2022
DOI: 10.3389/fnut.2022.848223
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Green Tea Intake and Parkinson's Disease Progression: A Mendelian Randomization Study

Abstract: Epidemiological studies have suggested green tea intake was associated with a reduced risk of Parkinson's disease (PD). However, whether green tea intake has an effect on PD progression is unknown. To evaluate the role of green tea intake in PD progression, we conducted a two-sample Mendelian randomization analysis using summary statistics from genome-wide association studies of green tea intake (N = 64,949), age at onset (N = 28,568) and progression (N = 4,093) of PD. One standard deviation increase in geneti… Show more

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Cited by 12 publications
(5 citation statements)
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“…The Mendelian randomization (MR) method is an essential statistical method that utilizes instrumental variables (IVs) to study the genetic causality of exposure and outcome (22)(23)(24)(25). Some examples include causal associations between alcohol consumption and AD (26), herpesvirus infections and AD (27), and tea intake and Parkinson's disease (28). Compared with traditional observational studies, MR analysis is able to overcome reverse causation, as genes are relatively stable after fertilization (29).…”
Section: Introductionmentioning
confidence: 99%
“…The Mendelian randomization (MR) method is an essential statistical method that utilizes instrumental variables (IVs) to study the genetic causality of exposure and outcome (22)(23)(24)(25). Some examples include causal associations between alcohol consumption and AD (26), herpesvirus infections and AD (27), and tea intake and Parkinson's disease (28). Compared with traditional observational studies, MR analysis is able to overcome reverse causation, as genes are relatively stable after fertilization (29).…”
Section: Introductionmentioning
confidence: 99%
“…Interestingly, some studies have suggested the protective effect of tea is specific to black tea 47 . A two-sample Mendelian randomization study also did not verify the association between green tea intake and AAO 48 .…”
Section: Discussionmentioning
confidence: 99%
“…PD exhibits a strong correlation with nutritional factors, prompting numerous studies to investigate the association between food and PD risk, especially tea [ 31 , 32 ]. A Mendelian randomization study has found that green tea consumption reduces the risk of PD and indicates that a larger intake of green tea is linked to a slower rate of PD progression [ 33 ]. Ingestion of 3 or more cups of tea daily were discovered to have association with a reduction of PD risk [ 34 ].…”
Section: Discussionmentioning
confidence: 99%