Green synthesis of silver nanoparticles from medicinal plants and evaluation of their antiviral potential against chikungunya virus

Sharma, Vikrant; Pandit, Pooja; Dhull, Divya; Yadav, Jaya Parkash; Kaushik, Samander

doi:10.1007/s00253-018-9488-1

Cited by 239 publications

(164 citation statements)

References 39 publications

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“…A narrow and symmetrical peak showed that the nanoparticles are monodisperse and spherical [13]. Our results are in favor of some previously published reports [7,27,28].…”

Section: Phytosynthesis Of Agnps (Spectrophotometric Studies)supporting

confidence: 53%

One-pot phytosynthesis of nano-silver from Mentha longifolia L.: their characterization and evaluation of photodynamic potential

Javed

Nadhman

Razzaq

et al. 2020

Mater. Res. Express

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The present study deals with the ecofriendly one-pot synthesis and stabilization of silver nanoparticles (AgNPs) by using aqueous extract of Mentha longifolia branches. Spectrophotometric analysis of different ratios of reactants revealed that a 1 to 9 ratio of plant extract and silver salt solution respectively is the most suitable proportion for synthesis. Synthesis of AgNPs was confirmed initially by the observation of change in the color of the reaction mixture which was carried out at 60°C by using 3 mM of silver salt and the pH of the reaction medium was maintained at 5.22. A characteristic surface plasmon resonance (SPR) band was observed at 495 nm of light wavelength. SEM images revealed that the nanoparticles are in ∼20-80 nm and are anisotropic and nearly spherical while EDX analysis showed the presence of elemental Ag with ∼90% signal intensity. Size distribution analysis of AgNPs was performed by dynamic light scattering technique and AgNPs were found in the range of ∼8-30 nm. ROS quantification revealed that the AgNPs have a quantum yield of 0.09 Φ which provides them the ability to proteolytically treat cancer and other microbial pathogenic cells. AgNPs did not report any photothermal activity to be used as photodynamic agents. These findings explain the redox potential of M. longifolia to bio-fabricate AgNPs and their abilities to generate ROS may help to curb dreading diseases.

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“…A narrow and symmetrical peak showed that the nanoparticles are monodisperse and spherical [13]. Our results are in favor of some previously published reports [7,27,28].…”

Section: Phytosynthesis Of Agnps (Spectrophotometric Studies)supporting

confidence: 53%

One-pot phytosynthesis of nano-silver from Mentha longifolia L.: their characterization and evaluation of photodynamic potential

Javed

Nadhman

Razzaq

et al. 2020

Mater. Res. Express

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“…The natural compounds from Tinospora cordifolia tested in this study showed therapeutically feasible efficacy against SARS-CoV-2 targets involved in attachment of the virus to host receptor (6VSB, 6M0J) and its replication (6M71, 6Y84). Although antiviral properties of Tinospora cordifolia has been reported before against H1N1 and Chikungunya Virus, [5,17,18] .27, 33.39±1.57, 66.79±3.14) against 6VSB was either similar or inferior to the natural compounds from Tinospora cordifolia. [6,10] 6VSB and 6M0J are responsible for viral attachment, while 6Y84 (main Protease) and 6M71 (RNA dependent RNA polymerase) are involved in viral replication.…”

Section: Discussionmentioning

confidence: 74%

“…[13,15,16] The antimicrobial properties of TC extracts is attributed to its phytoconstituents such as furanolactone, tinosporon, jateorine and columbin. [15][16][17] The silver nanoparticles from Tinospora cordifolia were reported to be effective against chikungunya virus. [17] Phytochemicals from TC are also reported be effective inhibitors of H1N1 viral proteins.…”

mentioning

confidence: 99%

“…[15][16][17] The silver nanoparticles from Tinospora cordifolia were reported to be effective against chikungunya virus. [17] Phytochemicals from TC are also reported be effective inhibitors of H1N1 viral proteins. [5] TC is also a vital component of Shilajatu Rasayana (an Ayurvedic preparation), which was reported to synergistically improve efficacy of antiretroviral therapy in HIV positive patients.…”

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confidence: 99%

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Efficacy of natural compounds from Tinospora cordifolia against SARS-CoV-2 protease, surface glycoprotein and RNA polymerase.

