Green synthesized MgO nanoparticles infer biocompatibility by reducing in vivo molecular nanotoxicity in embryonic zebrafish through arginine interaction elicited apoptosis

Verma, Suresh K.; Kumari, Nisha; Panda, Pritam Kumar; Patel, Paritosh; Kumari, Puja; Mallick, M. A.; Sarkar, Biplab; Das, Biswadeep

doi:10.1016/j.scitotenv.2020.136521

Cited by 77 publications

(38 citation statements)

References 49 publications

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“…The treatment of MgONPs of MCF-7 cells caused morphological alteration and chromatin condensation in the nucleus, illustrating the apoptotic effect of MgONPs depend on the production of ROS, which resulted in oxidative stress mediated cell death in MCF-7 cells (Fig 10C). The intracellular ROS level enhanced by MgONPs disrupted the MMP and caused activation of the intrinsic pathway of apoptosis leading to cell death [65].…”

Section: Plos Onementioning

confidence: 99%

Biogenic green synthesis of MgO nanoparticles using Saussurea costus biomasses for a comprehensive detection of their antimicrobial, cytotoxicity against MCF-7 breast cancer cells and photocatalysis potentials

et al. 2020

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Distinct morphological MgO nanoparticles (MgONPs) were synthesized using biomasses of Saussurea costus roots. The biomass of two varieties of Saussurea costus (Qustal hindi and Qustal bahri) were used in the green synthesis of MgONPs. The physical and chemical features of nanoparticles were confirmed by spectroscopic and microscopic techniques. The surface morphology of the obtained nanoparticles was detected at different magnifications by SEM and TEM microscopy and the size of nanoparticles were found to be 30 and 34 nm for Qustal hindi and Qustal bahri, respectively. The antimicrobial activity of the prepared MgONPs was screened against six pathogenic strains. The synthesized nanoparticles by Qustal bahri biomass exerted significant inhibition zones 15, 16, 18, 17, 14, and 10 mm against E. coli, P. aeruginosa, C. tropicalis and C. glabrata, S. aureus and B. subtilis as compared to those from Qustal hindi 12, 8 and 17 mm against B. subtilis, E. coli and C. tropicalis, respectively. MgONPs showed a potential cytotoxicity effect against MCF-7 breast cancer cell lines. Cellular investigations of MgONPs revealed that the prepared nanoparticles by Qustal bahri exhibited high cytotoxicity against MCF-7 cancer cell lines. IC 50 values in MCF-7 cells were found to be 67.3% and 52.1% for MgONPs of Saussurea costus biomasses, respectively. Also, the photocatalytic activity of MgONPs of each Saussurea costus variety was comparatively studied. They exhibited an enhanced photocatalytic degradation of methylene blue after UV irradiation for 1 h as 92% and 59% for those prepared by Qustal bahri and Qustal hindi, respectively. Outcome of results revealed that the biosynthesized MgONPs showed promising biomedical potentials.

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Section: Plos Onementioning

confidence: 99%

Biogenic green synthesis of MgO nanoparticles using Saussurea costus biomasses for a comprehensive detection of their antimicrobial, cytotoxicity against MCF-7 breast cancer cells and photocatalysis potentials

et al. 2020

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“…Various metal oxides and nano-ferrites are of great interest as they exhibit varying morphologies and show significant antibacterial activity over a wide range of micro-organisms [ 32 , 44 ]. Metal oxides such as ZnO [ 45 ], TiO 2 [ 18 , 19 , 46 , 47 ], MgO [ 48 , 49 ] and CuO [ 50 ] have high reactivity, enhanced bio-availability and bioactivity which possess great concern in food technology. Similarly, metal ferrites such as zinc ferrite, copper ferrite, cobalt ferrite, nickel ferrite etc., have unique magnetic properties, excellent chemical stability, large lattice constant, large antibacterial properties are characterized by strong antibacterial properties [ 51 , 52 ].…”

Section: The Demand For Nanoparticles In Life Sciencesmentioning

confidence: 99%

“…The synthesis of Azadirachta indica green leaf extract is shown in Fig. 5 , it is also environmentally friendly and economically favorable as compared to the different chemical processes [ 49 ]. Calotropis gigantea was used in synthesis of MgO nanoparticles, which is an environmentally friendly approach, and its toxicity was evaluated in zebra-fish [ 49 ].…”

Section: Various Techniques For Nanoparticle Synthesismentioning

confidence: 99%

“…5 , it is also environmentally friendly and economically favorable as compared to the different chemical processes [ 49 ]. Calotropis gigantea was used in synthesis of MgO nanoparticles, which is an environmentally friendly approach, and its toxicity was evaluated in zebra-fish [ 49 ]. Bhuyan et al , in 2015 synthesized ZnO nanoparticles from neem ( Azardirachta indica ) [ 89 ].…”

