“…5b). The obtained results are consistent with other studies 19,50 . Polyphenol constituents as specialized metabolites of plants possess redox properties and many therapeutic bene cial effects that interact with AgNPS as reducing and capping agents 51 .…”
Section: Phenolics Contentsupporting
confidence: 94%
“…It has been indicated that the spherical structure of AgNPs is a reason for creating unremarkable Raman peaks 20 . SERS spectroscopy has been rarely reported for biosynthesized AgNPs 19,45 . Indeed, the SERS experiments represented that the feature of (phyto)-functionalization of AgNPs permits other molecules to approach the NPs surface (a distance of a few nm) to "feel" the plasmon eld of the NPs and this information is very important for other applications of the biosynthesized NPs 45 .…”
Section: Ftir and Raman Spectroscopy Analysismentioning
confidence: 99%
“…18 , Scutellaria multicaulis Boiss. 19 , Heracleum persicum Desf. 20 , Origanum vulgare L. 21 , and Salvia spinosa L. 9 as well as their biological applications have been previously reported.…”
Green synthesized nanoparticles (GSNPs) display fascinating properties compared to physical and chemical synthesized ones. GSNPs are currently used in numerous applications such as food packaging, surface coating agents, environmental remediation, antimicrobial, and medicine. In the present study, the aqueous leaf extract of Perilla frutescens L. having suitable capping, reducing, and stabilizing compounds was used for green synthesis of silver nanoparticles (Pf-AgNPs). The bioreductant capacity of aqueous leaf extract of P. frutescens for Pf-AgNPs was determined by different confirmatory techniques including UV-Visible spectroscopy, XRD, FESEM, EDX, zeta potential, DLS, SERS, and FTIR analysis. The results exhibited that Pf-AgNPs had optimal size (< 61nm), shape (spherical), and stability (-18.1 mV). The antioxidant activity of Pf-AgNPs with both DPPH and FRAP assays was significantly higher compared to P. frutescens extract. Furthermore, Pf-AgNPs had high antimicrobial activity against Escherichia coli and Staphylococcus aureus (MIC= 0.78 mg/mL), and Candida albicans (MIC= 8 mg/mL) while the plant extract showed low antimicrobial activity against both bacterial strains and the fungus tested. Pf-AgNPs and P. frutescens extract also exhibited moderate toxicity on MCF-7 cancer cells with IC50 values of 346.2 and 467.4 µg/mL, respectively. The results provide insights into using the biosynthesized Pf-AgNPs as an eco-friendly material for a wide range of biomedical applications.
“…5b). The obtained results are consistent with other studies 19,50 . Polyphenol constituents as specialized metabolites of plants possess redox properties and many therapeutic bene cial effects that interact with AgNPS as reducing and capping agents 51 .…”
Section: Phenolics Contentsupporting
confidence: 94%
“…It has been indicated that the spherical structure of AgNPs is a reason for creating unremarkable Raman peaks 20 . SERS spectroscopy has been rarely reported for biosynthesized AgNPs 19,45 . Indeed, the SERS experiments represented that the feature of (phyto)-functionalization of AgNPs permits other molecules to approach the NPs surface (a distance of a few nm) to "feel" the plasmon eld of the NPs and this information is very important for other applications of the biosynthesized NPs 45 .…”
Section: Ftir and Raman Spectroscopy Analysismentioning
confidence: 99%
“…18 , Scutellaria multicaulis Boiss. 19 , Heracleum persicum Desf. 20 , Origanum vulgare L. 21 , and Salvia spinosa L. 9 as well as their biological applications have been previously reported.…”
