Green synthesis of quaternized chitosan nanogel using emulsion-photopolymerization as redox-responsive drug carrier

Lekjinda, Kritsadayut; Sunintaboon, Panya

doi:10.1016/j.carbpol.2022.120495

Cited by 12 publications

(3 citation statements)

References 64 publications

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“…Therefore, it is crucial to develop flexible polymers with multifunctional properties. In recent years, a kind of acrylic organic polymerization monomer (i.e., 2-hydroxyethyl methacrylate and 2-hydroxyethyl acrylate) with good water/organic solubility has been widely concerned because of its characteristics of containing vinyl functional groups in the molecule and being easy to generate active free radical polymerization under light or heat. , In addition, environmentally sensitive flexible hydrogels can be obtained by polymerizing acrylate monomers or copolymerizing with some responsive monomers . Second, introducing organic/inorganic small-molecule antifreeze agents into hydrogels is the most direct and effective strategy to achieve antifreeze hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Zwitterion-Incorporated Antifreeze Hydrogel with Highly Stretchable, Transparent, and Self-Adhesive Properties for Flexible Strain Sensors

Peng,

Hao,

Zhang

et al. 2024

ACS Appl. Polym. Mater.

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Hydrogels are considered to be one of the most promising flexible sensing materials for a variety of practical applications. However, hydrogels usually freeze at temperatures below freezing and lose their inherent properties. Thus, it is highly desirable to prepare hydrogels that can simultaneously have excellent mechanical properties and antifreezing properties at low temperatures. Herein, a facile photoinitiated polymerization strategy is employed to introduce zwitterionic proline (ZP) into the flexible poly(2-hydroxyethyl acrylate) (PHEA) matrix to prepare a stretchable and adhesive PHEA/ZP hydrogel with good freezing-tolerant properties. Due to the presence of abundant hydrogen bonds and electrostatic interaction forces, the obtained PHEA/ZP hydrogel exhibits excellent mechanical properties (stretch of 810%), a self-adhesive nature, high transparency (>90%), and rapid electrical self-healing capability. More importantly, the presence of ZP endows the hydrogel with considerable antifreeze properties, making it completely transparent and stretchable even at −40 °C. In addition, the use of PHEA/ZP hydrogel as a flexible strain sensor can accurately monitor human motions, such as the flexion of human limbs and joint microstress. Therefore, antifreeze hydrogel assisted by zwitterions enables wearable flexible sensors for motion detection at room temperature and low temperature, which has great potential in the field of flexible sensors.

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Section: Introductionmentioning

confidence: 99%

Zwitterion-Incorporated Antifreeze Hydrogel with Highly Stretchable, Transparent, and Self-Adhesive Properties for Flexible Strain Sensors

Peng,

Hao,

Zhang

et al. 2024

ACS Appl. Polym. Mater.

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“…4 Moreover, polysaccharide-derived NGs offer excellent biocompatibility, functionality, adjustable size, ample surface area for bioconjugation, and an inner network that allows for precise regulation of the integration and release of bioactive compounds. 10 Biopolymeric nanocarriers are created using natural polymers, like cellulose, 11 chitosan, 12 sodium alginate, 13 and hyaluronic acid, 14 as well as synthetic polymers, namely polylactic acid (PLA), 15 polyacrylamide (PAA), 16 poly(lactide- co -glycolide) (PLGA), 17 and polyglycolic acid (PGA), 18 dendrimers, 19 among others.…”

Section: Introductionmentioning

confidence: 99%

Smart stimuli-responsive polysaccharide nanohydrogels for drug delivery: a review

Damiri,

Fatimi,

Santos

et al. 2023

J. Mater. Chem. B

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“…UV/laser light is also used for micro/nanostructure or nanocomposite formation in macroscopic hydrogels [15][16][17]. However, there are only few reports on the light-induced synthesis of polymer nanogels [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

“To Be or Not to Be” of a Polymer Nanogel—Unravelling the Relationship of Product Properties vs. Synthesis Conditions Governing the Radiation Crosslinking of Poly(acrylic acid) Using GPC/SEC—MALLS

Kadłubowski,

Rurarz,

Raczkowska

et al. 2023

Materials

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In this paper, a state-of-the-art multi-detection gel permeation chromatography/size exclusion chromatography (GPC/SEC) system including multi-angle laser light scattering (MALLS) is applied to monitor radiation-induced synthesis of internally crosslinked nanostructures from poly(acrylic acid) (PAA). The aim is to demonstrate that this modern tool yields a more detailed picture of reaction mechanism and product structure than the techniques used to date. The prevailing intramolecular crosslinking narrows the molecular weight distribution from Mw/Mn = 3.0 to 1.6 for internally crosslinked structures. A clear trend from over 0.7 to 0.5 in the Mark–Houwink exponent and a decrease in Rg/Rh from 1.7 to 1.0 point to the formation of nanogels, more rigid and less permeable than the starting coils. Changes in the coil contraction factor (g′ = [η]irradiated/[η]linear) as a function of the radical density revealed the existence of two modes in intramolecular crosslinking, the initial one (up to 0.075 radicals per monomer unit) where the compactness of products changes strongly with progressing crosslinking and a second one where further compacting is suppressed by the lower flexibility of the partially crosslinked chain segments. This indicates a transition from soft, still internally crosslinkable nanogels to more rigid structures, less prone to further intramolecular loop formation. Our findings provide means for the tailored design of new PAA nanomaterials.

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Green synthesis of quaternized chitosan nanogel using emulsion-photopolymerization as redox-responsive drug carrier

Cited by 12 publications

References 64 publications

Zwitterion-Incorporated Antifreeze Hydrogel with Highly Stretchable, Transparent, and Self-Adhesive Properties for Flexible Strain Sensors

Zwitterion-Incorporated Antifreeze Hydrogel with Highly Stretchable, Transparent, and Self-Adhesive Properties for Flexible Strain Sensors

Smart stimuli-responsive polysaccharide nanohydrogels for drug delivery: a review

“To Be or Not to Be” of a Polymer Nanogel—Unravelling the Relationship of Product Properties vs. Synthesis Conditions Governing the Radiation Crosslinking of Poly(acrylic acid) Using GPC/SEC—MALLS

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