Section: Various Techniques For Nanoparticle Synthesismentioning

confidence: 99%

“…Metabolites (discussed above) play a key role in the overall formation of the eco-friendly nanoparticles. Metal oxide nanoparticles such as ZnO [ 7 , 8 , 27 , 34 , 53 , 63 , 89 ], MgO [ 48 , 49 ], CuO [ 50 ], TiO 2 [ 18 , 19 , 46 , 47 ], Graphene [ 4 ], etc., have a great application in food system due to its great antimicrobial activity against pathogenic microorganisms. Nanoparticles can be synthesized from a wide variety of biological entities such as actinomycetes, algae, bacteria, fungus, plants, viruses, and yeast.…”

Section: Various Techniques For Nanoparticle Synthesismentioning

confidence: 99%

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Nanotechnology and its challenges in the food sector: a review

Kumar

Mahajan

Kaur

et al. 2020

Materials Today Chemistry

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Antibacterial activity of nanoparticles has received significant attention worldwide because of their great physical and chemical stability, excellent magnetic properties, and large lattice constant values. These properties are predominate in the food science for enhancing the overall quality, shelf life, taste, flavor, process-ability, etc., of the food. Nanoparticles exhibit attractive antibacterial activity due to their increased specific surface area leading to enhanced surface reactivity. When nanoparticles are suspended in the biological culture, they encounter various biological interfaces, resulting from the presence of cellular moieties like DNA, proteins, lipids, polysaccharides, etc., which helps antibacterial properties in many ways. This paper reviews different methods used for the synthesis of nanoparticles but is specially focusing on the green synthesis methods owing to its non-toxic nature towards the environment. This review highlights their antibacterial application mainly in the food sector in the form of food-nanosensors, food-packaging, and food-additives. The possible mechanism of nanoparticles for their antibacterial behavior underlying the interaction of nano-particles with bacteria, (i) excessive ROS generation including hydrogen peroxide (H 2 O 2 ), OH − (hydroxyl radicals), and O − 2 2 (peroxide); and (ii) precipitation of nano-particles on the bacterial exterior; which, disrupts the cellular activities, resulting in membranes disturbance. All these phenomena results in the inhibition of bacterial growth. Along with this, their current application and future perspectives in the food sector are also discussed. Nanoparticles help in destroying not only pathogens but also deadly fungi and viruses. Most importantly it is required to focus more on the crop processing and its containment to stop the post-harvesting loss. So, nanoparticles can act as a smart weapon towards the sustainable move.

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Plant extract‐based synthesis of metallic nanomaterials, their applications, and safety concerns

Ullah

Lim

2022

Biotech & Bioengineering

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Nanotechnology has attracted the attention of researchers from different scientific fields because of the escalated properties of nanomaterials (NMs) compared with the properties of macromolecules. NMs can be prepared through different approaches involving physical and chemical methods. The development of NMs through plantbased green chemistry approaches is more advantageous than other methods from the perspectives of environmental safety, animal, and human health. The biomolecules and metabolites of plants act as reducing and capping agents for the synthesis of metallic green NMs. Plant-based synthesis is a preferred approach as it is not only cost-effective, easy, safe, clean, and eco-friendly but also provides pure NMs in high yield. Since NMs have antimicrobial and antioxidant potential, green NMs synthesized from plants can be used for a variety of biomedical and environmental remediation applications. Past studies have focused mainly on the overall biogenic synthesis of individual or combinations of metallic NMs and their oxides from different biological sources, including microorganisms and biomolecules.Moreover, from the viewpoint of biomedical applications, the literature is mainly focusing on synthetic NMs. Herein, we discuss the extraction of green molecules and recent developments in the synthesis of different plant-based metallic NMs, including silver, gold, platinum, palladium, copper, zinc, iron, and carbon. Apart from the biomedical applications of metallic NMs, including antimicrobial, anticancer, diagnostic, drug delivery, tissue engineering, and regenerative medicine applications, their environmental remediation potential is also discussed. Furthermore, safety concerns and safety regulations pertaining to green NMs are also discussed.

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Green synthesized MgO nanoparticles infer biocompatibility by reducing in vivo molecular nanotoxicity in embryonic zebrafish through arginine interaction elicited apoptosis

Cited by 77 publications

References 49 publications

Biogenic green synthesis of MgO nanoparticles using Saussurea costus biomasses for a comprehensive detection of their antimicrobial, cytotoxicity against MCF-7 breast cancer cells and photocatalysis potentials

Biogenic green synthesis of MgO nanoparticles using Saussurea costus biomasses for a comprehensive detection of their antimicrobial, cytotoxicity against MCF-7 breast cancer cells and photocatalysis potentials

Nanotechnology and its challenges in the food sector: a review

Plant extract‐based synthesis of metallic nanomaterials, their applications, and safety concerns

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