Green Tea (Camellia sinensis) Protects Against Arsenic Neurotoxicity via Antioxidative Mechanism and Activation of Superoxide Dismutase Activity

Maiti, Smarajit; Acharyya, Nirmallya; Ghosh, Tamal; Ali, Sk. Sajed; Manna, Emili; Nazmeen, Aarifa; Sinha, Nirmalya Kumar

doi:10.2174/1871524917666170201145102

Cited by 21 publications

(18 citation statements)

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“…These are highly enriched with phytochemicals, polyphenols like flavonoids. Earlier our laboratory has demonstrated the anti-carcinogenic role of green tea extract [13,14]. It decisively helps in DNA protections by scavenging free radicals and that efficacy was found to be even greater than the known specific radical-scavengers [14,15].…”

Section: Resultsmentioning

confidence: 95%

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Epigallocatechin-Gallate and Theaflavin-Gallate Interaction in SARS CoV-2 Spike-Protein Central-Channel with Reference to the Hydroxychloroquine Interaction: Bioinformatics and Molecular Docking Study

Maiti¹,

Banerjee²

2020

Preprint

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SARS CoV-2 or COVID-19 pandemic global-outbreak created the most unstable situation of human health-economy. Last two decades different parts of the word experienced smaller or bigger outbreak related to human-coronaviruses. The spikeglycoproteins of the COVID-19 (similar to SARS-CoV) attach to the angiotensin-converting-enzyme (ACE-2) and transit over a stabilized open-state for the viral-internalization to the host-cells and propagate with great efficacy. Higher rate of mutability makes this virus unpredictable/less-sensitive to the protein/nucleic-acid based-drugs. In this emergent situation, drug-induced destabilization of spike-binding to RBD could be a good strategy. In the current study we demonstrated by Bioinformatics (CASTp: Computed-Atlas-of-Surface-Topography, PyMol: molecular-visualization) and Molecular docking (PatchDock) experiments that tea flavonoids catechin-products mainly EGCG or other like theaflavin gallate demonstrated higher Atomic Contact Energy (ACE), surface area and more amino-acid interactions than hydroxychloroquine (HCQ) during binding in the central channel of the spike-protein. Moreover, out of three distinct binding-sites (I, II and III) of spike core when HCQ binds only with site III (farthest from the nCoV-RBD of ACE2 contact), EGCG and TG bind all three sites. As because site I and II is in closer contact with open state location and viral-host contact area so these drugs might have significant effects. Taking into account the toxicity/side-effects by CQ/HCQ, present drugs may be important. Our laboratory is working on tea flavonoids and other phytochemicals in the protection from toxicity, DNA/mitochondrial damage, inflammation etc. The present data might be helpful for further analysis of flavonoids in this emergent pandemic situation.

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Section: Resultsmentioning

confidence: 95%

“…Tea flavonoids have been demonstrated as strong anti-toxicant, anti-oxidant and anti-inflammatory agents. Anti-tumerigenic role of catechin derivatives especially EGCG has been shown decisively by several laboratories [13,14,15]. Regarding the anti-viral role tea flavonoids have been shown to be strong agent [16].…”

Section: Introductionmentioning

confidence: 99%

Epigallocatechin-Gallate and Theaflavin-Gallate Interaction in SARS CoV-2 Spike-Protein Central-Channel with Reference to the Hydroxychloroquine Interaction: Bioinformatics and Molecular Docking Study

Maiti¹,

Banerjee²

2020

Preprint

Self Cite

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“…Protective effect of green tea against lipid peroxidation products is noticed in rat liver, blood serum and in the brain. In the central nervous tissue the activity of superoxide dismutase and glutathione peroxidase decreased while the activity of glutathione reductase and catalase increased after drinking green tea [30,31]. Microglial Cells are noticed to be more threatened by oxidative stress initiated during hypoxia/reperfusion events.…”

Section: Flavonoids Also Protect Non-hepatic Organsmentioning

confidence: 99%

Flavonoids green tea against oxidant stress and inflammation with related human diseases

Maiti¹,

Nazmeen

Medda³

et al. 2019

Clinical Nutrition Experimental

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“…In an animal model of arsenic neurotoxicity, 10 mg/kg of green tea extract could represent a strong neuroprotective activity through reduction of arsenic‐induced oxidative damage. The biomarkers of inflammation including CRP, LDH, and TNF‐α were also increased in control animals but were significantly lowered following exposure to green tea (Maiti et al, ). In aluminum chloride‐induced toxicity in rats which mimics the symptoms of AD, green tea infusion could reverse behavioral alterations of the animals along with regulation of COX and AChE activities, and total glutathione content (Jelenković et al, ).…”

Section: Neuropsychopharmacological Mechanisms Of Green Tea Catechinsmentioning

confidence: 99%

Role of green tea catechins in prevention of age‐related cognitive decline: Pharmacological targets and clinical perspective

Farzaei

Bahramsoltani

Abbasabadi

et al. 2018

Journal Cellular Physiology

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Over the past decade, a wide range of scientific investigations have been performed to reveal neuropathological aspects of cognitive disorders; however, only limited therapeutic approaches currently exist. The failures of conventional therapeutic options as well as the predicted dramatic rise in the prevalence of cognitive decline in the coming future show the necessity for novel therapeutic agents. Recently, a wide range of research has focused on pharmacological activities of green tea catechins worldwide. Current investigations have clarified mechanistic effects of the catechins in inflammatory cascades, oxidative damages, different cellular transcription as well as transduction pathway in various body systems. It has been demonstrated that green tea polyphenols prevent age-related neurodegeneration through improvement of endogenous antioxidant defense mechanisms, modulation of neural growth factors, attenuation of neuroinflammatory pathway, and regulation of apoptosis. The catechins exhibited beneficial effects in cellular and animal models of neurodegenerative diseases including Alzheimer's disease, MS, and Parkinson's disease. The present review discusses the current pharmacological targets, which can be involved in the treatment of cognitive decline and addresses the action of catechin derivatives elicited from green tea on the multiple neural targets.

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Green Tea (Camellia sinensis) Protects Against Arsenic Neurotoxicity via Antioxidative Mechanism and Activation of Superoxide Dismutase Activity

Abstract: Taken together, this investigation indicates the potent neuroprotective and antioxidative efficiencies of Camellia sinensis against arsenic-induced oxidative threat.

Cited by 21 publications

References 0 publications

Epigallocatechin-Gallate and Theaflavin-Gallate Interaction in SARS CoV-2 Spike-Protein Central-Channel with Reference to the Hydroxychloroquine Interaction: Bioinformatics and Molecular Docking Study

Epigallocatechin-Gallate and Theaflavin-Gallate Interaction in SARS CoV-2 Spike-Protein Central-Channel with Reference to the Hydroxychloroquine Interaction: Bioinformatics and Molecular Docking Study

Flavonoids green tea against oxidant stress and inflammation with related human diseases

Role of green tea catechins in prevention of age‐related cognitive decline: Pharmacological targets and clinical perspective

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