Green tea (–)‐epigallocatechin gallate inhibits <scp>IGF</scp>‐<scp>I</scp> and <scp>IGF</scp>‐<scp>II</scp>stimulation of 3T3‐<scp>L</scp>1 preadipocyte mitogenesis via the 67‐k<scp>D</scp>a laminin receptor, but not <scp>AMP</scp>‐activated protein kinase pathway

Ku, Hui Chen; Liu, Hang Seng; Hung, Pei Fang; Chen, Chialin; Liu, Hsien Chun; Chang, Hsin Huei; Tsuei, Yi Wei; Shih, Li Jane; Lin, Ching Ling; Lin, Chih Ming; Kao, Ying-Jer

doi:10.1002/mnfr.201100438

Cited by 39 publications

(33 citation statements)

References 54 publications

(158 reference statements)

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“…In more specialized conditions, LAMR has also been shown to interact with the GM‐CSF receptor (Chen et al, ; Ando et al, ), insulin‐like growth factor receptors I and II (Ku et al, ), insulin receptor and insulin receptor substrates (IRS‐1/2/4) (Ku et al, ), the T‐cell specific adaptor protein TSAd (Park et al, ). LAMR also potentially serves as a receptor for both the anti‐angiogenic agent pigment epithelium‐derived factor (PEDF) (Bernard et al, ) and the pro‐survival pro‐angiogenic midkine protein, which may induce nuclear localization of LAMR (Salama et al, ).…”

Section: /67‐kda Laminin Receptor Functionmentioning

confidence: 99%

Looking into laminin receptor: critical discussion regarding the non‐integrin 37/67‐kDalaminin receptor/RPSAprotein

2015

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The 37/67-kDa laminin receptor (LAMR/RPSA) was originally identified as a 67-kDa binding protein for laminin, an extracellular matrix glycoprotein that provides cellular adhesion to the basement membrane. LAMR has evolutionary origins, however, as a 37-kDa RPS2 family ribosomal component. Expressed in all domains of life, RPS2 proteins have been shown to have remarkably diverse physiological roles that vary across species. Contributing to laminin binding, ribosome biogenesis, cytoskeletal organization, and nuclear functions, this protein governs critical cellular processes including growth, survival, migration, protein synthesis, development, and differentiation. Unsurprisingly given its purview, LAMR has been associated with metastatic cancer, neurodegenerative disease and developmental abnormalities. Functioning in a receptor capacity, this protein also confers susceptibility to bacterial and viral infection. LAMR is clearly a molecule of consequence in human disease, directly mediating pathological events that make it a prime target for therapeutic interventions. Despite decades of research, there are still a large number of open questions regarding the cellular biology of LAMR, the nature of its ability to bind laminin, the function of its intrinsically disordered C-terminal region and its conversion from 37 to 67 kDa. This review attempts to convey an in-depth description of the complexity surrounding this multifaceted protein across functional, structural and pathological aspects.

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Section: /67‐kda Laminin Receptor Functionmentioning

confidence: 99%

Looking into laminin receptor: critical discussion regarding the non‐integrin 37/67‐kDalaminin receptor/RPSAprotein

2015

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“…For example, plant extracts including polyphenols, resveratrol, curcumin, and proanthocyanidins, have become increasingly popular in the past decades for their anti-adipogenic properties [1,13,14]. It was also reported that herbal medicine was effective as potential therapy for fatty liver disease, diabetes, and metabolic syndrome [15].…”

Section: Introductionmentioning

confidence: 99%

Tenebrio molitor Larvae Inhibit Adipogenesis through AMPK and MAPKs Signaling in 3T3-L1 Adipocytes and Obesity in High-Fat Diet-Induced Obese Mice

