized in medical applications (Mikhailova, 2022 ), the combination of platinum nanoparticles and traditional antibiotics provides a promising approach to combat antibiotic‐resistant P. aeruginosa . Probiotics are used as dietary supplements which provide multiple health benefits (Ali et al., 2023 ).…”

Section: Anti‐resistance By Modulating Antibiotic Influx and Efflux M...mentioning

confidence: 99%

Antibiotic influx and efflux in Pseudomonas aeruginosa: Regulation and therapeutic implications

Wu,

Huang,

2024

Microbial Biotechnology

View full text Add to dashboard Cite

Pseudomonas aeruginosa is a notorious multidrug‐resistant pathogen that poses a serious and growing threat to the worldwide public health. The expression of resistance determinants is exquisitely modulated by the abundant regulatory proteins and the intricate signal sensing and transduction systems in this pathogen. Downregulation of antibiotic influx porin proteins and upregulation of antibiotic efflux pump systems owing to mutational changes in their regulators or the presence of distinct inducing molecular signals represent two of the most efficient mechanisms that restrict intracellular antibiotic accumulation and enable P. aeruginosa to resist multiple antibiotics. Treatment of P. aeruginosa infections is extremely challenging due to the highly inducible mechanism of antibiotic resistance. This review comprehensively summarizes the regulatory networks of the major porin proteins (OprD and OprH) and efflux pumps (MexAB‐OprM, MexCD‐OprJ, MexEF‐OprN, and MexXY) that play critical roles in antibiotic influx and efflux in P. aeruginosa. It also discusses promising therapeutic approaches using safe and efficient adjuvants to enhance the efficacy of conventional antibiotics to combat multidrug‐resistant P. aeruginosa by controlling the expression levels of porins and efflux pumps. This review not only highlights the complexity of the regulatory network that induces antibiotic resistance in P. aeruginosa but also provides important therapeutic implications in targeting the inducible mechanism of resistance.

show abstract

“…Obtaining AgNPs is of interest not only as a method and assessment of the level of reducing power, but also as an independent biotechnological process of creating a product (nanoparticles), which can find wide practical applications due to having anticancer effect, antibacterial, antioxidant, anti-inflammatory and anti-hyperglycemic activity [18][19][20][21][22][23][24][25], as well as anti-quorum sensing potential [26]. Advances of such "green" silver, zink, gold, platinum, nickel, aluminum and iron nanoparticles are widely researched [27][28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Optical Characteristics of Silver Nanoparticles Obtained Using Artemisia tilesii Ledeb. "Hairy" Root Extracts With High Flavonoid Content

Bohdanovych

Матвєєва

2023

Innov Biosyst Bioeng

View full text Add to dashboard Cite

Background. "Hairy" roots can be used for production of plant-derived secondary metabolites, such as flavonoids, which have antioxidant and reducing properties. It seems promising to use the process of silver nanoparticles formation as a method of determining the level of reducing power. This approach allows simultaneously to obtain nanoparticles with different biological activity and evaluate the reducing potential of different plants. Objective. The aim of the study was to determine the dependence of optical properties (ultraviolet/visible spectroscopy, UV-Vis spectra) of solutions of silver nanoparticles obtained using wormwood "hairy" root extracts on the content of flavonoids as compounds with reducing activity. Methods. Four Artemisia tilesii “hairy” root lines from the collection of the Institute of Cell Biology and Genetic Engineering NAS of Ukraine were grown for five weeks in liquid 1/2 MS medium with 20 g/l sucrose. "Hairy" roots were homogenized in 70% ethanol, the extracts were centrifuged, total flavonoid content was determined, and extracts were used for the silver nanoparticles preparation via reduction of Ag+ to Ag0 from AgNO3. UV-Vis spectra at 300–600 nm range were recorded right after colloid solution preparation, in five, and in nine days. Results. Total flavonoid content varied from 4.01 ± 0.39 to 15.37 ± 1.08 mg RE/g FW. The UV-Vis spectra curves of absorption increased with the course of time, mostly from day 0 to day 5. At this period, absorption at 370–500 nm wavelength increased almost twofold. The peak absorption of all samples was detected at 440 nm, and the maximum values at the wavelength of 440 nm correlated with the content of flavonoids. This correlation did not change over time. Conclusions. The optical properties of silver nanoparticles colloid solutions obtained using A. tilesii "hairy" root extracts correlated with the total flavonoid content of the samples. Even though the absorbance of the colloid solutions increased with time, those increases correlated with flavonoid content as well. The determination of the optical properties of AgNPs colloid solution can be used as a convenient way of quickly comparing the reducing ability of extracts both right after the formation of a colloidal solution and after some time of its storage.

show abstract

Green Synthesis of Platinum Nanoparticles for Biomedical Applications

Cited by 19 publications

References 202 publications

Evaluation of Antibacterial Efficacy of Centella asiatica-Mediated Selenium Oxide Nanoparticles Against Multidrug-Resistant Upper Respiratory Isolates

Evaluation of Antibacterial Efficacy of Centella asiatica-Mediated Selenium Oxide Nanoparticles Against Multidrug-Resistant Upper Respiratory Isolates

Antibiotic influx and efflux in Pseudomonas aeruginosa: Regulation and therapeutic implications

Optical Characteristics of Silver Nanoparticles Obtained Using Artemisia tilesii Ledeb. "Hairy" Root Extracts With High Flavonoid Content

Contact Info

Product

Resources

About