Green Synthesized Zinc Oxide Nanoparticles Attenuate Acrylamide-Induced Cardiac Injury via Controlling Endoplasmic Reticulum Stress–Associated Apoptosis Through ATF3/CHOP/BCL2 Signaling in Rats

Alosaimi, Manal; Abd-Elhakim, Yasmina M.; Mohamed, Amany Abdel-Rahman; Metwally, Mohamed M. M.; Khamis, Tarek; Alansari, Wafa S.; Eskandrani, Areej A.; Essawi, Walaa M.; Awad, Marwa M.; El-Shaer, Rehab A. A.; Ibrahim, Sarah; Nassan, Mohamed A.; Metwally, Aya Sh.

doi:10.1007/s12011-023-03855-1

Cited by 4 publications

(1 citation statement)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3–7 Toxicological data from in vivo and in vitro showed that AA caused multiple toxicities, including neurotoxicity, reproductive toxicity, carcinogenicity, genotoxicity, hepatotoxicity, nephrotoxicity, and cardiac toxicity. 8–12 Recently, our study confirmed that short term high-dose AA (30 mg per kg bw) can induce glucose metabolism disorders (GMDs). 13,14 However, the effects of prolonged low-dose AA exposure on host glucose homeostasis are still poorly understood.…”

Section: Introductionsupporting

confidence: 57%

Lactobacillus reuteri JCM 1112 ameliorates chronic acrylamide-induced glucose metabolism disorder via the bile acid–TGR5–GLP-1 axis and modulates intestinal oxidative stress in mice

Yue,

Zhao,

Guo

et al. 2024

Food Funct.

View full text Add to dashboard Cite

show abstract

Section: Introductionsupporting

confidence: 57%

Lactobacillus reuteri JCM 1112 ameliorates chronic acrylamide-induced glucose metabolism disorder via the bile acid–TGR5–GLP-1 axis and modulates intestinal oxidative stress in mice

Yue,

Zhao,

Guo

et al. 2024

Food Funct.

View full text Add to dashboard Cite

show abstract

Mitigating effect of gallic acid on zinc oxide nanoparticles and arsenic trioxide-induced spermatogenesis suppression, testicular injury, hormonal imbalance, and immunohistochemical changes in rats

Behairy,

Hashem,

Abo-EL-Sooud

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

The current study compared the effects of incorporated exposure to arsenic trioxide (As) and zinc oxide nanoparticles (ZnONPs) on male reproductive hormones, oxidative stress, and inflammatory biomarkers in adult rats to each metal alone. A defensive trial with gallic acid (GA) has also been studied. A total of 60 adult male Sprague Dawley rats were categorized into six groups: control, GA (20 mg/kg), ZnONPs (100 mg/kg), As (8 mg/kg), ZnONPs with As, and GA concurrently with ZnONPs and As at the same previous doses. The regimens were applied for 60 days in sequence. Current findings showed significant weight loss in all study groups, with testicular weights significantly decreased in the As and combined groups. Testosterone, follicular stimulating hormone, and luteinizing hormone serum levels were also considerably reduced, while serum levels of estradiol increased. Inducible nitric oxide synthase (iNOS) immunoexpression was significantly upregulated while proliferating cell nuclear antigen (PCNA) was downregulated. Moreover, there was a significant elevation of testicular malondialdehyde, reduction of testicular superoxide dismutase, and glutathione peroxidase with disruptive testes, prostate glands, and seminal vesicle alterations in all experimental groups with marked changes in the combined group. Additionally, the present results revealed the protective effects of GA on ZnONPs and As adverse alterations in rats. GA enhanced sperm picture, oxidant status, and hormonal profile. Also, it modulates iNOS and PCNA immunoexpression and recovers the histoarchitecture of the testes, prostate glands, and seminal vesicles. Ultimately, GA may be a promising safeguarding agent against ZnONPs and As-induced disturbances to reproductive parameters.

show abstract

Tri-iso-butyl phosphate (TiBP) exposure induces neurotoxicity by triggering oxidative stress accompanied by neurotransmitter system disruptions and apoptosis in zebrafish larvae

Luo,

Zhang,

Wang

et al. 2024

Environmental Pollution

View full text Add to dashboard Cite

Green Synthesized Zinc Oxide Nanoparticles Attenuate Acrylamide-Induced Cardiac Injury via Controlling Endoplasmic Reticulum Stress–Associated Apoptosis Through ATF3/CHOP/BCL2 Signaling in Rats

Cited by 4 publications

References 86 publications

Lactobacillus reuteri JCM 1112 ameliorates chronic acrylamide-induced glucose metabolism disorder via the bile acid–TGR5–GLP-1 axis and modulates intestinal oxidative stress in mice

Lactobacillus reuteri JCM 1112 ameliorates chronic acrylamide-induced glucose metabolism disorder via the bile acid–TGR5–GLP-1 axis and modulates intestinal oxidative stress in mice

Mitigating effect of gallic acid on zinc oxide nanoparticles and arsenic trioxide-induced spermatogenesis suppression, testicular injury, hormonal imbalance, and immunohistochemical changes in rats

Tri-iso-butyl phosphate (TiBP) exposure induces neurotoxicity by triggering oxidative stress accompanied by neurotransmitter system disruptions and apoptosis in zebrafish larvae

Contact Info

Product

Resources

About