Green synthesised copper and copper oxide based nanomaterials using plant extracts and their application in antimicrobial activity: Review

Bhavyasree, P.G.; Xavier, T.S.

doi:10.1016/j.crgsc.2021.100249

Cited by 59 publications

(28 citation statements)

References 154 publications

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“…CuO-and Cu-based nanoparticles have shown exert a strong biological activity (e. g., antibacterial, antifungal, antiviral and anticancer) towards a wide group of pathogenic microorganisms and viruses and this has been already displayed in several studies [27][28][29][30][31][32] . This characteristic makes CuO commercially applicable in paints, fabrics, agriculture and in production of medical devices used to prevent potential infections 33 .…”

Section: Discussionmentioning

confidence: 99%

Biological mechanism of cell oxidative stress and death during short-term exposure to nano CuO

Moschini

Colombo

Chirico

et al. 2023

Sci Rep

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It is well known that copper oxide nanoparticles (CuO NPs) are heavily toxic on in vitro systems. In human alveolar epithelial cells, the mechanism of toxicity is mostly related to oxidative insults, coming from intracellularly dissolved copper ions, finally leading to apoptotic or autophagic cell death. Our hypothesis is based on possible early oxidative events coming from specific NP surface reactivity able to undermine the cell integrity and to drive cell to death, independently from Lysosomal-Enhanced Trojan Horse mechanism. Two types of CuO NPs, with different oxidative potential, were selected and tested on A549 cells for 1 h and 3 h at 10, 25, 50 and 100 µg/ml. Cells were then analyzed for viability and oxidative change of the proteome. Oxidative by-products were localized by immunocytochemistry and cell-NP interactions characterized by confocal and electron microscopy techniques. The results show that CuO NPs induced oxidative changes soon after 1 h exposure as revealed by the increase in protein carbonylation and reduced-protein-thiol oxidation. In parallel, cell viability significantly decreased, as shown by MTT assay. Such effects were higher for CuO NPs with more crystalline defects and with higher ROS production than for fully crystalline NPs. At these exposure times, although NPs efficiently interacted with cell surface and were taken up by small endocytic vesicles, no ion dissolution was visible inside the lysosomal compartment and no effects were produced by extracellularly dissolved copper ions. In conclusion, a specific NP surface-dependent oxidative cell injury was demonstrated. More detailed studies are required to understand which targets precociously react with CuO NPs, but these results introduce new paradigms for the toxicity of the metal-based NPs, beyond the Lysosomal-Enhanced Trojan horse-related mechanism, and open-up new opportunities to investigate the interactions and effects at the bio-interface for designing safer as well as more effective CuO-based biocides.

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Section: Discussionmentioning

confidence: 99%

Biological mechanism of cell oxidative stress and death during short-term exposure to nano CuO

Moschini

Colombo

Chirico

et al. 2023

Sci Rep

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“…11,12 Recently, CuO NPs have been largely prepared for various applications in elds ranging from semi-conductors to biomedical. For the latter, many studies involving CuO NPs have been carried out on anti-bacterial, 13,14 anti-biolm, 14 anti-cancer, 15 anti-microbial, 16 and anti-fungal 17 aspects. Among these studies, biolms were explored several a Laboratory of Materials for Energy and Environment, and Modeling (LMEEM), Faculty of Sciences, University of Sfax, B.P: 1171, 3038, Tunisia.…”

Section: Introductionmentioning

confidence: 99%

Non-doped and transition metal-doped CuO nano-powders: structure-physical properties and anti-adhesion activity relationship

et al. 2022

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“…However, in the FT-IR spectrum related to the biosynthesized CuNPs, due to coordinating copper oxide nanoparticles, the peak related to O-H stretching vibrations appeared at 3401 cm -1 and the peak related to C=O at 1552 cm -1 with a much lower intensity (Figure 3, b). It is suggested that these functional groups play a synergistic role in the capping and reduction of NPs [25,26]. Also, the peak appearing in the region of 532 cm -1 is related to CuO bond vibrations [37].…”

Section: Ft-ir Analysismentioning

confidence: 99%

Green synthesis of copper nanoparticles using Artemisia annua aqueous extract and its characterization, antioxidant and burn wound healing activities

Karimi

Mardani

Kaboutari

et al. 2023

Preprint

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the current study reports a green method for synthesizing copper nanoparticles (CuNPs) using aqueous extract of Artemisia annua in a simple, and eco-friendly manner. The green synthesized CuNPs were characterized using UV–Vis, FT-IR spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM) and Energy Dispersive X-ray analysis (EDX). The UV-Vis spectroscopy showed maximum absorption at 250 nm, and the average diameter of the synthesized NPs was found to be 35 nm. FTIR showed the presence of functional groups in bioactive constituents responsible for reducing Cu+ ions. The antioxidant activity of the synthesized NPs was evaluated by DPPH assay, and at 100 µg/ml green synthesized CuNPs, the highest antioxidant activity was obtained, which was 67 % and an IC50 value of 73.48 µg/ml. In the in vivo experiment, after inducing 2nd degree burn wounds, the rats were randomly divided into five group including the untreated control, treatment with eucerin basal ointment, treatment with 0.2 % CuNP ointment, treatment with 0.2 % CuNP-loaded ointment, and treatment with 5 % Artemisia annua extract twice a day for 21 days. Application of biosynthesized CuNPs ointment significantly improved the healing percentage and hydroxyproline content compared to the control. Additionally, histopathology studies showed significant progress in re-epithelization, collagen fiber deposition, and angiogenesis in the biosynthesized CuNPs in comparison to the control. The greenly synthesized CuNPs had enhanced antioxidant, and wound healing properties and, therefore, could be considered as a promising candidate in the biomedical field.

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Green synthesised copper and copper oxide based nanomaterials using plant extracts and their application in antimicrobial activity: Review

Cited by 59 publications

References 154 publications

Biological mechanism of cell oxidative stress and death during short-term exposure to nano CuO

Biological mechanism of cell oxidative stress and death during short-term exposure to nano CuO

Non-doped and transition metal-doped CuO nano-powders: structure-physical properties and anti-adhesion activity relationship

Green synthesis of copper nanoparticles using Artemisia annua aqueous extract and its characterization, antioxidant and burn wound healing activities

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