Green Synthesis of Silver Nanoparticles by Plumbago indica and Its Antitumor Activity Against Dalton's Lymphoma Ascites Model

Kumar, T. Sujin Jeba; Balavigneswaran, Chelladurai Karthikeyan; Packiaraj, R.; Veeraraj, A.; Prakash, S.; Hassan, Yehudith; Srinivasakumar, K. P.

doi:10.1007/s12668-013-0102-9

Cited by 16 publications

(5 citation statements)

References 36 publications

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“…The UV-Vis spectra recorded implied that most rapid bioreduction was achieved at 60 • C for the leaf and calyx water extracts. This was denoted by broadening of the peaks that was indicative of the formation of large polydispersed nanoparticles due to slow reduction rates [5]. It was reported that maximum absorption rate for P. capensis aqueous root extract was at 420 nm [21].…”

Section: Resultsmentioning

confidence: 99%

“…Metals used to synthesize nanoparticles include copper, silver, gold, iron oxide, platinum, silica and nickel [3,4]. Due to their unique properties and applications, metal nanoparticles have become quite popular over the years [5,6]. Silver is the most commonly used metal for synthesizing nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

“…Nanostructured systems are believed to potentiate the action of plant extracts, thereby improving their activity and reducing the required dose and possibly reducing adverse side effects [4,13]. Plant-mediated biosynthesis is considered a widely acceptable technology for the rapid production of AgNPs but caution must be given to the type of extraction solvents used because of the hydrophobic nature of the capping agents that are used [5,12].…”

Section: Introductionmentioning

confidence: 99%

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Biosynthesis of silver nanoparticles using Plumbago auriculata leaf and calyx extracts and evaluation of their antimicrobial activities

Singh

Naidoo

Mocktar

et al. 2018

Adv. Nat. Sci: Nanosci. Nanotechnol.

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The use of plants in the biosynthesis of nanoparticles is a fast-growing technique and has gained much interest from researchers over the years. This study reports the utilization of leaf and calyx extracts of Plumbago auriculata for the biosynthesis of silver nanoparticles (AgNPs). The formation of AgNPs which was confirmed by the colour change in the plant extracts was characterized by UV-Vis spectrophotometric, TEM, SEM, EDX and FT-IR analyses. The water-soluble components of the extracts were responsible for the reduction of ions. FT-IR analysis revealed the efficient capping and stabilization properties of these particles and the nature of the capping agent. The antibacterial properties of the biosynthesized AgNPs were evaluated against both gram-negative and gram-positive bacteria and the results obtained showed good antibacterial activity against Klebsiella pneumoniae. This was the first reported study for Plumbago auriculata and contributes to the environmentally friendly and cost-effective technique of the biosynthesis of nanoparticles for drug development.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biosynthesis of silver nanoparticles using Plumbago auriculata leaf and calyx extracts and evaluation of their antimicrobial activities

Singh

Naidoo

Mocktar

et al. 2018

Adv. Nat. Sci: Nanosci. Nanotechnol.

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“…The produced silver NPs possessed an antioxidant activity and antitumor activity against Dalton's Lymphoma as well as antibacterial activity against Gram-positive and Gram-negative bacteria such as Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Klebsiella pneumonia. They also showed larvicidal activity against Aedes aegypti and Culex quinquefasciatus and antitubercular activity against Mycobacterium tuberculosis [3][4][5][6]. Selenium NPs were previously synthesized by green methods using P. zeylanica extract and found to have an antioxidant and antibacterial activities [7].…”

Section: Introductionmentioning

confidence: 99%

Nano Zinc Oxide Green-Synthesized from Plumbago auriculata Lam. Alcoholic Extract

