Green Synthetic Approach for Photo-Cross-Linkable Methacryloyl Hyaluronic Acid with a Tailored Substitution Degree

Sigen, A; Zeng, Ming; Johnson, Melissa; Creagh-Flynn, Jack; Xu, Qian; Tai, Hongyun; Wang, Wenxian

doi:10.1021/acs.biomac.0c00196

Cited by 17 publications

(5 citation statements)

References 23 publications

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“…Characterization of PDA NPs@HAMA Nuclear magnetic resonance spectroscopy (1H NMR) results revealed that the emerging signals at 5.6 and 6.2 ppm in HAMA, belonging to the protons of -CH=CH2, which confirmed that methacrylic acid was successfully connected to the skeleton of HA (Figure 1a). 30 Compared with HA, the stretching vibration band of C=O in HAMA was divided into two peaks, demonstrating the presence of anhydride (Figure 1b). The enhanced C-O-C stretching vibration also indicated that the ester bond was formed after modification, further verifying the conjugation of the carbon-carbon double bond in HAMA that endowed the cross-linkable and photocurable functions.…”

Section: Resultsmentioning

confidence: 99%

Photothermal Treatment of Polydopamine Nanoparticles@Hyaluronic Acid Methacryloyl Hydrogel Against Peripheral Nerve Adhesion in a Rat Model of Sciatic Nerve

Zhan¹,

Zhou²,

Chen³

et al. 2023

IJN

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Purpose Peripheral nerve adhesion occurs following injury and surgery. Functional impairment leading by peripheral nerve adhesion remains challenging for surgeons. Local tissue overexpression of heat shock protein (HSP) 72 can reduce the occurrence of adhesion. This study aims to develop a photothermal material polydopamine nanoparticles@Hyaluronic acid methacryloyl hydrogel (PDA NPs@HAMA) and evaluate their efficacy for preventing peripheral nerve adhesion in a rat sciatic nerve adhesion model. Materials and Methods PDA NPs@HAMA was prepared and characterized. The safety of PDA NPs@HAMA was evaluated. Seventy-two rats were randomly assigned to one of the following four groups: the control group; the hyaluronic acid (HA) group; the polydopamine nanoparticles (PDA) group and the PDA NPs@HAMA group (n = 18 per group). Six weeks after surgery, the scar formation was evaluated by adhesion scores and biomechanical and histological examinations. Nerve function was assessed with electrophysiological examination, sensorimotor analysis and gastrocnemius muscle weight measurements. Results There were significant differences in the score on nerve adhesion between the groups (p < 0.001). Multiple comparisons indicated that the score was significantly lower in the PDA NPs@HAMA group (95% CI: 0.83, 1.42) compared with the control group (95% CI: 1.86, 2.64; p = 0.001). Motor nerve conduction velocity and muscle compound potential of the PDA NPs@HAMA group were higher than the control group’s. According to immunohistochemical analysis, the PDA NPs@HAMA group expressed more HSP72, less α-smooth muscle actin (α-SMA), and had fewer inflammatory reactions than the control group. Conclusion In this study, a new type of photo-cured material with a photothermic effect was designed and synthesized-PDA NPs@HAMA. The photothermic effect of PDA NPs@HAMA protected the nerve from adhesion to preserve the nerve function in the rat sciatic nerve adhesion model. This effectively prevented adhesion-related damage.

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Section: Resultsmentioning

confidence: 99%

Photothermal Treatment of Polydopamine Nanoparticles@Hyaluronic Acid Methacryloyl Hydrogel Against Peripheral Nerve Adhesion in a Rat Model of Sciatic Nerve

Zhan¹,

Zhou²,

Chen³

et al. 2023

IJN

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“…Methacryloyl hydrazide was synthesized following a reported procedure, which was slightly modified . Methacrylic anhydride (10.35 g, 0.067 mol) was dissolved in chloroform (40 mL) and then added dropwise to hydrazine monohydrate in a 50 mL 2-necked round bottom flask (14 mL, 0.288 mol) at 0 °C for 30 min.…”

Section: Methodsmentioning

confidence: 99%

Release of Fragrances from Polymer Coatings Triggered by Contact with Sweat

Phoungtawee

Jaroonwatana

Crespy

2023

ACS Appl. Polym. Mater.

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Fragrances are active compounds that suffer from the fact that fragrances are usually quickly volatile and hence display a limited use in daily life applications. To overcome this problem, the fragrances benzaldehyde and heptanal are conjugated to a monomer via a hydrazone linkage. The functional monomers are then reacted with a urethane acrylate by photopolymerization to yield thin polymer coatings. The release of fragrances from the coatings was measured by UV−visible spectroscopy and headspace gas chromatography−mass spectrometry techniques, showing sustained release in artificial sweat due to the slow kinetics of the hydrolysis of the hydrazone linkage. This simple strategy can be applied for the rapid preparation of coatings on contact with wet human skin in labeling applications.

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“…In the realm of tissue engineering, hyaluronic acid has been increasingly utilized as a scaffolding biopolymer. Islet cells that were encapsulated in hyaluronic acid and alginate matrices have reportedly shown high viability and insulin secretion [160]. Additionally, hyaluronic acid-alginate hybrid microcapsules have been demonstrated by Cañibano-Hernández et al [158] to decrease apoptosis and boost β-cell survival.…”

Section: Hyaluronic Acidmentioning

confidence: 99%

Recent advances in the development of bioartificial pancreas using 3D bioprinting for the treatment of type 1 diabetes: a review

Ghosh,

Sanyal,

Mallick

2023

Exploration of Medicine

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Type 1 diabetes is a chronic condition that results from the destruction of insulin-producing β-cells in the pancreas. Current treatments for type 1 diabetes, such as insulin therapy and pancreatic islet transplantation, have several limitations and, hence not quite effective in the long run. As current therapy methods fail to slow disease development, novel strategies such as the development of a bioartificial pancreas are being seriously considered. Over the last decade, research has focused on tissue engineering, which aids in the design of biological alternatives for the repair and replacement of non-functional or damaged organs. Three dimensional (3D) bioprinting technology which employs 3D printing technology to generate 3D tissue-like structures from biomaterials and cells, offers a promising solution for the treatment of type 1 diabetes by providing the ability to generate functional endocrine pancreatic tissue. Bioprinted structures are therefore an important aspect of tissue engineering because they have been found to replicate the native extracellular matrix, promoting cell survival and proliferation. In this review, recent developments in 3D bioprinting of endocrine pancreas for the treatment of type 1 diabetes particularly focussing on the choice of cells, biomaterials, growth factors, and essential considerations have been discussed in detail. Additionally, the key challenges and perspectives towards recapitulation of the pancreatic function of the pancreatic organ engineering technologies have also been discussed.

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Green Synthetic Approach for Photo-Cross-Linkable Methacryloyl Hyaluronic Acid with a Tailored Substitution Degree

Cited by 17 publications

References 23 publications

Photothermal Treatment of Polydopamine Nanoparticles@Hyaluronic Acid Methacryloyl Hydrogel Against Peripheral Nerve Adhesion in a Rat Model of Sciatic Nerve

Photothermal Treatment of Polydopamine Nanoparticles@Hyaluronic Acid Methacryloyl Hydrogel Against Peripheral Nerve Adhesion in a Rat Model of Sciatic Nerve

Release of Fragrances from Polymer Coatings Triggered by Contact with Sweat

Recent advances in the development of bioartificial pancreas using 3D bioprinting for the treatment of type 1 diabetes: a review

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