Green tea catechins: defensive role in cardiovascular disorders

Bhardwaj, Pooja; Kumari, Deepa

doi:10.1016/s1875-5364(13)60051-5

Cited by 80 publications

(65 citation statements)

References 86 publications

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“…When the vascular endothelium is damaged, platelets usually respond rapidly and aggregate to form plugs at the damage site, and may also form clots that could lead to vessel occlusion [8,89]. Many of the studies on platelet aggregation have been carried out using various animal platelets.…”

Section: Platelet Aggregationmentioning

confidence: 99%

An Update on the Health Benefits of Green Tea

Reygaert

2017

Beverages

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Abstract:Green tea, which is produced from the leaves of the Camellia sinensis plant, is one of the most popular beverages worldwide. Over the past 30 years or more, scientists have studied this plant in respect to potential health benefits. Research has shown that the main components of green tea that are associated with health benefits are the catechins. The four main catechins found in green tea are: (−)-epicatechin (EC), (−)-epicatechin-3-gallate (ECG), (−)-epigallocatechin (EGC), and (−)-epigallocatechin-3-gallate (EGCG). Of these four, EGCG is present in the largest quantity, and so has been used in much of the research. Among the health benefits of green tea are: anticarcinogenic, anti-inflammatory, antimicrobial, and antioxidant properties, and benefits in cardiovascular disease and oral health. Research has been carried out using various animal models and cells lines, and is now more and more being carried out in humans. This type of research will help us to better understand the direct benefits of green tea. This review will focus primarily on research conducted using human subjects to investigate the health benefits of green tea.

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Section: Platelet Aggregationmentioning

confidence: 99%

An Update on the Health Benefits of Green Tea

Reygaert

2017

Beverages

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“…Furthermore, as tea consumption is high globally, it could be proposed that even modest health effects in humans may have major beneficial implications for global population health and reduction in CVD risk [21,35]. This is in alignment with recently published European data, regarding the prevention strategies against CVD, reporting that despite the decrease in CVD mortality within the last decade, there are significant differences between countries.…”

Section: Introductionmentioning

confidence: 60%

“…Despite the variability of effect, with some studies finding conflicting outcomes [28][29][30], the majority of the current literature appears to support the positive therapeutic effect derived from GT consumption [1,[9][10][11][12][13][14][15][31][32][33][34]. Furthermore, as tea consumption is high globally, it could be proposed that even modest health effects in humans may have major beneficial implications for global population health and reduction in CVD risk [21,35]. This is in alignment with recently published European data, regarding the prevention strategies against CVD, reporting that despite the decrease in CVD mortality within the last decade, there are significant differences between countries.…”

Section: Methodsmentioning

confidence: 99%

The Effect of Dietary Supplementation of Green Tea Catechins on Cardiovascular Disease Risk Markers in Humans: A Systematic Review of Clinical Trials

et al. 2016

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Green tea catechins (GTCs) are secondary plant metabolites that have been associated with health benefits in human trials. As such, they have the potential to reduce cardiovascular disease (CVD) risk; however, results are not consistent. This systematic review of the published data assessed the putative effect of GTCs supplementation on anthropometric, blood pressure, and biochemical measures associated with CVD risk. It was conducted in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines exploring four major electronic databases (MEDLINE, Cochrane Library, Web of Science, and Scopus). Studies were included if they were published in peer-reviewed journals in English from 1990 until October 2015, and were human double-blind randomized and placebo-controlled trials (RCTs). From 122,428 articles initially identified, after two levels of screening, seven studies met the inclusion criteria. The review revealed consistent and significant (p ď 0.05) reductions in body mass index (BMI), blood pressure and plasma lipids; however, this effect would have been less if between-group effects had been considered. The current evidence base also has considerable methodological limitations due to suboptimal statistical methods used in data analyses. Future research efforts must aim to rectify this paucity of evidence with well-designed and well-reported prospective studies.

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“…Catechin and epicatechin, the two most studied compounds from proanthocyanidins, have been reported to have an impressive protective role on cardiovascular system. It is believed that their effectiveness in reducing the risk of myocardial ischaemia, and congestive heart failure have apparently been associated with their antioxidant, anti-inflammatory, and vasodilatory activities [12,14,16]. Owing to the fact that condensed tannins scavenge the free hydroxyl and superoxide radicals, they could prevent cardiomyocytes and myocardium against oxidative stress, reduce reperfusion-induced VF and VT, and increase mitochondrial and respiratory chain enzymes (aerobic metabolism induction) as well [7,11,17,22,29].…”

Section: Discussionmentioning

confidence: 99%