Seo

Goo

Chung

et al. 2017

IJMS

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Despite the increasing interest in insect-based bioactive products, the biological activities of these products are rarely studied adequately. Larvae of Tenebrio molitor, the yellow mealworm, have been eaten as a traditional food and provide many health benefits. Therefore, we hypothesized that T. molitor larvae might influence adipogenesis and obesity-related disorders. In the present study, we investigated the anti-adipogenic and antiobesity effects of T. molitor larvae in vitro and in vivo. The lipid accumulation and triglyceride content in mature adipocytes was reduced significantly (up to 90%) upon exposure to an ethanol extract of T. molitor larvae, without a reduction in cell viability. Exposure also resulted in key adipogenic and lipogenic transcription factors. Additionally, in adipogenic differentiation medium the extract induced phosphorylation of adenosine monophosphate (AMP)-activated protein kinase and mitogen-activated protein kinases. Daily oral administration of T. molitor larvae powder to obese mice fed high-fat diet attenuated body weight gain. We also found that the powder efficiently reduced hepatic steatosis as well as aspartate and alanine transaminase enzyme levels in mice fed a high-fat diet. Our results suggest that T. molitor larvae extract has an antiobesity effect when administered as a food supplement and has potential as a therapeutic agent for obesity.

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“…It is ubiquitously expressed in mammals and functions as a redox enzyme implicated in mitochondrial ROS generation [19]. The other two isoforms of this family, p46shc and p52shc, have been described as adaptor proteins that can alter mitogen-activated protein kinase and Fos activation upon stimulation with epidermal growth factor and platelet-derived growth factor [20]. p66shc functionally differentiates from these isoforms.…”

Section: Introductionmentioning

confidence: 99%

Modulating the p66shc Signaling Pathway with Protocatechuic Acid Protects the Intestine from Ischemia-Reperfusion Injury and Alleviates Secondary Liver Damage

Wang

Chen

et al. 2014

The Scientific World Journal

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Intestinal ischemia-reperfusion (I/R) injury is a serious clinical pathophysiological process that may result in acute local intestine and remote liver injury. Protocatechuic acid (PCA), which has been widely studied as a polyphenolic compound, induces expression of antioxidative genes that combat oxidative stress and cell apoptosis. In this study, we investigated the effect of PCA pretreatment for protecting intestinal I/R-induced local intestine and remote liver injury in mice. Intestinal I/R was established by superior mesenteric artery occlusion for 45 min followed by reperfusion for 90 min. After the reperfusion period, PCA pretreatment markedly alleviated intestine and liver injury induced by intestinal I/R as indicated by histological alterations, decreases in serological damage parameters and nuclear factor-kappa B and phospho-foxo3a protein expression levels, and increases in glutathione, glutathione peroxidase, manganese superoxide dismutase protein expression, and Bcl-xL protein expression in the intestine and liver. These parameters were accompanied by PCA-induced adaptor protein p66shc suppression. These results suggest that PCA has a significant protective effect in the intestine and liver following injury induced by intestinal I/R. The protective effect of PCA may be attributed to the suppression of p66shc and the regulation of p66shc-related antioxidative and antiapoptotic factors.

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Green tea (–)‐epigallocatechin gallate inhibits IGF‐I and IGF‐IIstimulation of 3T3‐L1 preadipocyte mitogenesis via the 67‐kDa laminin receptor, but not AMP‐activated protein kinase pathway

Abstract: The results of this study suggest that EGCG mediates anti-IGF-I and anti-IGF-II signals in preadipocyte mitogenesis via the 67LR but not the AMPK pathway.

Cited by 39 publications

References 54 publications

Looking into laminin receptor: critical discussion regarding the non‐integrin 37/67‐kDalaminin receptor/RPSAprotein

Looking into laminin receptor: critical discussion regarding the non‐integrin 37/67‐kDalaminin receptor/RPSAprotein

Tenebrio molitor Larvae Inhibit Adipogenesis through AMPK and MAPKs Signaling in 3T3-L1 Adipocytes and Obesity in High-Fat Diet-Induced Obese Mice

Modulating the p66shc Signaling Pathway with Protocatechuic Acid Protects the Intestine from Ischemia-Reperfusion Injury and Alleviates Secondary Liver Damage

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