2022
DOI: 10.3390/nu14194167
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Green Tea Catechins Modulate Skeletal Development with Effects Dependent on Dose, Time, and Structure in a down Syndrome Mouse Model

Abstract: Altered skeletal development in Down syndrome (DS) results in a brachycephalic skull, flattened face, shorter mandibular ramus, shorter limbs, and reduced bone mineral density (BMD). Our previous study showed that low doses of green tea extract enriched in epigallocatechin-3-gallate (GTE-EGCG), administered continuously from embryonic day 9 to postnatal day 29, reduced facial dysmorphologies in the Ts65Dn (TS) mouse model of DS, but high doses could exacerbate them. Here, we extended the analyses to other skel… Show more

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Cited by 6 publications
(36 citation statements)
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“…Pairwise comparison between groups at single timepoints were performed as described in (Llambrich et al, 2022). Normality was assessed for each comparison using Shapiro-Wilk and homoscedasticity was assessed using an F-test.…”
Section: Methodsmentioning
confidence: 99%
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“…Pairwise comparison between groups at single timepoints were performed as described in (Llambrich et al, 2022). Normality was assessed for each comparison using Shapiro-Wilk and homoscedasticity was assessed using an F-test.…”
Section: Methodsmentioning
confidence: 99%
“…Since time always resulted in a significant difference, as mice grew and their lung volume increased accordingly over time, we focused on differences in the growth patterns as reflected by the interaction effect. Pairwise comparison between groups at single timepoints were performed as described in (Llambrich et al, 2022). Normality was assessed for each comparison using Shapiro-Wilk and homoscedasticity was assessed using an F-test.…”
Section: Echocardiographic Analysismentioning
confidence: 99%
“…Down syndrome (DS) is a developmental disorder with structural, functional, molecular, and genetic alterations that show a dynamic onset and severity (Antonarakis et al, 2020; de Moraes et al, 2008; Grieco et al, 2015; Keeling et al, 1997; LaCombe & Roper, 2020; Llambrich, González-Colom, et al, 2022; McCarron et al, 2017; Steingass et al, 2011). The alterations associated with DS simultaneously affect multiple systems that are likely interrelated over development, with changes in one system modulating the others (Llambrich, González, et al, 2022).…”
Section: Introductionmentioning
confidence: 99%
“…These genetic alterations do not fully represent Down syndrome’s aneuploidy and other mouse and rat models have been developed recently that more faithfully represent the trisomic nature of DS (Kazuki et al, 2020; Kazuki et al, 2022). However, in this study we used the Ts65Dn mouse model because it recapitulates the main skeletal, brain, cognitive, brain metabolite, and genetic alterations associated with DS (Blazek et al, 2011; Costa et al, 2010; Dierssen et al, 2002; Escorihuela et al, 1998; Gupta et al, 2016; Huang et al, 2000; Llambrich, González, et al, 2022; Même, 2014; Starbuck et al, 2021); and the effects of GTE-EGCG pharmacological modulation have been extensively evaluated using this mouse model (Catuara-Solarz et al, 2016; Goodlett et al, 2020; Jamal et al, 2022; Llambrich, González, et al, 2022; McElyea et al, 2016; Stagni et al, 2016; Starbuck et al, 2021; Stringer et al, 2017).…”
Section: Introductionmentioning
confidence: 99%
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