Greener Approaches to Organic Synthesis Using Microreactor Technology

Abstract

He attended Franklin & Marshall College and received his B.A. in Chemistry in 2004. In the Fall of 2004, Andrew entered the graduate program in Chemistry and Chemical Biology at Cornell University and joined the research group of D. Tyler McQuade. His research currently involves the development of microreactors packed with solid-supported catalysts to be used in the continuous processing of small molecules and pharmaceutical agents. Kristin E. Price was born in Baltimore, MD, in 1979. She received her B.A. in Chemistry from Franklin & Marshall College in 2001. In August 2006, she completed her doctoral work under the guidance of Prof. D. Tyler McQuade at Cornell University.

Polymer precursors from catalytic reactions of natural oils

“…208 In the laboratory, micro-reactors are mostly employed and offer numerous advantages. [209][210][211][212][213][214] Safety is increased by using continuous flow reactions instead of batch reactions: thermal runaway is less likely, due to to the dominance of the thermal mass of the system. Moreover, continuous flow reactions allow the use of smaller reactors.…”

Novel synthesis of thick wall coatings of titania supported Bi poisoned Pd catalysts and application in selective hydrogenation of acetylene alcohols in capillary microreactors

“…27 This method was applied to obtain a 5-20 μm thick coating inside shorter (0.3 m) reactors 28 or a thin coating (90 nm) inside 10-m long reactors. 23,29 Another derivative of the dip-coating method, the fill-and-dry method, can be used to obtain [10][11][12][13][14][15][16][17][18][19][20] μm thick catalytic coatings inside short reactors. [30][31][32] However, the essential component of these methods, solvent evaporation, requires years to remove solvent from a longer (5 m) reactor according to estimations performed using Stefan's equation, 33 Fig.…”

Triethylamine and TBD supported on silica: useful heterogeneous catalysts for the reaction of β-dicarbonyl derivatives with α,β-unsaturated compounds under batch and continuous flow conditions

“…This strategy offers significant improvements compared to conventional batch processes due to a precise control of residence time, heat and mass transport, and is thus a route to minimize wastes and develop more efficient and sustainable syntheses. 25 In a preliminary batch experiment, the model reaction of butenone (1a -10 mmol) and pentane-2,4-dione (2a -10 mmol) in toluene (10 mL) with 0.9 g of KG-NEt 2 (10% mol -loading: 1.1 mmol/g) has been carried out at room temperature. Upon 5 hours, the mono-alkylated Michael product 3aa was isolated in a poor yield (9%) with high selectivity (100%).…”