Greener Approaches to Organic Synthesis Using Microreactor Technology

Mason, Brian P.; Price, Kristin E.; Steinbacher, Jeremy L.; Bogdan, Andrew R.; McQuade, D. Tyler

doi:10.1002/chin.200736259

Cited by 81 publications

(90 citation statements)

References 1 publication

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“…[123] Other approaches to improve the durability of platinum-based catalysts and to further optimize the hydrosilylation process is the use of ionic liquids ILs as well as microreactors. Microreactors enable the performance of continuous chemical reaction process in tubes with small diameter, which results in higher yields due to a high surface:volume ratio and therefore increased mass transfer [124]. Studies performed by Kukawa et al indicate higher yields (98%) for the hydrosilylation of 1,1,1,3,5,5,5-heptatrimethylsiloxane with oct-1-ene in ILs when using a continuous flow reactor ( Figure 43).…”

Section: High Efficient/low-cost Hydrosilylation (Solvent-free Conditmentioning

confidence: 99%

Fifty Years of Hydrosilylation in Polymer Science: A Review of Current Trends of Low-Cost Transition-Metal and Metal-Free Catalysts, Non-Thermally Triggered Hydrosilylation Reactions, and Industrial Applications

2017

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Hydrosilylation reactions, the (commonly) anti-Markovnikov additions of silanes to unsaturated bonds present in compounds such as alkenes and alkynes, offer numerous unique and advantageous properties for the preparation of polymeric materials, such as high yields and stereoselectivity. These reactions require to be catalyzed, for which platinum compounds were used in the initial stages. Celebrating the 50th anniversary of hydrosilylations in polymer science and, concomitantly, five decades of continuously growing research, hydrosilylation reactions have advanced to a level that renders them predestined for transfer into commercial products on the large scale. Facing this potential transfer, this review addresses and discusses selected current trends of the scientific research in the area, namely low-cost transition metal catalysts (focusing on iron, cobalt, and nickel complexes), metal-free catalysts, non-thermally triggered hydrosilylation reactions (highlighting stimuli such as (UV-)light), and (potential) industrial applications (highlighting the catalysts used and products manufactured). This review focuses on the hydrosilylation reactions involving alkene reactants.

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Section: High Efficient/low-cost Hydrosilylation (Solvent-free Conditmentioning

confidence: 99%

Fifty Years of Hydrosilylation in Polymer Science: A Review of Current Trends of Low-Cost Transition-Metal and Metal-Free Catalysts, Non-Thermally Triggered Hydrosilylation Reactions, and Industrial Applications

2017

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“…It also offers better regioselectivity, chemical selectivity, and yield for many chemical reactions with minimal byproducts [2][3][4][5][6][7]. With the development of better droplet control models, microreactors have attracted much attention from the fundamental and applied scientists in biology and chemistry [8,9]. *Corresponding author (email: xdwu@nimte.ac.cn)…”

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confidence: 99%

Profile characterization and temperature dependence of droplet control on textured surfaces

Feng

Xue

2011

Chin. Sci. Bull.

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Droplet control on textured surfaces has attracted much attention in the fields of drag reduction and high-efficiency microreactors. We investigated the profile characterization and temperature dependence of droplet control between wetting and non-wetting on a series of textured silicon surfaces. Surfaces were fabricated using photolithography, and the temperature-dependent wettability of the single phase regime droplets was characterized using dynamic contact angle measurements. The experiments demonstrated that the profile of textured surfaces characterizes the droplets Leidenfrost point. The Leidenfrost point is proportional to the micro-pillar size and rectangular wave-length of the textured surface and is inversely proportional to ambient temperature. The Leidenfrost droplets moved freely on the textured surface, almost without hysteresis. Droplets could be directed on the surface of microreactors with a low driving force. textured surface, Leidenfrost droplet, droplet control, drag reduction, microreactors Citation:Feng R T, Wu X D, Xue Q J. Profile characterization and temperature dependence of droplet control on textured surfaces.

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“…Microreactors are very attractive devices for many different applications [6,7,8,9]. Different from the traditional scaleup, micro/milli channel reactors reach bulk chemicals productions via so called numbering up, placing multiple channels in parallel [10,11,12,13].…”

Section: Introductionmentioning

confidence: 99%

Numbered-up gas–liquid micro/milli channels reactor with modular flow distributor

Al-Rawashdeh

Nijhuis

et al. 2012

Chemical Engineering Journal

108

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Gas-liquid processing in microreactors remains mostly restricted to the laboratory scale due to the complexity and expenditure needed for an adequate numbering-up with a uniform flow distribution. Here, the numbering-up is presented for multiphase (gas-liquid) flow in microreactor suitable for a production capacity of kg/h. Based on the barrier channels concept, the barrier-based micro/milli reactor (BMMR) is designed and fabricated to deliver flow non-uniformity of less than 10%. The BMMR consists of eight parallel channels all operated in the Taylor flow regime and with a liquid flow rate up to 150 mL/min. The quality of the flow distribution is reported by studying two aspects. The first aspect is the influence of different viscosities, surface tensions and flow rates. The second aspect is the influence of modularity by testing three different reaction channels type: (1) square channels fabricated in a stainless steel plate, (2) in a glass plate, and (3) circular channels (capillaries) made of stainless steel.Additionally, the BMMR is compared to that of a single channel regard the slug and bubble lengths and bubble generation frequency. The results pave the ground for bringing multiphase flow in microreactor one step closer for large scale production via numbering-up.

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Greener Approaches to Organic Synthesis Using Microreactor Technology

Abstract: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Cited by 81 publications

References 1 publication

Fifty Years of Hydrosilylation in Polymer Science: A Review of Current Trends of Low-Cost Transition-Metal and Metal-Free Catalysts, Non-Thermally Triggered Hydrosilylation Reactions, and Industrial Applications

Fifty Years of Hydrosilylation in Polymer Science: A Review of Current Trends of Low-Cost Transition-Metal and Metal-Free Catalysts, Non-Thermally Triggered Hydrosilylation Reactions, and Industrial Applications

Profile characterization and temperature dependence of droplet control on textured surfaces

Numbered-up gas–liquid micro/milli channels reactor with modular flow distributor

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