Sagar¹,

Kumar

2020

Preprint

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Background: Antiviral activity of natural compounds from Tinospora cordifolia (Amritaballi) were evaluated for their efficacy against SARS-CoV-2 targets involved in virus attachment and replication. Materials and Methods: The binding efficacy (binding affinity, Ki and IC50 values) of natural compounds from Tinospora cordifolia were tested using Insilco tools against four key SARS-CoV-2 targets i.e., 1) surface glycoprotein (6VSB) and 2) Receptor binding domain (6M0J) both responsible for attachment of the virus to host cell, 3) RNA dependent RNA polymerase (6M71) and 4) main protease (6Y84) responsible for replication of the virus in the host cell. Results: Berberine, Isocolumbin, Magnoflorine and Tinocordiside showed high binding efficacy against all the four key SARS-CoV-2 targets. Tinocordiside and Isocolumbin showed IC50 value of < 1 µM against both 6Y84 and 6VSB. Conclusion: At least four natural compounds from Tinospora cordifolia showed high binding efficacy against SARS-CoV-2 targets involved in attachment and replication of the virus. Hence validating the merit of using Tinospora cordifolia in the clinical management of infection caused by SARS-CoV-2.

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“…This background highlights the safety of the use of AuNPs-As as a possible treatment against MeV. The antiviral activity of green synthesized nanoparticles has been mostly focused on the study of silver nanoparticles [27][28][29]. There is also limited information on gold nanoparticles with antiviral activity against enveloped viruses, however, Di Gianvincenzo et al [30] synthesized and evaluated gold nanoparticles coated with multiple copies of an amphiphilic sulfate anti-HIV ligand.…”

Section: Discussionmentioning

confidence: 99%

Virucidal Activity of Gold Nanoparticles Synthesized by Green Chemistry Using Garlic Extract

Meléndez-Villanueva

Morán-Santibañez

José

et al. 2019

Viruses

136

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Measles virus (MeV) is a paramyxovirus that infects humans, principally children. Despite the existence of an effective and safe vaccine, the number of cases of measles has increased due to lack of vaccination coverage. The World Health Organization (WHO) reports that the number of cases worldwide multiplied fourfold between January and March 2019, to 112,000. Today, there is no treatment available for MeV. In recent years, it has been demonstrated that natural extracts (herbal or algal) with antiviral activity can also work as reducing agents that, in combination with nanotechnology, offer an innovative option to counteract viral infections. Here, we synthetized and evaluated the antiviral activity of gold nanoparticles using garlic extract (Allium sativa) as a reducing agent (AuNPs-As). These nanoparticles actively inhibited MeV replication in Vero cells at a 50% effective concentration (EC 50 ) of 8.829 µg/mL, and the selectivity index (SI) obtained was 16.05. AuNPs-As likely inhibit viral infection by blocking viral particles directly, showing a potent virucidal effect. Gold nanoparticles may be useful as a promising strategy for treating and controlling the infection of MeV and other related enveloped viruses.

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Green synthesis of silver nanoparticles from medicinal plants and evaluation of their antiviral potential against chikungunya virus

Cited by 239 publications

References 39 publications

One-pot phytosynthesis of nano-silver from Mentha longifolia L.: their characterization and evaluation of photodynamic potential

One-pot phytosynthesis of nano-silver from Mentha longifolia L.: their characterization and evaluation of photodynamic potential

Efficacy of natural compounds from Tinospora cordifolia against SARS-CoV-2 protease, surface glycoprotein and RNA polymerase.

Virucidal Activity of Gold Nanoparticles Synthesized by Green Chemistry Using Garlic Extract

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