Green Synthesis of Silver Nanoparticles Using Rhazya stricta Decne Extracts and Their Anti-Microbial and Anti-Oxidant Activities

Rahman, Haji; Khan, Shahid Ali; Ahmad, Zubair; Alshammari, Abdulrahman; Alharbi, Metab; Alam, Amir; Suleria, Hafiz Ansar Rasul

doi:10.3390/cryst13030398

Cited by 27 publications

(16 citation statements)

References 43 publications

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“…The majority of DNA and RNA′s chemical components are heterocyclic compounds. The clinical value of heterocyclic compounds captures interest in the synthesis of novel compounds and the investigation of their pharmacological characteristics [6–8] …”

Section: Introductionmentioning

confidence: 99%

Investigating Novel Thiophene Carbaldehyde Based Thiazole Derivatives as Potential Hits for Diabetic Management: Synthesis, In Vitro and In Silico Approach

Ullah,

Alam,

Zainab

et al. 2024

ChemistrySelect

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This research work is based on synthesis of eleven novel thiazole derivatives (3 a‐k) of thiophene carbaldehyde. All the synthesized compounds were successfully synthesized, characterized by 1H‐NMR and EI‐MS spectroscopic techniques and finally subjected for their in vitro α‐glucosidase inhibitory activity. Seven derivatives 3 i (IC50=10.21±1.84 μM), 3 b (IC50=11.14±0.99 μM), 3 f (IC50=13.21±2.76 μM), 3 h (IC50=14.21±0.31 μM), 3 k (IC50=15.21±1.02 μM), 3 e (IC50=16.21±1.32 μM), and 3 c (IC50=18.21±1.89 μM), in the series displayed excellent inhibitory potential better than the standard acarbose. However, two compounds 3 g (IC50=33.21±1.99 μM) and 3 d (IC50=42.31±2.12 μM) showed significant activity while two compounds 3 j and 3 a were found less active with IC50 values of 82.31±0.31 and 88.36±1.21 μM respectively. Additional research revealed that the compounds are not exhibiting any cytotoxic effects. The molecular docking study of these derivatives showed their good binding potential for α‐glucosidase active site with excellent interactions and docking scores.

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Section: Introductionmentioning

confidence: 99%

Investigating Novel Thiophene Carbaldehyde Based Thiazole Derivatives as Potential Hits for Diabetic Management: Synthesis, In Vitro and In Silico Approach

Ullah,

Alam,

Zainab

et al. 2024

ChemistrySelect

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“…However, after 24 h of incubation, no more colour change was noticed. This suggests that the bio‐reduction of Ag + to AgNPs may entail a significant amount of phenols, flavonoids, and other phytochemicals [29].…”

Section: Resultsmentioning

confidence: 99%

“…However, it often requires the use of hazardous chemicals and generates toxic byproducts, making it less environmentally friendly. In contrast, green synthesis methods utilize natural sources such as plant extracts as reducing and stabilizing agents [29]. This approach offers several advantages, including environmental sustainability and biocompatibility.…”

Section: Discussionmentioning

confidence: 99%

Bio‐fabrication of silver nanoparticles using an aqueous extract of Quercus baloot: Preparation, characterization and in vitro antimicrobial evaluation

Rabbi,

Nisar,

Nawaz

et al. 2023

Micro & Nano Letters

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In the current study, a novel method was used to synthesize silver nanoparticles (AgNPs) by utilizing Quercus baloot aqueous extract as a reducing agent. The biosynthesized AgNPs were then subjected to various physicochemical characterizations to assess their effectiveness against microbial familiarity. The characterization techniques included ultraviolet‐visible spectro‐photometry (UV‐Vis), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X‐ray diffractometer (XRD), and Fourier‐transform infrared spectroscopy (FTIR). The UV‐Vis analysis revealed a distinctive spectral peak at 420 nm, indicating the presence of silver nanoparticles. SEM imaging displayed the nanoparticle size range of about 100 nm at a magnification of 30,000x, while TEM demonstrated that the nanoparticles had a spherical morphology with a size of approximately 100 nm. Moreover, the crystalline structure of the silver nanoparticles was confirmed by XRD analysis, further validating their successful synthesis. Additionally, FTIR analysis provided evidence of the presence of phytochemicals involved in synthesizing the AgNPs. the biosynthesized silver nanoparticles (AgNPs) were evaluated for antibacterial and antifungal activities. The AgNPs displayed substantial efficacy against common bacterial strains, including Staphylococcus aureus (71%), Escherichia coli (59%), and Klebsiella pneumoniae (64%). Furthermore, they demonstrated significant antifungal activity against plant pathogenic fungi, namely Aspergillus niger (65%), Aspergillus flavus (70%) and Fusarium oxysporum (61%).

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“…There is a vast number of publications on diverse heterocyclic bioactive compounds. 1,2,4‐Oxadiazole is an interesting heterocyclic scaffold amongst various heterocycles; it plays a major role in design and synthesis of many biologically active compounds [13–35] . On the other hand, there are reports on α ‐glucosidase inhibitory activity of cis ‐diaryl heterocycles [36–38] .…”

Section: Introductionmentioning

confidence: 99%

Preparation of Novel 3,4,5‐Triaryl‐1,2,4‐Oxadiazole Derivatives: Molecular Docking and α‐Glucosidase assessment

Roustaei,

Saeedian Moghadam,

Faramarzi

et al. 2024

ChemistrySelect

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Diabetes mellitus (DM) has become a growing health problem, across all globe. Many factors have contributed into this issue, among them inappropriate lifestyle, unhealthy eating habits and growing spiritual/mental concerns are to be rated higher. Likewise much research needed to be diverted in progress for treatment of DM. Herein, we report synthesis and antidiabetic activity evaluation of ten novel phenolic derivatives of triaryl‐1,2,4‐oxadiazole 7 a–j. The compounds have synthesized using multistep reactions in acceptable purity and yields. Final step was done using 1,3‐dipolar cycloaddition reaction between various Schiff bases and arylnitrile oxides. 7 a–j were characterized by spectroscopic methods (1H NMR, 13C NMR, MS and IR) and their purities were confirmed using elemental analysis. All 7 a–j were evaluated for their α‐Glucosidase inhibitory activity. All compounds showed higher activity in inhibiting the enzyme, in comparison to standard, acarbose. Compounds 7 e and 7 g exerted the best activity with the IC50 value of 193.6 and 222.0 μM respectively. Furthermore, enzyme kinetic study approach was adopted to judge the effect of 7 e on enzyme inhibition. Finally, docking simulations revealed the possible mode of interactions between 7 e and 7 g and enzyme active sites. Final conclusion of results showed that oxadiazole scaffold/s are a potential antidiabetic target.

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Green Synthesis of Silver Nanoparticles Using Rhazya stricta Decne Extracts and Their Anti-Microbial and Anti-Oxidant Activities

Cited by 27 publications

References 43 publications

Investigating Novel Thiophene Carbaldehyde Based Thiazole Derivatives as Potential Hits for Diabetic Management: Synthesis, In Vitro and In Silico Approach

Investigating Novel Thiophene Carbaldehyde Based Thiazole Derivatives as Potential Hits for Diabetic Management: Synthesis, In Vitro and In Silico Approach

Bio‐fabrication of silver nanoparticles using an aqueous extract of Quercus baloot: Preparation, characterization and in vitro antimicrobial evaluation

Preparation of Novel 3,4,5‐Triaryl‐1,2,4‐Oxadiazole Derivatives: Molecular Docking and α‐Glucosidase assessment

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