Green synthesized nanoparticles (GSNPs) display fascinating properties compared to physical and chemical synthesized ones. GSNPs are currently used in numerous applications such as food packaging, surface coating agents, environmental remediation, antimicrobial, and medicine. In the present study, the aqueous leaf extract of Perilla frutescens L. having suitable capping, reducing, and stabilizing compounds was used for green synthesis of silver nanoparticles (Pf-AgNPs). The bioreductant capacity of aqueous leaf extract of P. frutescens for Pf-AgNPs was determined by different confirmatory techniques including UV-Visible spectroscopy, XRD, FESEM, EDX, zeta potential, DLS, SERS, and FTIR analysis. The results exhibited that Pf-AgNPs had optimal size (< 61nm), shape (spherical), and stability (-18.1 mV). The antioxidant activity of Pf-AgNPs with both DPPH and FRAP assays was significantly higher compared to P. frutescens extract. Furthermore, Pf-AgNPs had high antimicrobial activity against Escherichia coli and Staphylococcus aureus (MIC= 0.78 mg/mL), and Candida albicans (MIC= 8 mg/mL) while the plant extract showed low antimicrobial activity against both bacterial strains and the fungus tested. Pf-AgNPs and P. frutescens extract also exhibited moderate toxicity on MCF-7 cancer cells with IC50 values of 346.2 and 467.4 µg/mL, respectively. The results provide insights into using the biosynthesized Pf-AgNPs as an eco-friendly material for a wide range of biomedical applications.
“…The unwanted peaks in the spectrum indicated the presence of various bioactive reducing agents and capping compounds accumulated on the surface of Ag NPs. The reducing agents of plant extract compounds were responsible for the synthesis of Ag NPs [ 29 ]. Fig.…”
Bio-fabrication has become a safe approach for silver nanoparticles (Ag NPs). The plant-mediated biosynthesized Ag NPs have emerged as a potential substitute for conventional chemical formation. The biosynthesized Ag NPs were analyzed in terms of crystalline nature, morphology, chemical composition, particle size, stability, size, and shape of the particles. The XRD, FTIR, and TEM analysis indicate the presence of the bioactive secondary metabolites compounds. The bamboo-mediated Ag NPs demonstrated a notable antibacterial efficacy against Gram-positive and Gram-negative pathogenic microorganisms and showed significant antioxidant activity against DPPH free radicals. The degradation of methylene blue at various intervals under solar light irradiation was used to evaluate the photocatalytic performance of Ag NPs. Further, Ag NPs conveyed potent anticancer activity against MCF-7 cell lines with a significant value IC
50
. The bamboo leaves-mediated Ag NPs synthesized Ag NPs signified strong antibacterial, antioxidant, and anticancer activity; hence, it can be used in various biomedical applications and face mask coating to prevent the coronavirus after successful clinical trials in research laboratories.
Essential oils have many important biological properties, including antibacterial and antibiofilm activities. These unique properties make, essential oils good alternatives to synthetic chemical drugs, which have many side effects. In this study, we aimed to determine the chemical composition and biological activity of the essential oil obtained from Scutellaria brevibracteata subsp. brevibracteata. Specifically, its antibiofilm activity against Pseudomonas aeruginosa PAO1 and Staphylococcus aureus ATCC 29213 biofilms using XTT assay. Cytotoxic and apoptotic properties of the essential oil were investigated in human lung cancer cells (A540 and H1299) using MTT assay, Annexin V‐FITC and propidium iodide staining and q‐PCR. Thirty‐two different compounds were identified from the essential oil, of which elemol (20.42%), γ‐eudesmol (20.12%) and β‐eudesmol (14.85%) were the main components. The essential oil was more effective against P. aeruginosa PAO1 biofilm (79%) than S. aureus ATCC 29213 biofilm (27%). The specific activity of the essential oil against P. aeruginosa biofilm may be related to its high terpene contents. In addition, the essential oil showed high cytotoxic activity towards A549 (IC50 9.09 µg/ml) and H1299 (IC50 55.04 µg/ml) cell lines, inducing apoptosis in these cancer cells. These results demonstrate the antibiofilm and anticancer activities of S. brevibracteata subsp. brevibracteata essential oil.
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