Green synthesis of pyrrolo isoquinolines using in situ synthesis of 4‐hydroxycumarines: Study of antioxidant activity

Abstract

In this research, synthesis of pyrrolo isoquinoline derivatives in excellent yields was performed using the multicomponent reaction of isoquinoline, alkyl bromides, 2‐hydroxyacetophenone, or its derivatives, dimethyl carbonate as a green reagent and KF/clinoptinolite nanoparticles as a catalyst in the aqueous media at 80°C. The Punica granatum peel water extract was used as the green media for the synthesis of PG‐KF/clinoptilolite nanoparticles in high yield. The PG‐KF/clinoptilolite nanoparticles show a significant basic catalytic role in these reactions in preparing the product in high yield and used for several times. In addition, for studying the antioxidant ability of some of the synthesized compounds, diphenyl‐picrylhydrazine (DPPH) radical trapping and power of ferric reduction tests are employed. The short time of the reaction, high yields of the product, easy separation of the catalyst and products are some of the advantages of this procedure.

Recent advances in the synthesis of chromenone fused pyrrolo[2,1-a]isoquinoline derivatives

“…Hossaini et al 76 synthesized pyrrolo isoquinoline derivatives in excellent yields using the multi-component reaction of isoquinoline, alkyl bromides, and 2-hydroxyacetophenone, or its derivatives in the presence of dimethyl carbonate as a green reagent and KF/clinoptilolite nanoparticles as a catalyst in aqueous media at 80 °C (Scheme 18). The protocol of the reactions proceeds through chromenone-fused pyrrolo[2,1- a ]isoquinolines intermediates.…”