Green Tea Polyphenols: A Putative Mechanism for Cytotoxic Action against Cancer Cells

Farhan, Mohd; Shamim, Uzma; Hadi, S. M.

doi:10.1002/9781119436713.ch12

Cited by 7 publications

(1 citation statement)

References 154 publications

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“…Representative Flavonoids Food Sources References Flavanol Catechin, epicatechin, epigallocatechin-3-gallate Tea [27,28] Flavanone Naringin, naringenin, herperidin Citrus fruits, oranges, grapefruits, lemons [29] Anthocyanins Cyanidin, peonidin Blackberry, blueberry, cherry, strawberry [30] Flavones Chrysin, apigenin, luteolin Celery, green peppers, parsley, peppermint [31] Flavonols Kaempferol, quercetin, myricetin, rutin Blueberries, apple, cabbage, broccoli, cherries, garlic, onion, tea, red wine [32] Isoflavonoids Daidzein, genistein, glycitein Legumes, soy [33] Tannins (condensed form) Proanthocyanidins Cocoa beans, apples, red wine [34,35] Deoxyanthocyanidins Apigeninidin, luteolinidin Sorghum, purple corn [36] A number of studies have summarized the vast body of research on the bioavailability and absorption of flavonoids [37][38][39]. The molecular weight, glycosylation, and esterification of flavonoids, among other things, can impact their bioavailability, leading to some doubt about their actual levels of bioavailability as well as absorption in the human body [39].…”

Section: Classesmentioning

confidence: 99%

Current Understanding of Flavonoids in Cancer Therapy and Prevention

et al. 2023

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Cancer is a major cause of death worldwide, with multiple pathophysiological manifestations. In particular, genetic abnormalities, inflammation, bad eating habits, radiation exposure, work stress, and toxin consumption have been linked to cancer disease development and progression. Recently, natural bioactive chemicals known as polyphenols found in plants were shown to have anticancer capabilities, destroying altered or malignant cells without harming normal cells. Flavonoids have demonstrated antioxidant, antiviral, anticancer, and anti-inflammatory effects. Flavonoid type, bioavailability, and possible method of action determine these biological actions. These low-cost pharmaceutical components have significant biological activities and are beneficial for several chronic disorders, including cancer. Recent research has focused primarily on isolating, synthesizing, and studying the effects of flavonoids on human health. Here we have attempted to summarize our current knowledge of flavonoids, focusing on their mode of action to better understand their effects on cancer.

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