Melk

El‐Hawary

Melek

et al. 2021

Plants

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Zinc oxide nanoparticles (ZnO NPs) were synthesized by using an alcoholic extract of the flowering aerial parts of Plumbago auriculata Lam. Dynamic Light Scattering (DLS) revealed that the average size of synthesized ZnO NPs was 10.58 ± 3.350 nm and the zeta potential was −19.6 mV. Transmission electron microscopy (TEM) revealed that the particle size was in the range from 5.08 to 6.56 nm. X-ray diffraction (XRD) analysis verified the existence of pure hexagonal shaped crystals of ZnO nanoparticles with an average size of 35.34 nm in the sample, which is similar to the particle size analysis acquired by scanning electron microscopy (SEM) (38.29 ± 6.88 nm). HPLC analysis of the phenolic ingredients present in the plant extract showed that gallic acid, chlorogenic acid, and catechin were found as major compounds at concentrations of 1720.26, 1600.42, and 840.20 µg/g, respectively. Furthermore, the inhibitory effects of ZnO NPs and the plant extract against avian metapneumovirus (aMPV) subtype B were also investigated. This assessment revealed that the uncalcinated form of Nano-ZnO mediated by P. auriculata Lam. extract possessed a significant antiviral activity with 50% cytotoxic concentration (CC50) and 50% inhibition concentration (IC50) of 52.48 ± 1.57 and 42.67 ± 4.08 µg/mL, respectively, while the inhibition percentage (IP) was 99% and the selectivity index (SI) was 1.23.

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“…Sliver NPs were previously green-synthesized using various Plumbago species such as P. indica, P. auriculata , and P. zeylanica and proved to possess antioxidant, antitumor, antibacterial, larvicidal and antitubercular properties. 27–30 P. zeylanica was used to synthesize selenium, copper, silver, gold, and bimetallic (silver and gold) NPs. These nanoparticles were found to exhibit antioxidant, antibacterial, 31 antidiabetic, 32 antimicrobial and antibiofilm effects.…”

Section: Introductionmentioning

confidence: 99%

Antiviral Activity of Zinc Oxide Nanoparticles Mediated by Plumbago indica L. Extract Against Herpes Simplex Virus Type 1 (HSV-1)

Melk¹,

El‐Hawary²,

Melek³

et al. 2021

IJN

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Introduction Plumbago indica L. is considered a valuable source in the Plumbaginaceae family for various types of active compound such as alkaloids, phenolics and saponins. To promote the usage of P. indica in the bionanotechnology field, zinc oxide nanoparticles (ZnONPs) were biosynthesized by using its alcoholic extract. The inhibitory effects of ZnONPs and the plant extract were also evaluated against HSV-1. Methods ZnONPs were described by the following techniques, UV–visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), zeta potential, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and x-ray diffraction (XRD). The phenolic and flavonoid contents of P. indica extract, which are accountable for bioreduction, formation and stabilization of the nanoparticles, were analyzed by HPLC technique. The antiviral assessment was implemented on both agents by using Vero cell lines. Results DLS revealed that the average size of ZnONPs was 32.58 ± 7.98 nm and the zeta potential was –20.8 mV. The observation of TEM analysis revealed that the particle size of ZnONPs varied from 2.56 to 8.83 nm. The XRD analysis verified the existence of pure crystals of hexagonal shapes of nanoparticles of ZnO with a main average size of 35.28 nm that is approximating to the values of particle size acquired by SEM analysis (19.64 and 23.21 nm). The HPLC analysis of P. indica ethanolic extract showed that gallic acid, chlorogenic acid and rutin were the major compounds, with concentrations equal to 8203.99, 2965.95 and 1144.99 µg/g, respectively. Regarding the antiviral assessment, the synthesized uncalcinated ZnONPs were found to exhibit a promising activity against HSV-1, with CC 50 and IC 50 values equal to 43.96 ± 1.39 and 23.17 ± 2.29 µg/mL, respectively. Conclusion The green synthesized ZnONPs are considered promising adjuvants to enhance the efficacy of HSV-1 drugs.

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Green Synthesis of Silver Nanoparticles by Plumbago indica and Its Antitumor Activity Against Dalton's Lymphoma Ascites Model

Cited by 16 publications

References 36 publications

Biosynthesis of silver nanoparticles using Plumbago auriculata leaf and calyx extracts and evaluation of their antimicrobial activities

Biosynthesis of silver nanoparticles using Plumbago auriculata leaf and calyx extracts and evaluation of their antimicrobial activities

Nano Zinc Oxide Green-Synthesized from Plumbago auriculata Lam. Alcoholic Extract

Antiviral Activity of Zinc Oxide Nanoparticles Mediated by Plumbago indica L. Extract Against Herpes Simplex Virus Type 1 (HSV-1)

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