Green synthetic strategies toward thiazoles: a sustainable approach

Access to thiazoline and spiro[indoline-3,3′-thiophene] scaffolds via a formal [3 + 2] annulation reaction of crotonate-derived sulfur ylides and β-ketothioamides

“…The library of thiazole derivatives has attracted the attention of synthetic chemists in recent years due to their significance in organic chemistry and drug discovery, and several new methodologies have been developed by modifying the original Hantzsch reaction. 4 Álvarez-Toledano and co-workers reported that they had developed a stereoselective one-pot method for the synthesis of a series of 2-(1,3-thiazolidin-2 Z -ylidene)acetophenones. 5 The Müller group reported that they were able to build N -benzyl aroyl- S , N -ketene acetals by annulating aroyl chlorides with N -benzyl 2-methyl benzothiazolium salts.…”

Electrochemical single-step N-acylation and S-cyclization synthesis of thiazolimide via radical process

“…37 Pharmaceutical researchers have showed great interest in green approaches for the development of medicinal products. 38 In recent decades continuous attempts have been made to incorporate green strategies in the synthesis of thiazole and its derivatives (Fig. 2).…”

Synthesis and Antimicrobial Study of Thiophene Clubbed Thiazolyl Carbohydrazides

“…Acid hydrazides can be synthesized from esters 20,21 . Although thiazole and substituted thiazoles can be synthesized by various routes [22][23][24][25] , Hantzsch synthesis [26][27][28] is an efficient and widely preferred route of thiazole synthesis. Phenacyl bromides are widely used in thiazole synthesis 29 .…”