Greener derivatization in analytical chemistry

Lavilla, Isela; Romero, Vanesa; Costas, Isabel; Bendicho, Carlos

doi:10.1016/j.trac.2014.05.007

Cited by 64 publications

(24 citation statements)

References 76 publications

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“…Derivatization is critical to enhance the sensitivity and/or selectivity of methods in GC–MS analysis (Lavilla, Romero, Costas, & Bendicho, ). Many studies have reported developing and improving methods of derivatization by reducing product waste, using safer solvents and increasing energy efficiency (Al‐Okab & Syed, ; Dasgupta, Banerjee, & Malik, ; Fabbri, Baravelli, Chiavari, & Prati, ; Naik, Bhattacharjya, Talukdar, & Patel, ).…”

Section: Resultsmentioning

confidence: 99%

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GC–MS analysis of organic acids in rat urine: A protocol of direct ultrasound‐assisted derivatization

Liu

Guo

et al. 2020

Biomedical Chromatography

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The aim of the present study was to develop a novel ultrasound‐assisted derivatization method for analysis of urine that can be used for preliminary screening and monitoring of metabolic disorders. Here we describe an ultrasound‐assisted derivatization method followed by GC–MS analysis to quantify 26 organic acids in urine. The optimum levels of the variables affecting the yield of derivatization were investigated, including urease doses, derivatization reagents and derivatization conditions (duration time, reaction temperature and sonic power). The method exhibited the best results with 80 μl urease. The optimal reaction conditions were 100 μl BSTFA, 80% ultrasound power, 70°C and 40 min. This method showed satisfactory linearity, good reproducibility and an acceptable limit of detection and accuracy. Therefore, it could potentially be used to as a standard method to enable comparisons between laboratories. Finally, we applied our method to urine samples from pregnant rats administered 2 or 10 mg/kg folic acid supplementation.

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Section: Resultsmentioning

confidence: 99%

“…Derivatization is critical to enhance the sensitivity and/or selectivity of methods in GC-MS analysis (Lavilla, Romero, Costas, & Bendicho, 2014 (Prata et al, 2012). However, as mentioned by Luque de Castro, US is typically applied at a fixed frequency.…”

Section: Optimization Of Sample Derivatizationmentioning

confidence: 99%

GC–MS analysis of organic acids in rat urine: A protocol of direct ultrasound‐assisted derivatization

Liu

Guo

et al. 2020

Biomedical Chromatography

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“…As MAD decreases the reaction time avoiding prolong use of classical heating, it is considered as one of the approaches to greener derivatization in analytical laboratories. 44 Therefore, our method of MAD for the quantification of FA is an environmental-friendly derivatization process.…”

Section: Comparison With Conventional Methodsmentioning

confidence: 99%

Microwave-assisted Derivatization of Fatty Acids for Its Measurement in Milk Using High-Performance Liquid Chromatography

et al. 2018

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Fatty acid (FA) profiling of milk has important applications in human health and nutrition. Conventional methods for the saponification and derivatization of FA are time-consuming and laborious. We aimed to develop a simple, rapid, and economical method for the determination of FA in milk. We applied a beneficial approach of microwave-assisted saponification (MAS) of milk fats and microwave-assisted derivatization (MAD) of FA to its hydrazides, integrated with HPLC-based analysis. The optimal conditions for MAS and MAD were determined. Microwave irradiation significantly reduced the sample preparation time from 80 min in the conventional method to less than 3 min. We used three internal standards for the measurement of short-, medium- and long-chain FA. The proposed method showed satisfactory analytical sensitivity, recovery and reproducibility. There was a significant correlation in the milk FA concentrations between the proposed and conventional methods. Being quick, economic, and convenient, the proposed method for the milk FA measurement can be substitute for the convention method.

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“…Ionic liquids (ILs) contain organic cations and inorganic anions with unique properties, such as low melting temperature, high thermal stability, wide liquid phase range, non-ammability and low vapor pressure, but imidazoliumbased ILs entail high cost and exhibit toxicity. [12][13][14] Therefore, the use of green and economic solvents instead of hazardous solvents is one of the most important considerations in green technology. [15][16][17] In 2011, Robert Verpoorte and his co-workers 18 postulated a new type of solvents, called natural deep eutectic solvents (NADESs), which are composed of the primary metabolites of living cells.…”

Section: Introductionmentioning

confidence: 99%

Natural deep eutectic solvents as new green solvents to extract anthraquinones from Rheum palmatum L.

et al. 2018

RSC Adv.

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Greener derivatization in analytical chemistry

Cited by 64 publications

References 76 publications

GC–MS analysis of organic acids in rat urine: A protocol of direct ultrasound‐assisted derivatization

GC–MS analysis of organic acids in rat urine: A protocol of direct ultrasound‐assisted derivatization

Microwave-assisted Derivatization of Fatty Acids for Its Measurement in Milk Using High-Performance Liquid Chromatography

Natural deep eutectic solvents as new green solvents to extract anthraquinones from Rheum palmatum L.

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