Green tea (Camellia sinensis) extract inhibits both the metastasis and osteolytic components of mammary cancer 4T1 lesions in mice

Luo, Ke-Wang; Ko, Chun‐Hay; Yue, Grace Gar-Lee; Lee, Julia Kin-Ming; Li, Kai-Kai; Lee, Michelle; Li, Gang; Fung, Kwok‐Pui; Leung, Ping‐Chung; Lau, Clara Bik‐San

doi:10.1016/j.jnutbio.2013.11.013

Cited by 56 publications

(33 citation statements)

References 30 publications

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“…All 4T1-bearing mice were injected subcutaneously with 4T1 cells (4x10 5 ) suspended in 0.2 ml of PBS in the mammary fat pads (21) in the right flank of each mouse when treated for 14 days. The tumor was detected through palpation around the induction area.…”

Section: Methodsmentioning

confidence: 99%

The effect of royal jelly on the growth of breast cancer in mice

et al. 2017

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Abstract. Due to various pharmacological properties, including antioxidative, anti-inflammatory and antibiotic properties, royal jelly (RJ) has been widely consumed in daily diets in numerous countries. In the present study, the effect of RJ on 4T1-bearing mice was investigated. The study was performed by feeding 4T1-bearing mice with RJ using either the prophylactic-therapeutic (PTRJ) or therapeutic (TRJ) method. The experimental results for the PTRJ group demonstrated that the weight of tumor was significantly reduced (RJ 0.5 and 1.5 g/kg); and in the serum, the levels of interleukin (IL)-2 (RJ 0.5 and 1.5 g/kg), interferon (IFN)-α, superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) were significantly elevated, but the concentrations of IL-4 (RJ 0.5 and 1.5 g/kg) and IL-10 (RJ 1.0 g/kg) were significantly decreased. In addition, the activities of T-AOC and glutathione reductase (GR) were significantly improved in the liver, whereas in the kidney, the activities of T-AOC and GR were significantly increased only under the dose of 0.5 g/kg. For the TRJ group, the antitumor effect of RJ was not significant; the change in IL-2, IFN-α, SOD and T-AOC levels in the serum, and the change in T-AOC and GR in liver were similar to those observed in the PTRJ groups. RJ treatment was demonstrated to reduce the development of breast tumor in mice, and simultaneously improve the antioxidant capacity of the serum, liver and kidney, particularly using the prophylactic-therapeutic method. These results corroborated the efficacy of RJ supplementation in diets. The results of the present study suggest that the antioxidant and immunomodulatory activities of RJ serve an important role on antitumor growth.

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Section: Methodsmentioning

confidence: 99%

The effect of royal jelly on the growth of breast cancer in mice

et al. 2017

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“…CS has several, in vitro and in vivo-antimetastasis and osteolytic properties (Luo et al 2014). The activities of CS may be attributed to the presence of a number of catechins with epigallocatechin-3-gallate (EGCG, Fig.…”

Section: Catechins In Teamentioning

confidence: 99%

“…CS has potent antitumor and antimetastasis effect in breast cancer (Luo et al 2014;Yiannakopoulou 2014). However, lipid-soluble CS polyphenols, polyphenols esterified with fatty acids, are shown to be more potent in containing hepatoma and precancerous lesions by inhibition of cellular proliferation and DNA damage (Shen et al 2014).…”

Section: Mechanism Of Action Of Egcgmentioning

confidence: 99%

Green tea polyphenols and their potential role in health and disease

2015

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There is a growing body of evidence that plant polyphenols such as resveratrol, anthocyanins, catechins, and terpenes like taxol are effectively used in the treatment of chronic conditions including cancer, Alzheimer, Parkinsonism, diabetes, aging, etc. The link between oxidative stress and inflammation is well accepted. Thus, the mechanism of action of these natural products is partly believed to be through their significant antioxidant properties. The main constituent of green tea, with clinical significance, is epigallocatechin gallate (EGCG). It has been associated with antitumor, anti-Alzheimer, and anti-aging properties, improve redox status at the tissue level possibly preventing system level structural damage. This review focuses on EGCG and its potential therapeutic role in health and disease.

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“…EGCG can effectively inhibit the invasion and migration of breast cancer cells, resulting in decreased lung and liver metastasis [70]. Tea catechins showed an inhibitory effect on the migratory and invasive potential of breast cancer cells [71,72].…”

Section: Mechanism Of Tea Catechins In Suppressing Breast Cancermentioning

confidence: 99%

Suppressive Effects of Tea Catechins on Breast Cancer

Xiang

Wang²,

et al. 2016

Nutrients

110

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Tea leaf (Camellia sinensis) is rich in catechins, which endow tea with various health benefits. There are more than ten catechin compounds in tea, among which epigallocatechingallate (EGCG) is the most abundant. Epidemiological studies on the association between tea consumption and the risk of breast cancer were summarized, and the inhibitory effects of tea catechins on breast cancer, with EGCG as a representative compound, were reviewed in the present paper. The controversial results regarding the role of tea in breast cancer and areas for further study were discussed.

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Green tea (Camellia sinensis) extract inhibits both the metastasis and osteolytic components of mammary cancer 4T1 lesions in mice

Cited by 56 publications

References 30 publications

The effect of royal jelly on the growth of breast cancer in mice

The effect of royal jelly on the growth of breast cancer in mice

Green tea polyphenols and their potential role in health and disease

Suppressive Effects of Tea Catechins on Breast Cancer

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