Green tea and liver cancer

Bravi, Francesca; Vecchia, Carlo La; Turati, Federica

doi:10.21037/hbsn.2017.03.07

Cited by 9 publications

(8 citation statements)

References 16 publications

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“…These compounds promote increased the plasma concentration of cholesterol in humans [35]. Also, coffee drinking causes hepatocellular carcinoma were also reported in Italy [70]. Also, higher levels of coffee drink have lower a rate of incident arterial fibrillation (AF) [71].…”

Section: Health Risks Of Coffee Consumptionmentioning

confidence: 99%

Review on Health Benefit and Risk of Coffee Consumption

Wachamo¹

2017

Med Aromat Plants

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Coffee is the world's beloved drink that is the most regularly consumed caffeine-containing beverage next to water and tea. It contains a multipart combination of chemicals constituents, which associated with health benefits, most consumers, begin their day with a minimum a cup of coffee after eating food, and end their workday with coffee. It is considered as a significant part of modern daily life because it has an alerting outcome on the human brain. Opposing this, various groups report experiencing uneven health risks thus hesitant to drink coffee, this suggests individual disparity to coffee intolerance. The aim of this review was to in brief summarize health benefits and risks coffee consumption. Most of the informative reports suggested that long-term consumption of coffee and decaffeinated coffee can reduce the risk of many diseases. Among these it is used to boosts our physical performance, burn fat, reduces risk of stroke, liver, prostate and colorectal cancer by 20%, risk of Parkinson's disease by 25%, lower risk of Type II diabetes, reduces risk of dementia and protects our mind, brightens our mood, helps us to fight depression and minimize risk of suicide by 50%. In addition, coffee consumers have less risk of heart disease, with strongly integrated DNA. Also reports that coffee drinking has also naturally extended sleep latency, minimizes total sleep time and its effectiveness, and worsened supposed sleep feature.However, from positive health prospect of coffee consumption, a recent study finds coffee consumption does not always provide protective benefits because overdrinking is associated with negative impact or risk on our health. Some negative impact of coffee consumption on our health; it reduces appetite levels for food, impact on pregnant women, on people with cholesterol, cause insomnia and restlessness, breast tissue cysts in women, incontinence digestive disorders, and risk of headaches. In addition, decrease fertility probability in female and male, cause allergies and miscarriage, forceful heart contractions, anxiety, depression and the need for anxiety medication, inhibits collagen production in the skin of human being, less hearing loss improvement, does not help with extended sleep deprivation interferes with ossification and could also lead to greater risk of bone fracture. Finally, the most recent studies reported that coffee consumption is beneficial for our health when it is optimum range approximately four cups on average. The supplementary research will be crucial to make clear that both the health benefits and risk of coffee consumption.

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Section: Health Risks Of Coffee Consumptionmentioning

confidence: 99%

Review on Health Benefit and Risk of Coffee Consumption

Wachamo¹

2017

Med Aromat Plants

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“…EGCG has always achieved a milestone in the quest for cancer therapy. It has been observed to suppress breast cancer [5][6][7], prostate cancer [8][9][10], lung cancer [11][12][13], pancreatic cancer [14][15][16], and liver cancer [17,18]. All of this anticancer activity by EGCG has previously been demonstrated that EGCG is the most effective cancer chemopreventive polyphenol in green tea [19].…”

Section: Introductionmentioning

confidence: 89%

Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2α/ATF4 and IRE1α

Nesran

Shafie

Ishak

et al. 2019

BioMed Research International

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Epigallocatechin-3-gallate (EGCG) is the most abundant bioactive polyphenolic compound among the green tea constituents and has been identified as a potential anticancer agent in colorectal cancer (CRC) studies. This study was aimed to determine the mechanism of actions of EGCG when targeting the endoplasmic reticulum (ER) stress pathway in CRC. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay was performed on HT-29 cell line and normal cell line (3T3) to determine the EGCG toxicity. Next, western blot was done to observe the expression of the related proteins for the ER stress pathway. The Caspase 3/7 assay was performed to determine the apoptosis induced by EGCG. The results demonstrated that EGCG treatment was toxic to the HT-29 cell line. EGCG induced ER stress in HT-29 by upregulating immunoglobulin-binding (BiP), PKR-like endoplasmic reticulum kinase (PERK), phosphorylation of eukaryotic initiation factor 2 alpha subunit (eIF2α), activating transcription 4 (ATF4), and inositol-requiring kinase 1 alpha (IRE1α). Apoptosis was induced in HT-29 cells after the EGCG treatment, as shown by the Caspase 3/7 activity. This study indicates that green tea EGCG has the potential to inhibit colorectal cancer cells through the induction of ER stress.

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“…Epidemiological investigations and experimental studies have shown that EGCG exerts an important role by its anticancer and cancer chemopreventive properties. It has been observed to suppress breast cancer [101], lung cancer [102], pancreatic cancer [103], and liver cancer [104]. In vivo studies have demonstrated an inhibitory effect of EGCG on inflammation and obesity-related colon carcinogenesis in rodent models [105].…”

Section: Egcgmentioning

confidence: 99%

Polyphenols of the Mediterranean Diet and Their Metabolites in the Prevention of Colorectal Cancer

et al. 2021

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The Mediterranean diet is a central element of a healthy lifestyle, where polyphenols play a key role due to their anti-oxidant properties, and for some of them, as nutripharmacological compounds capable of preventing a number of diseases, including cancer. Due to the high prevalence of intestinal cancer (ranking second in causing morbidity and mortality), this review is focused on the beneficial effects of selected dietary phytophenols, largely present in Mediterranean cooking: apigenin, curcumin, epigallocatechin gallate, quercetin-rutine, and resveratrol. The role of the Mediterranean diet in the prevention of colorectal cancer and future perspectives are discussed in terms of food polyphenol content, the effectiveness, the plasma level, and the importance of other factors, such as the polyphenol metabolites and the influence of the microbiome. Perspectives are discussed in terms of microbiome-dependency of the brain-second brain axis. The emergence of polyphenol formulations may strengthen the efficiency of the Mediterranean diet in the prevention of cancer.

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Green tea and liver cancer

Cited by 9 publications

References 16 publications

Review on Health Benefit and Risk of Coffee Consumption

Review on Health Benefit and Risk of Coffee Consumption

Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2α/ATF4 and IRE1α

Polyphenols of the Mediterranean Diet and Their Metabolites in the Prevention of Colorectal Cancer

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