Green synthesis of thiiranes from epoxides catalyzed by magnetically separable CuFe₂O₄/Mg(OH)₂nanocomposite in water under benign conditions

NiFe2O4@SiO2–Cu as a novel and efficient magnetically recoverable nanocatalyst for regioselective synthesis of β-thiol-1,2,3-triazoles under benign conditions

“…In continuation of our research on the successful synthesis of magnetic nanoparticles, 59–64 herein, we would like to introduce the novel recoverable NiFe 2 O 4 @SiO 2 –Cu nanocatalyst for the three-component regioselective procedure for synthesis of β-thiol-1,4-disubstituted-1,2,3 triazoles from sodium azide, thiiranes, and terminal alkynes in water at room temperature (Scheme 1).…”

“…Furthermore, in recent years, the nanostructures coated with silica, metal and metal oxides have been widely used as selective detector of biochemical substances, 54,55 easy separable catalysts in organic transformations, and smart nanomaterials utilized in the biomedical area to develop the role of biosynthesized nanoparticles for ameliorating human health through broad applications in the targeted drug delivery, controlled release drug delivery, wound dressing, tissue scaffolding, and medical implants. [56][57][58] In continuation of our research on the successful synthesis of magnetic nanoparticles, [59][60][61][62][63][64] herein, we would like to introduce the novel recoverable NiFe 2 O 4 @SiO 2 -Cu nanocatalyst for the three-component regioselective procedure for synthesis of b-thiol-1,4-disubstituted-1,2,3 triazoles from sodium azide, thiiranes, and terminal alkynes in water at room temperature (Scheme 1).…”

Organocatalytic Synthesis of Thiiranes from Alkenes

“…Except from thiocyanate salts, thiourea is also extremely common to be used as the thiolating reagent (Scheme 1F) [19] . Since 1989, when Bouda and coworkers reported the comparison between thiocyanate salts with thiourea as the thiolating agent of epoxides, [19a] a number of studies either comparing thiourea to thiocyanate salts, or studying the reaction with thiourea have appeared for the synthesis of thiiranes, utilizing either a metal catalyst, [19b–e] a heterogeneous, usually, polymetal catalyst, [19f–k] or green reaction conditions (Scheme 1F) [19l–n] . More recently, in 2016, List and coworkers described an organocatalytic synthesis of thiiranes from epoxides using a new thiolating reagent (Scheme 1G) [20a] .…”