Greener Synthesis of an Amide by Direct Reaction of an Acid and Amine under Catalytic Conditions

Arce, Gabriel; Carrau, Gonzalo; Bellomo, Ana; González, David

doi:10.12691/wjce-3-1-4

Cited by 18 publications

(5 citation statements)

References 12 publications

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“…This trend can be explained by the amidation reaction between these groups catalyzed by H 3 BO 3 . [ 32 ] As seen, the PEI@PAAc spectrum exhibited new bands at 1652 and 1627 cm −1 attributable to the amide I band of tertiary and secondary amide groups. [ 33 ] The new band at 1508 cm −1 is related to the amide II band of secondary amides.…”

Section: Resultsmentioning

confidence: 95%

Copper supported on polyethyleneimine‐coated microparticles for the efficient synthesis of organoselenium compounds

Souza

Aquino

Nunes

et al. 2022

Applied Organom Chemis

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Copper‐catalyzed reactions are in continuous evidence due to their attractive features, and the use of solid materials to support this metal has broadened the possibilities in terms of application. To demonstrate this, polyacrylic acid (PAAc) microparticles coated with polyethyleneimine (PEI) were synthesized and utilized to support Cu2+ ions. These hybrid microparticles were tested as heterogeneous catalysts in the synthesis of 3‐arylselanylindoles. Overall, products were synthesized in good to moderate yields using 10 mg of the catalyst containing a meager amount of Cu2+ (2 μmol). Also, the heterogeneous reaction mediated by PEI@PAAc/Cu2+ microparticles was more efficient than the homogeneous catalysis. Reuse experiments demonstrated that PEI@PAAc/Cu2+ microparticles show appreciable catalytic performance up to three consecutive runs under the tested experimental conditions. Overall, the PEI@PAAc/Cu2+ microparticles serve as a support material for Cu2+ and can be exploited as heterogeneous catalysts for the synthesis of organoselenium compounds.

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Section: Resultsmentioning

confidence: 95%

Copper supported on polyethyleneimine‐coated microparticles for the efficient synthesis of organoselenium compounds

Souza

Aquino

Nunes

et al. 2022

Applied Organom Chemis

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“…This particular reaction, which goes with direct amidation (see GlyHT mechanism), has been widely reported in several papers and one patent. [18][19][20][21] Correspondingly, boron is not expected to be incorporated in the organic structure as a dopant. Our recent work [9] on the polymerization of an analogous amino acid, L-lysine, confirms the catalytic effect of boric acid.…”

Section: Resultsmentioning

confidence: 99%

The Birth of Fluorescence from Thermally Polymerized Glycine

Cossu

Poddighe

Stagi

et al. 2022

Macro Chemistry & Physics

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Thermal polymerization of glycine, the simplest amino acid bearing only one alfa carbon atom, is not an efficient process in mild conditions. Hydrothermal processing of glycine produces only small peptides, up to four units on average, with only a fraction of glycine that reacts. In the present work, boric acid is used as a catalyst to promote the formation of glycine polypeptides. The final product is characterized by an extended polymeric structure and an intense blue fluorescence characterizes the final product. A comparison with glycine reacted in hydrothermal conditions without the catalyst shows that boric acid plays a primary role in promoting the amidation reactions. The structure of the glycine polymers has been investigated by nuclear magnetic resonance, Fourier transform infrared and Raman spectroscopies, and the optical properties by UV-vis and fluorescence spectroscopies. The full reaction of glycine promoted by boric acid catalysis produces a disordered structure with loss of molecular conformations and blue emission.

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“…The mixed anhydride is an activated form of the acid and it is the actual reacting species [19]. In contrast to conventional methods, the mixed anhydride is in situ formed and only catalytic amount is present at any time during the course of reaction.As the reaction temperature is 160-180°C.…”

Section: Resultsmentioning

confidence: 99%

Solvent-Free Synthesis of Amide: A Novel Technique of Green Chemistry

Gohil¹,

Noolvi²

2021

Asian J Pharm Clin Res

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Objective: Amide is one of the most important functional group presents in the chemicals, pharmaceuticals, and foods. Conventionally, it has been synthesized from the carboxylic acid and amines. This conventional reaction is lengthy and involves hazardous chemicals and solvents. Hence, it poses waste management, solvent removal, and environmental issues to the industries. To overcome this limitation, we have reported the green chemistry-based method for the synthesis of amide from carboxylic acid and urea. Methods: In this reaction, we have used boric acid as a catalyst, it is a simple and readily available compound. It is simple, efficient, and solvent-free procedure which involves the trituration of the reactant mixture and subsequent, direct heating of the triturated mixture. Results: The rate of reaction is very high and can synthesize the amide quickly. Conclusion: Various amides were prepared in good yield by this technique.

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Greener Synthesis of an Amide by Direct Reaction of an Acid and Amine under Catalytic Conditions

Cited by 18 publications

References 12 publications

Copper supported on polyethyleneimine‐coated microparticles for the efficient synthesis of organoselenium compounds

Copper supported on polyethyleneimine‐coated microparticles for the efficient synthesis of organoselenium compounds

The Birth of Fluorescence from Thermally Polymerized Glycine

Solvent-Free Synthesis of Amide: A Novel Technique of Green Chemistry

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