Green synthesis of therapeutically active 1,3,4-oxadiazoles as antioxidants, selective COX-2 inhibitors and their in silico studies

Drug Discovery of New Anti-Inflammatory Compounds by Targeting Cyclooxygenases

“…Despite the presence of several NSAIDs, the development of new NSAIDs is attractive, owing to the diverse inflammatory conditions and the need for optimized application in relation to disease and patient conditions. The recent development of NSAIDs comprises modified methyl sulphonyl [ 17 ]; pyrimidine-5-carbonitrile hybrids [ 18 ], pyrazole derivatives [ 19 ], indanone containing spiroisoxazoline derivatives [ 20 ], triazole, and oxadiazole compounds [ 21 , 22 ]. Despite the growing repository of newly synthesized NSAIDs, the development of new compounds is strictly required due to the side effects of the currently approved NSAIDs.…”

Green Synthesis of Novel Triazolothiadiazine‐Coumarins Catalyzed by Agro Waste Extract: An Approach towards In‐Silico and In‐Vitro Anti‐Fungal Activity

“…biologically vital heterocyclic compounds and other industrially significant intermediates. [25][26][27] N-Arylsydnone acts as a novel and functional pioneer for the synthesis of varied biologically functional heterocycles viz., pyrazoles, 1,3,4-oxadiazoles, phenyl indazoles, pyrazolines, and tetrazines via 1,3-dipolar cycloaddition and addition elimination reactions. [28] Hence, we synthesized 1,2,4-triazole by using Narylsydnone that belongs to mesoionic class of compounds.…”

“…The comprehensive and influential activity of triazolothiadiazine and their derivatives has esteemed them as pharmacologically noteworthy scaffolds. Bromoacyl coumarins are being used as versatile synthons in synthetic organic chemistry, which aid to be the key model for the evolution of numerous biologically vital heterocyclic compounds and other industrially significant intermediates [25–27] …”

Chitosan‐ZnO: An Efficient and Recyclable Polymer Incorporated Hybrid Nanocatalyst to Synthesize Tetrahydrobenzo[b]pyrans and Pyrano[2,3‐d]pyrimidinones under Microwave Expedition

“…In this perspective, multicomponent reaction (MCR) has evolved as an essential strategy in organic synthesis over multistep reactions. MCRs are also beneficial for the practical constitution of chemical libraries of structurally related, medicinally important drug likecompounds [23,24] including reduction in the chemical waste, diminished reaction times and furnish higher overall chemical yields [25–28] …”

“…In this perspective, multicomponent reaction (MCR) has evolved as an essential strategy in organic synthesis over multistep reactions.MCRs are also beneficial for the practical constitution of chemical libraries of structurally related, medicinally important drug likecompounds [23,24] including reduction in the chemical waste, ChemistrySelect ChemistrySelect diminished reaction times and furnish higher overall chemical yields. [25][26][27][28] 4H-Chromene derivatives display pharmaceutical properties such as hypotensive, antimicrobial, antitumor, antileishmanial, anti-HIV and local anaesthetic agents. [29] 4H-Chromenes bearing amino and nitrile groups are more potent as anticancer agents.…”