Green tea polyphenol (−)-epigallocatechin gallate reduces matrix metalloproteinase-9 activity following transient focal cerebral ischemia

Park, Jong‐Wook; Hong, Jung-Seok; Lee, Kyoung-Suk; Kim, Hahn-Young; Lee, Jung-Jeung; Lee, Seong‐Ryong

doi:10.1016/j.jnutbio.2009.08.009

Cited by 54 publications

(30 citation statements)

References 41 publications

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“…In addition, the amino acid L-theanine in the tea leaves also shows a neuroprotective effect in animal models of stroke Zukhurova et al, 2013). In 824 addition to its antioxidant properties, the neuroprotective effects of EGCG may involve matrix metalloproteinase (MMP)-9 inhibition and Nrf2/HO1 activation (Sutherland et al, 2006;Park et al, 2010;Shah et al, 2010). Epidemiologic data suggest an inverse relationship of consumption of green tea and stroke incidence in the Japanese population (Tanabe et al, 2008).…”

Section: A Ischemia: Stroke and Myocardial Infarctionmentioning

confidence: 99%

Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System

et al. 2014

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Section: A Ischemia: Stroke and Myocardial Infarctionmentioning

confidence: 99%

Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System

et al. 2014

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“…In the context of cerebral ischemia, gelatinases MMP-2, and especially MMP-9, contribute to the pathological process by disturbing the cerebral vasculature integrity, leading to neuroinflammation, brain edema, and hemorrhages (2,37). In this context, (Ϫ)-epigallocatechin gallate has been reported to limit brain infract size and neuronal damage by inhibiting MMP-9 activity (37,38). In the present study, we demonstrate that MMP-9 activity was significantly higher in cerebral vessels from ATX mice than from WT mice and that a chronic treatment for 3 mo with CAT significantly prevented this rise in MMP-9 activity (Fig.…”

Section: Resultsmentioning

confidence: 99%

Catechin prevents severe dyslipidemia-associated changes in wall biomechanics of cerebral arteries in LDLr^−/−:hApoB^+/+ mice and improves cerebral blood flow

Bolduc

Baraghis

Duquette

et al. 2012

American Journal of Physiology-Heart and Circulatory Physiology

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Endothelial dysfunction and oxidative stress contribute to the atherosclerotic process that includes stiffening of large peripheral arteries. In contrast, our laboratory previously reported a paradoxical increase in cerebrovascular compliance in LDLr(-/-):hApoB(+/+) atherosclerotic (ATX) mice (7). We hypothesized that prevention of cerebral artery endothelial dysfunction with a chronic dietary antioxidant intake would normalize the changes in cerebral artery wall structure and biomechanics and prevent the decline in basal cerebral blood flow associated with atherosclerosis. Three-month-old ATX mice were treated, or not, for 3 mo with the polyphenol (+)-catechin (CAT; 30 mg·kg(-1)·day(-1)) and compared with wild-type controls. In isolated, pressurized cerebral arteries from ATX mice, CAT prevented endothelial dysfunction (deterioration of endothelium-dependent, flow-mediated dilations; P < 0.05), the inward hypertrophic structural remodeling (increase in the wall-to-lumen ratio; P < 0.05), and the rise in cerebrovascular compliance (rightward shift of the stress-strain curve measured in passive conditions, reflecting mechanical properties of the arterial wall; P < 0.05). Doppler optical coherence tomography imaging in vivo confirmed these findings, showing that cerebral compliance was higher in ATX mice and normalized by CAT (P < 0.05). CAT also prevented basal cerebral hypoperfusion in ATX mice (P < 0.05). Active remodeling of the cerebrovascular wall in ATX mice was further suggested by the increase (P < 0.05) in pro-metalloproteinase-9 activity, which was normalized by CAT. We conclude that, by preserving the endothelial function, a chronic treatment with CAT prevents the deleterious effect of severe dyslipidemia on cerebral artery wall structure and biomechanical properties, contributing to preserving resting cerebral blood flow.

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“…[22][23][24][25] In the studies involving liver and brain protection, 50-75 mg/kg EGCG was IP administered for 1-56 days. 14,26,27 Based on the evidence that both 1% EGCG in the diet for 6 weeks of administration and a single IP injection of 100 mg/kg EGCG have adverse effects on mice, it seems obvious that the efficacious doses of EGCG including chemopreventive doses are not far from its toxic dose levels; furthermore, some efficacious doses actually overlap with the toxic doses.…”

Section: Efficacious and Toxic Doses Of Egcgmentioning

confidence: 99%

Encapsulated nanoepigallocatechin-3-gallate and elemental selenium nanoparticles as paradigms for nanochemoprevention

Zhang¹

2012

IJN

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Chemoprevention that impedes one or more steps in carcinogenesis, via long-term administration of naturally occurring or synthetic compounds, is widely considered to be a crucial strategy for cancer control. Selenium (Se) has chemopreventive effects, but its application is limited due to a low therapeutic index as shown in numerous animal experiments. In contrast to Se, which was known for its toxicity prior to the discovery of its beneficial effects, the natural compound epigallocatechin-3-gallate (EGCG) was originally considered to be nontoxic. Due to its preventive effects on many types of cancer in various animal models, EGCG has been regarded as a prime example of a promising chemopreventive agent without major toxicity concerns. However, very recently, evidence has accumulated showing that efficacious doses of EGCG used in health promotion may not be far from its toxic dose level. Therefore, both Se and EGCG need to be modified by novel pharmaceutical technologies to attain enhanced efficacy and/or reduced toxicity. Nanotechnology may be one of these technologies. In support of this hypothesis, the characteristics of polylactic acid and polyethylene glycol-encapsulated nano-EGCG and elemental Se nanoparticles dispersed by bovine serum albumin are reviewed in this article. Encapsulation of EGCG to form nano-EGCG leads to its enhanced stability in plasma and remarkably superior chemopreventive effects, with more than tenfold dose advantages in inducing apoptosis and inhibition of both angiogenesis and tumor growth. Se at nanoparticle size ("Nano-Se"), compared with Se compounds commonly used in dietary supplements, has significantly lower toxicity, without compromising its ability to upregulate selenoenzymes at nutritional levels and induce phase II enzymes at supranutritional levels.

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Green tea polyphenol (−)-epigallocatechin gallate reduces matrix metalloproteinase-9 activity following transient focal cerebral ischemia

Cited by 54 publications

References 41 publications

Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System

Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System

Catechin prevents severe dyslipidemia-associated changes in wall biomechanics of cerebral arteries in LDLr^−/−:hApoB^+/+ mice and improves cerebral blood flow

Encapsulated nanoepigallocatechin-3-gallate and elemental selenium nanoparticles as paradigms for nanochemoprevention

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Green tea polyphenol (−)-epigallocatechin gallate reduces matrix metalloproteinase-9 activity following transient focal cerebral ischemia

Cited by 54 publications

References 41 publications

Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System

Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System

Catechin prevents severe dyslipidemia-associated changes in wall biomechanics of cerebral arteries in LDLr−/−:hApoB+/+ mice and improves cerebral blood flow

Encapsulated nanoepigallocatechin-3-gallate and elemental selenium nanoparticles as paradigms for nanochemoprevention

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Catechin prevents severe dyslipidemia-associated changes in wall biomechanics of cerebral arteries in LDLr^−/−:hApoB^+/+ mice and improves cerebral blood flow