Green synthesis of pyrido[2,1‐a]isoquinolines and pyrido[1,2‐a]quinolins using Fe₃O₄‐MNPs as efficient nanocatalyst: Study of antioxidant activity

Abstract

In this work, synthesis of pyrido[2,1-a]isoquinolines and pyrido[1,2-a]quinolins in excellent yield using multicomponent reaction of phthalaldehyde, methyl amine, methyl malonyl chloride, alkyl bromides, and triphenylphosphine in the presence of catalytic amount of Fe 3 O 4 -MNPs with aqueous sodium hydroxide at 80°C was investigated. The reduction of ferric chloride solution with Clover Leaf water extract caused to synthesis of magnetic iron oxide nanoparticles (Fe 3 O 4 -MNPs) as a green method. As well, antioxidant activity was studied for the some newly synthesized compounds such as 6a, 6c, 9b, and 9c using the DPPH radical trapping and reducing of ferric ion experiments and comparing results with synthetic antioxidants (TBHQ and BHT). As a result, compounds 6a, 6c, 9b, and 9c show good DPPH radical trapping and excellent reducing strength of ferric ion.