Green synthesis of zinc oxide nanoparticles and evaluation of anti-angiogenesis, anti-inflammatory and cytotoxicity properties

Mohammad, Ghasem Rahimi Kalateh Shah; Tabrizi, Masoud Homayouni; Ardalan, Touran; Yadamani, Soheyla; Safavi, Elham

doi:10.1007/s12038-019-9845-y

Cited by 67 publications

(20 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies described pro-angiogenic [22,23,[44][45][46] as well as anti-angiogenic [47][48][49][50] properties for ZnO NPs, indicating that the corresponding characteristics are strongly dependent on the type of nanoparticles and the environmental conditions. The importance of mild reactive oxygen species generation for the formation of blood vessels is well known [51].…”

Section: Discussionmentioning

confidence: 97%

Zinc Oxide Nanoparticles Exhibit Favorable Properties to Promote Tissue Integration of Biomaterials

et al. 2021

View full text Add to dashboard Cite

Due to the demographic change, medicine faces a growing demand for tissue engineering solutions and implants. Often, satisfying tissue regeneration is difficult to achieve especially when co-morbidities hamper the healing process. As a novel strategy, we propose the incorporation of zinc oxide nanoparticles (ZnO NPs) into biomaterials to improve tissue regeneration. Due to their wide range of biocompatibility and their antibacterial properties, ZnO NPs are already discussed for different medical applications. As there are versatile possibilities of modifying their form, size, and function, they are becoming increasingly attractive for tissue engineering. In our study, in addition to antibacterial effects of ZnO NPs, we show for the first time that ZnO NPs can foster the metabolic activity of fibroblasts as well as endothelial cells, both cell types being crucial for successful implant integration. With the gelatin sponge method performed on the chicken embryo’s chorioallantoic membrane (CAM), we furthermore confirmed the high biocompatibility of ZnO NPs. In summary, we found ZnO NPs to have very favorable properties for the modification of biomaterials. Here, incorporation of ZnO NPs could help to guide the tissue reaction and promote complication-free healing.

show abstract

Section: Discussionmentioning

confidence: 97%

Zinc Oxide Nanoparticles Exhibit Favorable Properties to Promote Tissue Integration of Biomaterials

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Briefly, the aqueous H. officinalis leaf extract was added dropwise to the zinc acetate solution (0.5 M) under continues stirring at the temperature of 40°C using a Hotplate stirrer. White‐coloured precipitation was obtained; this precipitation was collected by centrifuge (3,000 g × 10 min) and was earlier characterised using FT‐IR, XRD, SEM and TEM analysis, and its result was published recently (Rahimi Kalateh Shah Mohammad, Homayouni Tabrizi, Ardalan, Yadamani, & Safavi, ).…”

Section: Methodsmentioning

confidence: 99%

Anticancer properties of green‐synthesised zinc oxide nanoparticles using Hyssopus officinalis extract on prostate carcinoma cells and its effects on testicular damage and spermatogenesis in Balb/C mice

et al. 2019

Self Cite

View full text Add to dashboard Cite

The unclear bio‐safety issue and potential risk of nanoparticles (NPs) on various organelles can be considered as a major challenge. In the present study, we have assessed the green synthesis of ZnO nanoparticles using Hyssop (Hyssopus officinalis) extract and their effects on PC3 cell line and BALB/c mice model. The cytotoxicity of the ZnO‐NPs was assessed on PC3 cell line by MTT test after characterisation. Apoptotic effect of ZnO‐NPs was determined by in vitro AO/PI staining. The histopathological assessments and determination of LH and FSH levels carried out as in vivo analysis in BALB/c adult male mice. The expression of major genes involved in spermatogenesis and sperm maturation (Adam3, Prm1, Spata19, Tnp2, Gpx5) were also analysed. The obtained result demonstrated that the IC50 for PC3 cell line treated with green‐synthesised ZnO‐NPs during 24 and 48 hr was reported 8.07 and 5 µg/ml respectively. Meanwhile, the induced apoptosis was recorded 26.6% ± 0.05, 44% ± 0.12 and 80% ± 0.07 of PC3 cells. The results of gene expression analysis revealed that the increase in the concentration of ZnO‐NPs significantly (p < .05) down‐regulated the Adam3, Prm1, Spata‐19, Tnp2 and Gpx5 genes. The overall results of this research elucidated that ZnO‐NPs impaired spermatogenesis, sperm maturation process and sperm motility.

show abstract

“…The diagnosis of bacterial infections has met with several challenges and is concerning, especially with the emergence of bacterial resistance to traditional antibiotics as a result of unchecked and unprescribed antibiotic usage . Thus, the discovery of new and effective bactericidal agents is essential in clinical practice.…”

Section: Application Of Plant Extract Based Nanoparticle Synthesismentioning

confidence: 99%

Green Synthesis of Nanoparticles and Their Biomedical Applications: A Review

Shreyash

Bajpai

Khan

et al. 2021

ACS Appl. Nano Mater.

138

View full text Add to dashboard Cite

In the arena of material sciences, one of the burning topics for research has been biogenically synthesizing nanoparticles (NPs) from plant derivatives and studying their applicability to be used as sustainable catalysts. The contemporary work happening on nanocatalysts focuses on the scope of application of green catalysts. For devising a technology that is ecofriendly as well as rapid, it seems a very viable option to biogenically synthesize NPs from plants. The potential that plants have in synthesizing these NPs has been mostly an unexplored venture, and the massive plant diversity is the reason for this is the lack of exploration. The NPs have antioxidant, antibacterial, and antimicrobial characteristics, which make them suitable candidates for application in different biomedical applications. This review begins with a discussion about the different natural products that are used for NP synthesis and goes on to discuss the factors that affect the synthesis. The authors have aimed to provide detailed information about green NPs and their applications in different biomedical areas. Existing literature on NP-based biomedical applications focuses more on synthetic NPs, and we hope that this review will help the readers to formulate a fresh perspective by concentrating their interests toward naturally synthesized NPs and their applications.

show abstract

Green synthesis of zinc oxide nanoparticles and evaluation of anti-angiogenesis, anti-inflammatory and cytotoxicity properties

Cited by 67 publications

References 20 publications

Zinc Oxide Nanoparticles Exhibit Favorable Properties to Promote Tissue Integration of Biomaterials

Zinc Oxide Nanoparticles Exhibit Favorable Properties to Promote Tissue Integration of Biomaterials

Anticancer properties of green‐synthesised zinc oxide nanoparticles using Hyssopus officinalis extract on prostate carcinoma cells and its effects on testicular damage and spermatogenesis in Balb/C mice

Green Synthesis of Nanoparticles and Their Biomedical Applications: A Review

Contact Info

Product

Resources

About