Green tea (Camellia sinensis) for the prevention of cancer

Filippini, Tommaso; Malavolti, Marcella; Borrelli, Francesca; Izzo, Angelo A.; Fairweather‐Tait, Susan J.; Horneber, Markus; Vinceti, Marco

doi:10.1002/14651858.cd005004.pub3

Cited by 153 publications

(92 citation statements)

References 322 publications

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“…Experimental trials have suggested that green tea catechins (GTCs) have inhibitory effects on carcinogenesis and cancer cell growth [ 105 ]. According to a recent Cochrane meta-analysis, the relative risk for developing PCa is reduced among green tea consumers [ 106 ]. Overall, GTCs appear to affect multiple cancer signaling pathways, and many RCTs have evaluated their effects in vivo ( Table 5 ).…”

Section: Antioxidants and Psa Kineticsmentioning

confidence: 99%

Dietary Factors and Supplements Influencing Prostate-Specific Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials

et al. 2020

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The quest for dietary patterns and supplements efficient in down-regulating prostate-specific antigen (PSA) concentrations among men with prostate cancer (PCa) or increased PCa risk has been long. Several antioxidants, including lycopene, selenium, curcumin, coenzyme Q10, phytoestrogens (including isoflavones and flavonoids), green tea catechins, cernitin, vitamins (C, E, D) and multivitamins, medicinal mushrooms (Ganoderma lucidum), fruit extracts (saw palmetto, cranberries, pomegranate), walnuts and fatty acids, as well as combined supplementations of all, have been examined in randomized controlled trials (RCTs) in humans, on the primary, secondary, and tertiary PCa prevention level. Despite the plethora of trials and the variety of examined interventions, the evidence supporting the efficacy of most dietary factors appears inadequate to recommend their use.

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Section: Antioxidants and Psa Kineticsmentioning

confidence: 99%

Dietary Factors and Supplements Influencing Prostate-Specific Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials

et al. 2020

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“…A study published in the Cochrane Database of Systematic Reviews assessed possible associations between green tea consumption and the risk of cancer incidence and mortality, as well as safety data and quality of life as secondary outcomes. The authors reviewed 11 experimental studies, including a total of 1,795 participants consuming either green tea extract or a placebo and 131 non-experimental studies (>1,100,000 participants) (8). A beneficial effect due to green tea consumption emerged only for the high-intake subjects at specific cancer sites from randomized control trials and case-control studies; however methodological limitations, such as the low number and size of the studies as well as inconsistency with the results of cohort studies, limit the interpretability of the relative risk estimates.…”

Section: Introductionmentioning

confidence: 99%

Polyphenols in cancer prevention: New insights (Review)

et al. 2020

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A huge volume of literature data suggests that a diet rich in fruits and vegetables, mostly due to the contribution of natural polyphenols, could reduce the incidence of specific cancers. Resveratrol, epigallocatechin gallate and curcumin are among the most extensively studied polyphenols: The majority of the effects attributed to these compounds are linked to their antioxidant and anti-inflammatory properties. The multiple mechanisms involved include the modulation of molecular events and signaling pathways associated with cell survival, proliferation, differentiation, migration, angiogenesis, hormonal activities, detoxification enzymes and immune responses. Notwithstanding their promising role in cancer prevention and treatment, polyphenols often have a poor bioavailability when administered as pure active principles, representing an important limit to their use. However, the bioavailability and thus the efficacy of these compounds can be improved by their administration in combination with other phytochemicals, with anticancer drugs or in polyphenol-loaded nanotechnology-based delivery systems. The possibility of combining conventional drugs with polyphenols offers very valuable advantages, such as the building of more efficient anticancer therapies with less side-effects on the health of patients. The present review focuses on current knowledge regarding the interactions between natural polyphenols and cancer development in order to gain a clearer comprehension of the potential mechanisms through which individual foods and food components may be exploited to reduce cancer risk. Contents 1. Introduction 2. Literature search 3. Classification of polyphenols 4. Prostate cancer 5. Colon cancer 6. Breast cancer 7. Lung cancer 8. Bladder cancer 9. Skin cancer 10. Pancreatic cancer 11. Leukemia 12. Conclusion

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“…In addition, some studies suggested a risk increase in certain types of cancers such as esophageal and gynecological cancers in green tea consumption [ 14 ] and bladder and lung cancers in coffee consumption ( Table 2 ). The reason for these observations may be clarified in future studies.…”

Section: Discussionmentioning

confidence: 99%

“…When observational epidemiological studies were reviewed on over 1,100,000 participants from 46 cohort studies and 85 case-control studies [ 14 ], in three studies involving 52,479 participants, a lower overall cancer incidence (summary relative risk (RR) = 0.83, 95% confidence interval (CI) = 0.65–1.07) was found for the highest intake of green tea compared with the lowest consumption. For most of the site-specific cancers, a decreased RR was found by this comparison.…”

Section: Anti-cancer Effects Of Green Teamentioning

confidence: 99%

Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid

et al. 2020

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Tea and coffee are consumed worldwide and epidemiological and clinical studies have shown their health beneficial effects, including anti-cancer effects. Epigallocatechin gallate (EGCG) and chlorogenic acid (CGA) are the major components of green tea polyphenols and coffee polyphenols, respectively, and believed to be responsible for most of these effects. Although a large number of cell-based and animal experiments have provided convincing evidence to support the anti-cancer effects of green tea, coffee, EGCG, and CGA, human studies are still controversial and some studies have suggested even an increased risk for certain types of cancers such as esophageal and gynecological cancers with green tea consumption and bladder and lung cancers with coffee consumption. The reason for these inconsistent results may have been arisen from various confounding factors. Cell-based and animal studies have proposed several mechanisms whereby EGCG and CGA exert their anti-cancer effects. These components appear to share the common mechanisms, among which one related to reactive oxygen species is perhaps the most attractive. Meanwhile, EGCG and CGA have also different target molecules which might explain the site-specific differences of anti-cancer effects found in human studies. Further studies will be necessary to clarify what is the mechanism to cause such differences between green tea and coffee.

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Green tea (Camellia sinensis) for the prevention of cancer

Cited by 153 publications

References 322 publications

Dietary Factors and Supplements Influencing Prostate-Specific Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials

Dietary Factors and Supplements Influencing Prostate-Specific Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials

Polyphenols in cancer prevention: New insights (Review)

Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid

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