Green synthesis of silver nanoparticles using β-glucan, and their incorporation into doxorubicin-loaded water-in-oil nanoemulsions for antitumor and antibacterial applications

Goyal, Girnar; Hwang, Jang‐Sun; Aviral, Jaiswal; Seo, Youngmin; Jo, Yeonho; Son, Jaewoo; Choi, Jonghoon

doi:10.1016/j.jiec.2016.11.029

Cited by 36 publications

(22 citation statements)

References 44 publications

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“…The nano effect of nanoemulsions makes it have high permeability which could easily reach into the cell and bind to DNA or/and enzymes, thus accelerating the death of bacteria. The results verified that the tea oil nanoemulsion with broad spectrum bacteriostatic properties could be used as a multi-functional food ingredient [29][30][31][32].…”

Section: Resultssupporting

confidence: 63%

Preparation, antibacterial and antioxidant properties of green tea seed oil nanoemulsions by self‐emulsification method

Zhu

et al. 2019

Micro & Nano Letters

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Application of tea oil in food products has been gained more and more attention for its nutritional advantages and functional properties. This research fabricated green tea seed oil nanoemulsions by the self-emulsification method through variation of oil and surfactant composition. Finally, in vitro antibacterial assay and antioxidant properties were investigated. The results showed that the sizes could be regulated through surfactant content (5-15 wt%) and composition (HLB 10.72-13.93) from 16.44 ± 0.01 nm to 329 ± 4.74 nm. With the increase of the content of green tea seed oil, the DPPH and total antioxidant capacity of the nanoemulsions were gradually improved. Meanwhile, the antibacterial assay was enhanced as the content of green tea seed oil increased from 0.5 to 1.5%. The inhibition zone increased continually to 7.56 ± 0.40 mm and 6.85 ± 0.59 mm when 1.5% oil was provided. The results could provide a reference to essential oils in the design of functional food-grade ingredients.

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Section: Resultssupporting

confidence: 63%

Preparation, antibacterial and antioxidant properties of green tea seed oil nanoemulsions by self‐emulsification method

Zhu

et al. 2019

Micro & Nano Letters

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“…Surgery, radiation therapy, and chemotherapy are the most common treatments for cancer worldwide, but chemotherapy in particular has various side effects, including strong cytotoxicity caused by the drugs attacking normal cells [1][2][3]. Therefore, many researchers have looked to develop drug formulations that control the rate of release [4][5][6][7] in order to maintain constant concentrations of the drug in the blood or target organ [8].…”

Section: Introductionmentioning

confidence: 99%

NIR Laser-Responsive PNIPAM and Gold Nanorod Composites for the Engineering of Thermally Reactive Drug Delivery Nanomedicine

et al. 2020

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When ingesting a drug on its own or injecting it directly into tissue, its concentration increases immediately within the body, which often exacerbates the side effects and increases its toxicity. To solve this problem, we synthesized the thermally reactive polymer poly(N-isopropylacrylamide) (PNIPAM) using reversible addition–fragmentation chain transfer (RAFT) polymerization and prepared nanocarriers by binding PNIPAM to gold nanorods (GRs), with the anticancer agent doxorubicin (DOX) used as a model drug. PNIPAM changes from hydrophilic to hydrophobic at temperatures above its lower critical solution temperature, which represents a coil-to-globule volume phase transition. Because GRs absorb near-infrared (NIR) laser light and emit energy, PNIPAM aggregation occurs when the synthesized PNIPAM/GR are subjected to an NIR laser, and the temperature of the GRs rises. Using this principle, DOX was combined with the PNIPAM/GR complex, and the resulting anticancer effects with and without laser treatment were observed in Hela and MDA-MB-231 cells. In our proposed complex, the GR binding rate of PNIPAM reached 20% and the DOX binding rate reached 15%. The release profile of the drug following laser irradiation was determined using a drug release test and confocal microscopy imaging. It was subsequently confirmed that the release of the drug is higher at higher temperatures, especially with laser treatment. The proposed combination of temperature-reactive polymers and gold nanostructures shows promise for future research into controlled drug release.

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“…GluNP was prepared according to the previously reported method with a minor modification [14,15]. In brief, glucan powder (Glu, 5 mg) was first dissolved in 1 mL of DMSO at 60 • C for 5 h with stirring to change the triple strands of Glu into random single strands.…”

Section: Synthesis Of Glunp/drug (Inh and Dox)mentioning

confidence: 99%

Quantification of Unknown Nanoscale Biomolecules Using the Average-Weight-Difference Method

et al. 2019

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In order to quantify the amount of drug molecules in drug delivery systems, analytical techniques such as high-performance liquid chromatography are used due to their accuracy and reliability. However, the instruments required for such techniques are expensive and not available in all laboratories. Therefore, in this study, we introduce a method that can be a relatively inexpensive and easy to perform drug analysis in almost any laboratory set-up. We have devised the “average-weight-difference method” within the limits of existing spectral analyses. By employing this method, we quantitatively analyzed the amount of isoniazid or doxorubicin molecules loaded onto β-glucan nanoparticles. This proved to be a relatively simple and reliable method and can be used to estimate the amount of nanoscale biomolecules before their analysis through expensive equipment in an environment where the instruments are not readily available.

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Green synthesis of silver nanoparticles using β-glucan, and their incorporation into doxorubicin-loaded water-in-oil nanoemulsions for antitumor and antibacterial applications

Cited by 36 publications

References 44 publications

Preparation, antibacterial and antioxidant properties of green tea seed oil nanoemulsions by self‐emulsification method

Preparation, antibacterial and antioxidant properties of green tea seed oil nanoemulsions by self‐emulsification method

NIR Laser-Responsive PNIPAM and Gold Nanorod Composites for the Engineering of Thermally Reactive Drug Delivery Nanomedicine

Quantification of Unknown Nanoscale Biomolecules Using the Average-Weight-Difference Method

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