We show that the coordinate ring of an open positroid variety coincides with the cluster algebra associated to a Postnikov diagram. This confirms conjectures of Postnikov, Muller-Speyer, and Leclerc, and generalizes results of Scott and Serhiyenko-Sherman-Bennett-Williams. • Π v,w ] with a basis of theta functions with positive structure constants. Additionally, the results of [LS16] imply that H * ( • Π v,w , C) satisfies the