Green Tea Suppresses Brain Aging

Unno, Keiko; Nakamura, Yoriyuki

doi:10.3390/molecules26164897

Cited by 37 publications

(21 citation statements)

References 109 publications

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“…A variety of actions of EGCG have been described, particularly in the relation to cancer [ 116 , 117 , 118 , 119 , 120 , 121 , 122 ]; however, an improvement associated with delivery of EGCG has been also observed in many other disorders such as brain aging [ 123 , 124 ], neurological diseases including Parkinson’s and Alzheimer’s diseases [ 125 , 126 ], cardiovascular diseases [ 127 , 128 , 129 ], and metabolic diseases including obesity [ 130 , 131 ] and diabetes mellitus [ 132 , 133 ].…”

Section: Effects Of Egcg In Non-respiratory Diseasesmentioning

confidence: 99%

Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG): A Time for a New Player in the Treatment of Respiratory Diseases?

2022

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(-)-Epigallocatechin-3-gallate (EGCG) is a major polyphenol of green tea that possesses a wide variety of actions. EGCG acts as a strong antioxidant which effectively scavenges reactive oxygen species (ROS), inhibits pro-oxidant enzymes including NADPH oxidase, activates antioxidant systems including superoxide dismutase, catalase, or glutathione, and reduces abundant production of nitric oxide metabolites by inducible nitric oxide synthase. ECGC also exerts potent anti-inflammatory, anti-fibrotic, pro-apoptotic, anti-tumorous, and metabolic effects via modulation of a variety of intracellular signaling cascades. Based on this knowledge, the use of EGCG could be of benefit in respiratory diseases with acute or chronic inflammatory, oxidative, and fibrotizing processes in their pathogenesis. This article reviews current information on the biological effects of EGCG in those respiratory diseases or animal models in which EGCG has been administered, i.e., acute respiratory distress syndrome, respiratory infections, COVID-19, bronchial asthma, chronic obstructive pulmonary disease, lung fibrosis, silicosis, lung cancer, pulmonary hypertension, and lung embolism, and critically discusses effectiveness of EGCG administration in these respiratory disorders. For this review, articles in English language from the PubMed database were used.

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Section: Effects Of Egcg In Non-respiratory Diseasesmentioning

confidence: 99%

Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG): A Time for a New Player in the Treatment of Respiratory Diseases?

2022

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“…Much research has been conducted on the functionality of green tea components [ 29 , 30 , 31 , 32 ], and the importance of green tea as a form of preventive medicine has attracted attention. However, differences in the functionality of green tea can occur depending on the type and quality of the tea.…”

Section: Discussionmentioning

confidence: 99%

Improvement of Depressed Mood with Green Tea Intake

et al. 2022

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Being in a prolonged depressed state increases the risk of developing depression. To investigate whether green tea intake is effective in improving depression-like moods, we used an experimental animal model of depression with lipopolysaccharide (LPS) and clarified the effects of green tea on the biological stress response and inflammation in the brain. Regarding the stress reduction effect of green tea, we found that the sum of caffeine (C) and epigallocatechin gallate (E) relative to the sum of theanine (T) and arginine (A), the major components of green tea, or the CE/TA ratio, is important. The results showed that depression-like behavior, adrenal hypertrophy as a typical stress response, and brain inflammation were suppressed in mice fed green tea components with CE/TA ratios of 2 to 8. In addition, the expression of Npas4, which is reduced in anxiety and depression, was maintained at the same level as controls in mice that consumed green tea with a CE/TA ratio of 4. In clinical human trials, the consumption of green tea with CE/TA ratios of 3.9 and 4.7 reduced susceptibility to subjective depression. These results suggest that the daily consumption of green tea with a CE/TA ratio of 4–5 is beneficial to improving depressed mood.

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“…With the advent of an aging society, the prevention of aging, especially brain aging, is an important issue not only for improving the quality of life of individuals, but also for social and economic reasons. Using mouse models of aging, we found that the long-term intake of catechins, a green tea polyphenol, inhibits oxidative stress in vivo and suppresses brain atrophy and decline in learning and memory associated with aging [ 1 , 2 , 3 , 4 ]. In this study, we investigated the effects of coffee polyphenols (CPP or chlorogenic acid) and milk fat globule membrane (MFGM) in the prevention of brain aging in senescence-accelerated mouse prone 8, SAMP8, which shows cognitive decline and the accumulation of amyloid-β in the brain at a relatively early stage.…”

Section: Introductionmentioning

confidence: 99%

Coffee Polyphenol, Chlorogenic Acid, Suppresses Brain Aging and Its Effects Are Enhanced by Milk Fat Globule Membrane Components

Unno

Taguchi

Hase

et al. 2022

IJMS

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Mice feed with coffee polyphenols (CPP, chlorogenic acid) and milk fat globule membrane (MFGM) has increased survival rates and helps retain long-term memory. In the cerebral cortex of aged mice, CPP intake decreased the expression of the proinflammatory cytokine TNF-α, and lysosomal enzyme cathepsin B. The suppression of inflammation in the brain during aging was thought to result in the suppression of the repressor element 1-silencing transcription factor (REST) and prevention of brain aging. In contrast, CPP increased the expression of REST, cAMP-responsive element binding (CREB) and transforming growth factor β1 (TGF-β1) in the young hippocampus. The increased expression of these factors may contribute to the induction of neuronal differentiation and the suppression of memory decline with aging. Taken together, these results suggest that CPP increases CREB in the young hippocampus and suppresses inflammation in the old brain, resulting in a preventive effect on brain aging. The endotoxin levels were not elevated in the serum of aged mice. Although the mechanism of action of MFGM has not yet been elucidated, the increase in survival rate with both CPP and MFGM intake suggests that adding milk to coffee may improve not only the taste, but also the function.

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Green Tea Suppresses Brain Aging

Cited by 37 publications

References 109 publications

Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG): A Time for a New Player in the Treatment of Respiratory Diseases?

Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG): A Time for a New Player in the Treatment of Respiratory Diseases?

Improvement of Depressed Mood with Green Tea Intake

Coffee Polyphenol, Chlorogenic Acid, Suppresses Brain Aging and Its Effects Are Enhanced by Milk Fat Globule Membrane Components

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